Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292693910> ?p ?o ?g. }
- W4292693910 abstract "Summary The piRNA pathway in mosquitoes differs substantially from other model organisms, with an expanded PIWI gene family and functions in antiviral defense. Here, we defined core piRNA clusters as small RNA source loci that showed ubiquitous expression in both somatic and germline tissues. These core piRNA clusters were enriched for non-retroviral endogenous viral elements (nrEVEs) in antisense orientation and depended on key biogenesis factors, Nxf1, Veneno, Tejas, Yb, and Shutdown. Combined transcriptome and chromatin state analyses identified transcriptional readthrough as a conserved mechanism for piRNA cluster biogenesis in Aedes aegypti , Aedes albopictus , Culex quinquefasciatus , and Anopheles gambiae . Comparative analyses between two Aedes mosquitoes suggested that piRNA clusters function as traps for nrEVEs, allowing adaptation to environmental challenges such as virus infection. Our systematic transcriptome and chromatin state analyses lay the foundation for studies of gene regulation, genome evolution and piRNA functions in these important vector species. Graphical abstract Highlights Core piRNA clusters showed ubiquitous expression in both somatic and germline tissues in four vector mosquitoes. Chromatin profiling identifies transcriptional readthrough as a conserved mechanism for piRNA biogenesis. Biogenesis of cluster-derived piRNAs depends on key factors, Nxf1, Veneno, Tejas, Yb, and Shutdown. piRNA clusters function as traps for viral elements downstream of conserved set of genes in Aedes mosquitoes" @default.
- W4292693910 created "2022-08-23" @default.
- W4292693910 creator A5024666474 @default.
- W4292693910 creator A5029608447 @default.
- W4292693910 creator A5040007262 @default.
- W4292693910 creator A5060690628 @default.
- W4292693910 creator A5070781854 @default.
- W4292693910 date "2022-08-22" @default.
- W4292693910 modified "2023-10-06" @default.
- W4292693910 title "Chromatin profiling identifies transcriptional readthrough as a conserved mechanism for piRNA cluster biogenesis in mosquitoes" @default.
- W4292693910 cites W1481145197 @default.
- W4292693910 cites W1908905777 @default.
- W4292693910 cites W1968817160 @default.
- W4292693910 cites W1971393011 @default.
- W4292693910 cites W1972649540 @default.
- W4292693910 cites W1976342457 @default.
- W4292693910 cites W1991007428 @default.
- W4292693910 cites W1991543373 @default.
- W4292693910 cites W1996321460 @default.
- W4292693910 cites W2009644747 @default.
- W4292693910 cites W2010970638 @default.
- W4292693910 cites W2013883400 @default.
- W4292693910 cites W2015231728 @default.
- W4292693910 cites W2018765039 @default.
- W4292693910 cites W2021618307 @default.
- W4292693910 cites W2023092952 @default.
- W4292693910 cites W2029946299 @default.
- W4292693910 cites W2044043271 @default.
- W4292693910 cites W2045845081 @default.
- W4292693910 cites W2062288798 @default.
- W4292693910 cites W2064444082 @default.
- W4292693910 cites W2072855119 @default.
- W4292693910 cites W2075956161 @default.
- W4292693910 cites W2076154138 @default.
- W4292693910 cites W2077157705 @default.
- W4292693910 cites W2078105351 @default.
- W4292693910 cites W2078525643 @default.
- W4292693910 cites W2081322742 @default.
- W4292693910 cites W2087739002 @default.
- W4292693910 cites W2087785865 @default.
- W4292693910 cites W2101708445 @default.
- W4292693910 cites W2102619694 @default.
- W4292693910 cites W2103441770 @default.
- W4292693910 cites W2105202278 @default.
- W4292693910 cites W2107277218 @default.
- W4292693910 cites W2108108770 @default.
- W4292693910 cites W2108234281 @default.
- W4292693910 cites W2110161291 @default.
- W4292693910 cites W2110764940 @default.
- W4292693910 cites W2113377893 @default.
- W4292693910 cites W2115829042 @default.
- W4292693910 cites W2117757143 @default.
- W4292693910 cites W2117792884 @default.
- W4292693910 cites W2118937292 @default.
- W4292693910 cites W2121053876 @default.
- W4292693910 cites W2121743800 @default.
- W4292693910 cites W2126417923 @default.
- W4292693910 cites W2130036534 @default.
- W4292693910 cites W2134487562 @default.
- W4292693910 cites W2143634826 @default.
- W4292693910 cites W2149562859 @default.
- W4292693910 cites W2150781353 @default.
- W4292693910 cites W2154883726 @default.
- W4292693910 cites W2156597566 @default.
- W4292693910 cites W2158266834 @default.
- W4292693910 cites W2158789637 @default.
- W4292693910 cites W2161222316 @default.
- W4292693910 cites W2162325860 @default.
- W4292693910 cites W2162906125 @default.
- W4292693910 cites W2164206207 @default.
- W4292693910 cites W2166820820 @default.
- W4292693910 cites W2169456326 @default.
- W4292693910 cites W2178554527 @default.
- W4292693910 cites W2281309807 @default.
- W4292693910 cites W2411724331 @default.
- W4292693910 cites W2571283472 @default.
- W4292693910 cites W2580312397 @default.
- W4292693910 cites W2589313270 @default.
- W4292693910 cites W2612265006 @default.
- W4292693910 cites W2748864067 @default.
- W4292693910 cites W2748881498 @default.
- W4292693910 cites W2767360610 @default.
- W4292693910 cites W2768013244 @default.
- W4292693910 cites W2773195131 @default.
- W4292693910 cites W2800362454 @default.
- W4292693910 cites W2807631303 @default.
- W4292693910 cites W2896675470 @default.
- W4292693910 cites W2898440040 @default.
- W4292693910 cites W2901102079 @default.
- W4292693910 cites W2920001103 @default.
- W4292693910 cites W2920831358 @default.
- W4292693910 cites W2921763102 @default.
- W4292693910 cites W2929351296 @default.
- W4292693910 cites W2949448083 @default.
- W4292693910 cites W2949907289 @default.
- W4292693910 cites W2951987731 @default.
- W4292693910 cites W2952674322 @default.
- W4292693910 cites W2967128888 @default.
- W4292693910 cites W2968255719 @default.
- W4292693910 cites W2980465488 @default.