Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292714092> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4292714092 endingPage "155" @default.
- W4292714092 startingPage "146" @default.
- W4292714092 abstract "Background: Schistosomiasis is one of the neglected tropical parasitic diseases of socioeconomic and public health importance and there is need to search for a potent anti-schistosomal drugs from among our rich medicinal plant population. Objective: The objective of the study was to determine the in vivo anti-schistosomal activity of Azadirachta indica methanolic extract seed kernel in experimentally infected Wister rats. Methodology: Forty (40) Albino rats were randomized into eight (8) groups each of five rats to include the treatment and control groups. Thirty-five (35) Rats were infected each with 150 cercariae and treated orally with varying doses of Azadirachta indica methanolic extract seed kernel at doses 400mg/kg, 600mg/kg, 800mg/kg and 1000mg/kg bodyweight of the animals at eight weeks post-infection. Praziquantel was used as positive control and infected untreated group was used as negative control. Mean worm recovery as well as percentage reduction were used as an indicator of drug activity relative to the infected untreated control group.Results: The extracts showed significant dose dependent percentage worm reduction and mean worm recovery count at various doses ranging from 21±0.80 to 5.60±0.76 and percentage worm reduction ranging from 78.3% to 94.2%. Anti-schistosomal activity of methanol extract of Azadirachta indica seed kernel was confirmed to be dose dependent. The evidence of anti-schistosomal activity of the extract was supported by reduced pathological changes (induced by the infection). Conclusion: Our research showed that methanolic extract of neem seed kernel has anti-schistosomal activity and is effective in reducing worm burden in rats after schistosomiasis infection. The plant may be considered if standardized to fight the Schistosome infection in humans" @default.
- W4292714092 created "2022-08-23" @default.
- W4292714092 creator A5044356289 @default.
- W4292714092 creator A5048542697 @default.
- W4292714092 creator A5068099146 @default.
- W4292714092 creator A5082922196 @default.
- W4292714092 date "2021-08-01" @default.
- W4292714092 modified "2023-10-06" @default.
- W4292714092 title "Invivo Anti-schistosomal Activity Of Methanolic Extract From Azadirachta Indica (neem) Seed Kernel In Experimentally Infected Wister Rats" @default.
- W4292714092 doi "https://doi.org/10.56167/jjms.2021.0202.18" @default.
- W4292714092 hasPublicationYear "2021" @default.
- W4292714092 type Work @default.
- W4292714092 citedByCount "0" @default.
- W4292714092 crossrefType "journal-article" @default.
- W4292714092 hasAuthorship W4292714092A5044356289 @default.
- W4292714092 hasAuthorship W4292714092A5048542697 @default.
- W4292714092 hasAuthorship W4292714092A5068099146 @default.
- W4292714092 hasAuthorship W4292714092A5082922196 @default.
- W4292714092 hasConcept C165901193 @default.
- W4292714092 hasConcept C203014093 @default.
- W4292714092 hasConcept C2776225656 @default.
- W4292714092 hasConcept C2779744950 @default.
- W4292714092 hasConcept C2781035296 @default.
- W4292714092 hasConcept C2781131524 @default.
- W4292714092 hasConcept C33070731 @default.
- W4292714092 hasConcept C42972112 @default.
- W4292714092 hasConcept C556039675 @default.
- W4292714092 hasConcept C71924100 @default.
- W4292714092 hasConcept C86803240 @default.
- W4292714092 hasConceptScore W4292714092C165901193 @default.
- W4292714092 hasConceptScore W4292714092C203014093 @default.
- W4292714092 hasConceptScore W4292714092C2776225656 @default.
- W4292714092 hasConceptScore W4292714092C2779744950 @default.
- W4292714092 hasConceptScore W4292714092C2781035296 @default.
- W4292714092 hasConceptScore W4292714092C2781131524 @default.
- W4292714092 hasConceptScore W4292714092C33070731 @default.
- W4292714092 hasConceptScore W4292714092C42972112 @default.
- W4292714092 hasConceptScore W4292714092C556039675 @default.
- W4292714092 hasConceptScore W4292714092C71924100 @default.
- W4292714092 hasConceptScore W4292714092C86803240 @default.
- W4292714092 hasIssue "2" @default.
- W4292714092 hasLocation W42927140921 @default.
- W4292714092 hasOpenAccess W4292714092 @default.
- W4292714092 hasPrimaryLocation W42927140921 @default.
- W4292714092 hasRelatedWork W2023450084 @default.
- W4292714092 hasRelatedWork W2109893892 @default.
- W4292714092 hasRelatedWork W2185717325 @default.
- W4292714092 hasRelatedWork W2413881963 @default.
- W4292714092 hasRelatedWork W284550690 @default.
- W4292714092 hasRelatedWork W3010070825 @default.
- W4292714092 hasRelatedWork W4292714092 @default.
- W4292714092 hasRelatedWork W4304099622 @default.
- W4292714092 hasRelatedWork W4318621692 @default.
- W4292714092 hasRelatedWork W4323295572 @default.
- W4292714092 hasVolume "2" @default.
- W4292714092 isParatext "false" @default.
- W4292714092 isRetracted "false" @default.
- W4292714092 workType "article" @default.