Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292767317> ?p ?o ?g. }
- W4292767317 abstract "Abstract An early symptom of Alzheimer’s disease (AD) is an impaired sense of smell, for which the molecular basis remains elusive. Here, we generated human olfactory neurosphere-derived (ONS) cells from people with AD and mild cognitive impairment (MCI), and performed global RNA sequencing to determine gene expression changes. ONS cells expressed markers of neuroglial differentiation, providing a unique cellular model to explore early AD-associated disease pathways. Our transcriptomics data from ONS cells revealed differentially expressed genes (DEGs) associated with cognitive processes in AD cells compared to MCI, or matched healthy controls (HC). A-Kinase Anchoring Protein 6 ( AKAP6) was the most significantly altered gene in AD compared to both MCI and HC, and has been linked to cognitive function. The greatest change in gene expression of all DEGs occurred between AD and MCI. Gene pathway analysis revealed defects in multiple cellular processes with aging, intellectual deficiency and alternative splicing being the most significantly dysregulated in AD ONS cells. Our results demonstrate that ONS cells can provide a cellular model for AD that recapitulates disease-associated differences. We have revealed potential novel genes, including AKAP6 that may have a role in AD, particularly MCI to AD transition, and should be further examined." @default.
- W4292767317 created "2022-08-23" @default.
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- W4292767317 date "2022-08-23" @default.
- W4292767317 modified "2023-10-15" @default.
- W4292767317 title "An Alzheimer’s disease patient-derived olfactory cell model identifies gene expression changes associated with cognition" @default.
- W4292767317 cites W139959913 @default.
- W4292767317 cites W1566781674 @default.
- W4292767317 cites W1838176546 @default.
- W4292767317 cites W1955709889 @default.
- W4292767317 cites W1967343201 @default.
- W4292767317 cites W1969013845 @default.
- W4292767317 cites W1971794028 @default.
- W4292767317 cites W1974976054 @default.
- W4292767317 cites W1975470722 @default.
- W4292767317 cites W1979378430 @default.
- W4292767317 cites W1986034385 @default.
- W4292767317 cites W1986709138 @default.
- W4292767317 cites W1987085702 @default.
- W4292767317 cites W1987159016 @default.
- W4292767317 cites W2029931852 @default.
- W4292767317 cites W2033667161 @default.
- W4292767317 cites W2039341058 @default.
- W4292767317 cites W2043366308 @default.
- W4292767317 cites W2046265708 @default.
- W4292767317 cites W2049908093 @default.
- W4292767317 cites W2061623553 @default.
- W4292767317 cites W2074509666 @default.
- W4292767317 cites W2080907588 @default.
- W4292767317 cites W2085620820 @default.
- W4292767317 cites W2089598607 @default.
- W4292767317 cites W2096410114 @default.
- W4292767317 cites W2106494040 @default.
- W4292767317 cites W2107890140 @default.
- W4292767317 cites W2124823534 @default.
- W4292767317 cites W2129906424 @default.
- W4292767317 cites W2135354199 @default.
- W4292767317 cites W2144705128 @default.
- W4292767317 cites W2144843689 @default.
- W4292767317 cites W2155671648 @default.
- W4292767317 cites W2158173241 @default.
- W4292767317 cites W2164183470 @default.
- W4292767317 cites W2170951443 @default.
- W4292767317 cites W2180201933 @default.
- W4292767317 cites W2337910658 @default.
- W4292767317 cites W2464851698 @default.
- W4292767317 cites W2499062966 @default.
- W4292767317 cites W2504685422 @default.
- W4292767317 cites W2507956816 @default.
- W4292767317 cites W2517065674 @default.
- W4292767317 cites W2530156559 @default.
- W4292767317 cites W2548029597 @default.
- W4292767317 cites W2610078984 @default.
- W4292767317 cites W2734096353 @default.
- W4292767317 cites W2756276968 @default.
- W4292767317 cites W2773277147 @default.
- W4292767317 cites W2794603527 @default.
- W4292767317 cites W2886265361 @default.
- W4292767317 cites W2893655504 @default.
- W4292767317 cites W2896484158 @default.
- W4292767317 cites W2898861879 @default.
- W4292767317 cites W2908620907 @default.
- W4292767317 cites W2911308273 @default.
- W4292767317 cites W2921042471 @default.
- W4292767317 cites W2922610098 @default.
- W4292767317 cites W2935902195 @default.
- W4292767317 cites W2943943635 @default.
- W4292767317 cites W2945549877 @default.
- W4292767317 cites W2947990506 @default.
- W4292767317 cites W2949552933 @default.
- W4292767317 cites W2979089456 @default.
- W4292767317 cites W2980557044 @default.
- W4292767317 cites W2996226482 @default.
- W4292767317 cites W3005590332 @default.
- W4292767317 cites W3006281336 @default.
- W4292767317 cites W3011054918 @default.
- W4292767317 cites W3049081947 @default.
- W4292767317 cites W3096405510 @default.
- W4292767317 cites W3107527779 @default.