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- W4292755652 endingPage "111251" @default.
- W4292755652 startingPage "111251" @default.
- W4292755652 abstract "Membraneless biomolecular condensates (BMCs) contribute to the replication of a growing number of viruses but remain to be functionally characterized. Previously, we demonstrated that pan-retroviral nucleocapsid (NC) proteins phase separated into condensates regulating virus assembly. Here we discover that intrinsically disordered human immunodeficiency virus-type 1 (HIV-1) core proteins condense with the viral genomic RNA (vRNA) to assemble as BMCs attaining a geometry characteristic of viral reverse transcription complexes. We explore the predisposition, mechanisms, and pharmacologic sensitivity of HIV-1 core BMCs in living cells. HIV-1 vRNA-interacting NC condensates were found to be scaffolds onto which client capsid, reverse transcriptase, and integrase condensates assemble. HIV-1 core BMCs exhibit fundamental characteristics of BMCs and are drug-sensitive. Lastly, protease-mediated maturation of Gag and Gag-Pol precursor proteins yield abundant and visible BMCs in cells. This study redefines HIV-1 core components as fluid BMCs and advances our understanding of the nature of viral cores during ingress." @default.
- W4292755652 created "2022-08-23" @default.
- W4292755652 creator A5001515707 @default.
- W4292755652 creator A5011414484 @default.
- W4292755652 creator A5017336227 @default.
- W4292755652 creator A5030529590 @default.
- W4292755652 creator A5086850461 @default.
- W4292755652 date "2022-08-01" @default.
- W4292755652 modified "2023-10-18" @default.
- W4292755652 title "Scaffolding viral protein NC nucleates phase separation of the HIV-1 biomolecular condensate" @default.
- W4292755652 cites W1495541129 @default.
- W4292755652 cites W1601304840 @default.
- W4292755652 cites W1630981685 @default.
- W4292755652 cites W1641947900 @default.
- W4292755652 cites W1792685479 @default.
- W4292755652 cites W1823429634 @default.
- W4292755652 cites W1895300367 @default.
- W4292755652 cites W1952608303 @default.
- W4292755652 cites W1973261539 @default.
- W4292755652 cites W1977218442 @default.
- W4292755652 cites W1986015062 @default.
- W4292755652 cites W1993771057 @default.
- W4292755652 cites W2006176165 @default.
- W4292755652 cites W2008188453 @default.
- W4292755652 cites W2014776147 @default.
- W4292755652 cites W2020675689 @default.
- W4292755652 cites W2027525387 @default.
- W4292755652 cites W2031620294 @default.
- W4292755652 cites W2033265046 @default.
- W4292755652 cites W2036545702 @default.
- W4292755652 cites W2036952474 @default.
- W4292755652 cites W2038103688 @default.
- W4292755652 cites W2043610505 @default.
- W4292755652 cites W2047791613 @default.
- W4292755652 cites W2048222477 @default.
- W4292755652 cites W2049476357 @default.
- W4292755652 cites W2049853774 @default.
- W4292755652 cites W2053940497 @default.
- W4292755652 cites W2056343782 @default.
- W4292755652 cites W2062656304 @default.
- W4292755652 cites W2065844510 @default.
- W4292755652 cites W2070126374 @default.
- W4292755652 cites W2073273867 @default.
- W4292755652 cites W2078893156 @default.
- W4292755652 cites W2083825092 @default.
- W4292755652 cites W2085978470 @default.
- W4292755652 cites W2086253922 @default.
- W4292755652 cites W2089929673 @default.
- W4292755652 cites W2090070116 @default.
- W4292755652 cites W2091009518 @default.
- W4292755652 cites W2091216865 @default.
- W4292755652 cites W2096839398 @default.
- W4292755652 cites W2099277378 @default.
- W4292755652 cites W2102089867 @default.
- W4292755652 cites W2104422107 @default.
- W4292755652 cites W2105140840 @default.
- W4292755652 cites W2106635550 @default.
- W4292755652 cites W2109223952 @default.
- W4292755652 cites W2116193414 @default.
- W4292755652 cites W2120792521 @default.
- W4292755652 cites W2123942995 @default.
- W4292755652 cites W2139995722 @default.
- W4292755652 cites W2143340858 @default.
- W4292755652 cites W2150860983 @default.
- W4292755652 cites W2156829363 @default.
- W4292755652 cites W2165284441 @default.
- W4292755652 cites W2169196764 @default.
- W4292755652 cites W2172125721 @default.
- W4292755652 cites W2220328959 @default.
- W4292755652 cites W2258168758 @default.
- W4292755652 cites W2293962087 @default.
- W4292755652 cites W2414034576 @default.
- W4292755652 cites W2513660300 @default.
- W4292755652 cites W2552952185 @default.
- W4292755652 cites W2605353593 @default.
- W4292755652 cites W2731724500 @default.
- W4292755652 cites W2743471889 @default.
- W4292755652 cites W2744923425 @default.
- W4292755652 cites W2780927228 @default.
- W4292755652 cites W2807065786 @default.
- W4292755652 cites W2854081253 @default.
- W4292755652 cites W2891317436 @default.
- W4292755652 cites W2905905427 @default.
- W4292755652 cites W2914907359 @default.
- W4292755652 cites W2952564407 @default.
- W4292755652 cites W2957306231 @default.
- W4292755652 cites W2969279439 @default.
- W4292755652 cites W2981857742 @default.
- W4292755652 cites W2990722035 @default.
- W4292755652 cites W3012276372 @default.
- W4292755652 cites W3013114619 @default.
- W4292755652 cites W3016901182 @default.
- W4292755652 cites W3031487353 @default.
- W4292755652 cites W3035370963 @default.
- W4292755652 cites W3035864988 @default.
- W4292755652 cites W3038184119 @default.
- W4292755652 cites W3044717219 @default.
- W4292755652 cites W3049249652 @default.