FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292775090> ?p ?o ?g. }

• W4292775090 abstract "Abstract Central nervous system alterations was described in Chagas disease in both human and experimental models, leading to meningoencephalitis, stroke and cognitive impairment. Recently, our group demonstrated that acute infection by Trypanossoma cruzi leads to cerebral microvasculophaty in mice with endothelial dysfunction, capillary rarefaction, increased rolling and leukocyte adhesion. Only benznidazole and nifurtimox are available for clinical treatment, they have an efficiency of 80% in the acute phase and less than 20% in chronic phase. However, the effect of these drugs on brain microcirculation has not yet been evaluated. We hypothesized that early treatment with benznidazole could protect brain microcirculation during acute experimental Chagas disease. Swiss Webster mice were inoculated with 10 4 trypomastigotes forms of T. cruzi , and after 24 h they were treated with 50 or 100 mg/kg/day of benznidazole for 14 consecutive days. In untreated infected mice, we observed cerebral microvascular rarefaction, increase in leukocyte rolling and adhesion, reduced cerebral blood flow, and increased CD3 + and F4-80 + cells in brain tissue. Early treatment with benznidazole at 100mg/kg/day and 50mg/kg/day prevented the occurrence of the alterations mentioned. Here, we show that BZ is able to protect the microcirculation and reduced brain inflammation in acute experimental Chagas disease." @default.
• W4292775090 created "2022-08-23" @default.
• W4292775090 creator A5014139287 @default.
• W4292775090 creator A5015295735 @default.
• W4292775090 creator A5035625466 @default.
• W4292775090 creator A5051352877 @default.
• W4292775090 creator A5054699135 @default.
• W4292775090 creator A5063623010 @default.
• W4292775090 creator A5068724265 @default.
• W4292775090 creator A5069979836 @default.
• W4292775090 creator A5080310506 @default.
• W4292775090 date "2022-08-23" @default.
• W4292775090 modified "2023-09-26" @default.
• W4292775090 title "Effect of benznidazole on cerebral microcirculation during acute Trypanosoma cruzi infection in mice" @default.
• W4292775090 cites W1897869809 @default.
• W4292775090 cites W1965964052 @default.
• W4292775090 cites W1974773663 @default.
• W4292775090 cites W1975055427 @default.
• W4292775090 cites W2000050352 @default.
• W4292775090 cites W2000235893 @default.
• W4292775090 cites W2007608479 @default.
• W4292775090 cites W2018456623 @default.
• W4292775090 cites W2030867626 @default.
• W4292775090 cites W2036097029 @default.
• W4292775090 cites W2049102964 @default.
• W4292775090 cites W2056591660 @default.
• W4292775090 cites W2057815635 @default.
• W4292775090 cites W2083062544 @default.
• W4292775090 cites W2088600201 @default.
• W4292775090 cites W2101882858 @default.
• W4292775090 cites W2113729154 @default.
• W4292775090 cites W2118200665 @default.
• W4292775090 cites W2122966723 @default.
• W4292775090 cites W2134072362 @default.
• W4292775090 cites W2148446876 @default.
• W4292775090 cites W2311787713 @default.
• W4292775090 cites W2414034279 @default.
• W4292775090 cites W2586846067 @default.
• W4292775090 cites W2750468453 @default.
• W4292775090 cites W3022268677 @default.
• W4292775090 cites W3140504176 @default.
• W4292775090 doi "https://doi.org/10.21203/rs.3.rs-1910657/v1" @default.
• W4292775090 hasPublicationYear "2022" @default.
• W4292775090 type Work @default.
• W4292775090 citedByCount "0" @default.
• W4292775090 crossrefType "posted-content" @default.
• W4292775090 hasAuthorship W4292775090A5014139287 @default.
• W4292775090 hasAuthorship W4292775090A5015295735 @default.
• W4292775090 hasAuthorship W4292775090A5035625466 @default.
• W4292775090 hasAuthorship W4292775090A5051352877 @default.
• W4292775090 hasAuthorship W4292775090A5054699135 @default.
• W4292775090 hasAuthorship W4292775090A5063623010 @default.
• W4292775090 hasAuthorship W4292775090A5068724265 @default.
• W4292775090 hasAuthorship W4292775090A5069979836 @default.
• W4292775090 hasAuthorship W4292775090A5080310506 @default.
• W4292775090 hasBestOaLocation W42927750901 @default.
• W4292775090 hasConcept C112418997 @default.
• W4292775090 hasConcept C126322002 @default.
• W4292775090 hasConcept C12722491 @default.
• W4292775090 hasConcept C136764020 @default.
• W4292775090 hasConcept C157767197 @default.
• W4292775090 hasConcept C203014093 @default.
• W4292775090 hasConcept C2775867548 @default.
• W4292775090 hasConcept C2776171842 @default.
• W4292775090 hasConcept C2777625466 @default.
• W4292775090 hasConcept C2778048844 @default.
• W4292775090 hasConcept C2778371730 @default.
• W4292775090 hasConcept C2781049234 @default.
• W4292775090 hasConcept C41008148 @default.
• W4292775090 hasConcept C42219234 @default.
• W4292775090 hasConcept C71924100 @default.
• W4292775090 hasConcept C71928629 @default.
• W4292775090 hasConcept C98274493 @default.
• W4292775090 hasConceptScore W4292775090C112418997 @default.
• W4292775090 hasConceptScore W4292775090C126322002 @default.
• W4292775090 hasConceptScore W4292775090C12722491 @default.
• W4292775090 hasConceptScore W4292775090C136764020 @default.
• W4292775090 hasConceptScore W4292775090C157767197 @default.
• W4292775090 hasConceptScore W4292775090C203014093 @default.
• W4292775090 hasConceptScore W4292775090C2775867548 @default.
• W4292775090 hasConceptScore W4292775090C2776171842 @default.
• W4292775090 hasConceptScore W4292775090C2777625466 @default.
• W4292775090 hasConceptScore W4292775090C2778048844 @default.
• W4292775090 hasConceptScore W4292775090C2778371730 @default.
• W4292775090 hasConceptScore W4292775090C2781049234 @default.
• W4292775090 hasConceptScore W4292775090C41008148 @default.
• W4292775090 hasConceptScore W4292775090C42219234 @default.
• W4292775090 hasConceptScore W4292775090C71924100 @default.
• W4292775090 hasConceptScore W4292775090C71928629 @default.
• W4292775090 hasConceptScore W4292775090C98274493 @default.
• W4292775090 hasLocation W42927750901 @default.
• W4292775090 hasOpenAccess W4292775090 @default.
• W4292775090 hasPrimaryLocation W42927750901 @default.
• W4292775090 hasRelatedWork W2327321986 @default.
• W4292775090 hasRelatedWork W2330586706 @default.
• W4292775090 hasRelatedWork W2472890915 @default.
• W4292775090 hasRelatedWork W2561163210 @default.
• W4292775090 hasRelatedWork W2778704312 @default.
• W4292775090 hasRelatedWork W2913668685 @default.
• W4292775090 hasRelatedWork W2974224170 @default.

• next