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- W4292849299 abstract "Cellular senescence is a highly stable cell‐cycle arrest induced by DNA damage and various cellular stresses. Recently, we have revealed that lymphocyte antigen 6 complex, locus D (LY6D) is responsible for senescence‐inducing stress‐evoked vacuole formation through induction of Src family kinase (SFK)‐mediated macropinocytosis. However, the signaling molecule(s) transducing the macropinocytosis signal from extracellular LY6D to the cytoplasmic SFK are unknown. In this study, we identified integrin β1, a transmembrane signaling protein, as an interactor of LY6D by proteomic analysis and co‐immunoprecipitation assays. Inhibition of integrin β1 impaired LY6D‐induced macropinocytosis, and integrin β1 activated SFK through focal adhesion kinase to mediate macropinocytosis. These results indicate that integrin β1 is a crucial mediator of the LY6D‐induced vacuole formation in senescent cells." @default.
- W4292849299 created "2022-08-24" @default.
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- W4292849299 date "2022-09-02" @default.
- W4292849299 modified "2023-10-15" @default.
- W4292849299 title "Integrin β1 transduces the signal for <scp>LY6D</scp>‐induced macropinocytosis and mediates senescence‐inducing stress‐evoked vacuole formation via <scp>FAK</scp>" @default.
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- W4292849299 doi "https://doi.org/10.1002/1873-3468.14477" @default.
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