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• W4292858528 endingPage "1093" @default.
• W4292858528 startingPage "1083" @default.
• W4292858528 abstract "Schizophrenia is widely recognized as a neurodevelopmental disorder. Abnormal cortical development in otherwise typically developing children and adolescents may be revealed using polygenic risk scoring for schizophrenia (PRS-SCZ). We assessed PRS-SCZ and cortical morphometry in typically developing children and adolescents (3–21 years, 46.8% female) using whole genome genotyping and T1-weighted MRI (n=390) from the Pediatric Imaging, Neurocognition and Genetics (PING) cohort. We contextualised the findings using (i) age-matched transcriptomics, (ii) histologically-defined cytoarchitectural types and functionally-defined networks, (iii) case-control differences of schizophrenia and other major psychiatric disorders derived from meta-analytic data of six ENIGMA working groups including a total of 12,876 patients and 15,670 controls. Higher PRS-SCZ was associated with greater cortical thickness, which was most prominent in areas with heightened gene expression of dendrites and synapses. PRS-SCZ related increases in vertex-wise cortical thickness were mainly distributed in association cortical areas, particularly the ventral attention network, while relatively sparing koniocortical type cortex (i.e. primary sensory areas).The large-scale pattern of cortical thickness increases related to PRS-SCZ mirrored the pattern of cortical thinning in schizophrenia and mood-related psychiatric disorders derived from the ENIGMA consortium. Age group models illustrate a possible trajectory from PRS-SCZ associated cortical thickness increases in early childhood towards thinning in late adolescence, the latter resembling the adult brain phenotype of schizophrenia. Collectively, combining imaging-genetics with multi-scale mapping, our work provides novel insight into how genetic risk for schizophrenia impacts the cortex early in life." @default.
• W4292858528 created "2022-08-24" @default.
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• W4292858528 date "2023-10-01" @default.
• W4292858528 modified "2023-10-17" @default.
• W4292858528 title "Schizophrenia Polygenic Risk During Typical Development Reflects Multiscale Cortical Organization" @default.
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• W4292858528 doi "https://doi.org/10.1016/j.bpsgos.2022.08.003" @default.
• W4292858528 hasPublicationYear "2023" @default.
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