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- W4292755723 endingPage "111238" @default.
- W4292755723 startingPage "111238" @default.
- W4292755723 abstract "Recapitulation of embryonic pancreatic development has enabled development of methods for in vitro islet cell differentiation using human pluripotent stem cells (hPSCs), which have the potential to cure diabetes. Advanced methods for optimal generation of stem-cell-derived islets (SC-islets) has enabled successful diabetes reversal in rodents and shown promising early clinical trial outcomes. The main impediment for use of SC-islets is concern about safety because of off-target growth resulting from contaminated residual cells. In this review, we summarize the different endocrine and non-endocrine cell populations that have been described to emerge throughout β cell differentiation and after transplantation. We discuss the most recent approaches to enrich endocrine populations and remove off-target cells. Finally, we discuss the critical quality control and release criteria testing that we anticipate will be required prior to transplantation to ensure product safety." @default.
- W4292755723 created "2022-08-23" @default.
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- W4292755723 date "2022-08-01" @default.
- W4292755723 modified "2023-10-16" @default.
- W4292755723 title "Characterization of stem-cell-derived islets during differentiation and after implantation" @default.
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- W4292755723 doi "https://doi.org/10.1016/j.celrep.2022.111238" @default.
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