FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292865362> ?p ?o ?g. }

• W4292865362 abstract "Clusterin ( CLU ) is an extracellular chaperone involved in reducing amyloid beta (Aβ) toxicity and aggregation. Although previous genome-wide association studies (GWAS) have reported a potential protective effect of CLU on Alzheimer’s disease (AD) patients, how intron-located rs11136000 ( CLU ) affects AD risk by regulating CLU expression remains unknown. In this study, we integrated multiple omics data to construct the regulated pathway of rs11136000- CLU -AD. In step 1, we investigated the effects of variant rs11136000 on AD risk with different genders and diagnostic methods using GWAS summary statistics for AD from International Genomics of Alzheimer’s Project (IGAP) and UK Biobank. In step 2, we assessed the regulation of rs11136000 on CLU expression in AD brain samples from Mayo clinic and controls from Genotype-Tissue Expression (GTEx). In step 3, we investigated the differential gene/protein expression of CLU in AD and controls from four large cohorts. The results showed that rs11136000 T allele reduced AD risk in either clinically diagnosed or proxy AD patients. By using expression quantitative trait loci (eQTL) analysis, rs11136000 variant downregulated CLU expression in 13 normal brain tissues, but upregulated CLU expression in cerebellum and temporal cortex of AD samples. Importantly, CLU was significantly differentially expressed in temporal cortex, dorsolateral prefrontal cortex and anterior prefrontal cortex of AD patients compared with normal controls. Together, rs11136000 may reduce AD risk by regulating CLU expression, which may provide important information about the biological mechanism of rs9848497 in AD progress." @default.
• W4292865362 created "2022-08-24" @default.
• W4292865362 creator A5054449587 @default.
• W4292865362 creator A5090283553 @default.
• W4292865362 date "2022-08-10" @default.
• W4292865362 modified "2023-10-18" @default.
• W4292865362 title "Genetic variant rs11136000 upregulates clusterin expression and reduces Alzheimer’s disease risk" @default.
• W4292865362 cites W1963687105 @default.
• W4292865362 cites W1969874328 @default.
• W4292865362 cites W2006534012 @default.
• W4292865362 cites W2017079501 @default.
• W4292865362 cites W2018922793 @default.
• W4292865362 cites W2039249107 @default.
• W4292865362 cites W2065929647 @default.
• W4292865362 cites W2072682191 @default.
• W4292865362 cites W2086264330 @default.
• W4292865362 cites W2115779804 @default.
• W4292865362 cites W2119519240 @default.
• W4292865362 cites W2121820194 @default.
• W4292865362 cites W2135374418 @default.
• W4292865362 cites W2138746692 @default.
• W4292865362 cites W2152119060 @default.
• W4292865362 cites W2266996964 @default.
• W4292865362 cites W2591809865 @default.
• W4292865362 cites W2617930056 @default.
• W4292865362 cites W2645870360 @default.
• W4292865362 cites W2761275051 @default.
• W4292865362 cites W2786682365 @default.
• W4292865362 cites W2787933178 @default.
• W4292865362 cites W2884825805 @default.
• W4292865362 cites W2908002252 @default.
• W4292865362 cites W2916749909 @default.
• W4292865362 cites W2920516237 @default.
• W4292865362 cites W2921224315 @default.
• W4292865362 cites W2944540884 @default.
• W4292865362 cites W2949785910 @default.
• W4292865362 cites W3025352529 @default.
• W4292865362 cites W3049388525 @default.
• W4292865362 cites W3081376854 @default.
• W4292865362 cites W3098407059 @default.
• W4292865362 cites W3102385171 @default.
• W4292865362 cites W3115346491 @default.
• W4292865362 cites W3125843200 @default.
• W4292865362 cites W3194137039 @default.
• W4292865362 cites W4205884063 @default.
• W4292865362 cites W4211213171 @default.
• W4292865362 cites W4211238543 @default.
• W4292865362 doi "https://doi.org/10.3389/fnins.2022.926830" @default.
• W4292865362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36033622" @default.
• W4292865362 hasPublicationYear "2022" @default.
• W4292865362 type Work @default.
• W4292865362 citedByCount "2" @default.
• W4292865362 countsByYear W42928653622023 @default.
• W4292865362 crossrefType "journal-article" @default.
• W4292865362 hasAuthorship W4292865362A5054449587 @default.
• W4292865362 hasAuthorship W4292865362A5090283553 @default.
• W4292865362 hasBestOaLocation W42928653621 @default.
• W4292865362 hasConcept C104317684 @default.
• W4292865362 hasConcept C106208931 @default.
• W4292865362 hasConcept C126322002 @default.
• W4292865362 hasConcept C135763542 @default.
• W4292865362 hasConcept C153209595 @default.
• W4292865362 hasConcept C168393362 @default.
• W4292865362 hasConcept C169760540 @default.
• W4292865362 hasConcept C169900460 @default.
• W4292865362 hasConcept C190283241 @default.
• W4292865362 hasConcept C2779134260 @default.
• W4292865362 hasConcept C2779476363 @default.
• W4292865362 hasConcept C2781195155 @default.
• W4292865362 hasConcept C502032728 @default.
• W4292865362 hasConcept C54355233 @default.
• W4292865362 hasConcept C71924100 @default.
• W4292865362 hasConcept C86803240 @default.
• W4292865362 hasConceptScore W4292865362C104317684 @default.
• W4292865362 hasConceptScore W4292865362C106208931 @default.
• W4292865362 hasConceptScore W4292865362C126322002 @default.
• W4292865362 hasConceptScore W4292865362C135763542 @default.
• W4292865362 hasConceptScore W4292865362C153209595 @default.
• W4292865362 hasConceptScore W4292865362C168393362 @default.
• W4292865362 hasConceptScore W4292865362C169760540 @default.
• W4292865362 hasConceptScore W4292865362C169900460 @default.
• W4292865362 hasConceptScore W4292865362C190283241 @default.
• W4292865362 hasConceptScore W4292865362C2779134260 @default.
• W4292865362 hasConceptScore W4292865362C2779476363 @default.
• W4292865362 hasConceptScore W4292865362C2781195155 @default.
• W4292865362 hasConceptScore W4292865362C502032728 @default.
• W4292865362 hasConceptScore W4292865362C54355233 @default.
• W4292865362 hasConceptScore W4292865362C71924100 @default.
• W4292865362 hasConceptScore W4292865362C86803240 @default.
• W4292865362 hasLocation W42928653621 @default.
• W4292865362 hasLocation W42928653622 @default.
• W4292865362 hasLocation W42928653623 @default.
• W4292865362 hasOpenAccess W4292865362 @default.
• W4292865362 hasPrimaryLocation W42928653621 @default.
• W4292865362 hasRelatedWork W104925310 @default.
• W4292865362 hasRelatedWork W1995613491 @default.
• W4292865362 hasRelatedWork W2002128513 @default.
• W4292865362 hasRelatedWork W2150283886 @default.
• W4292865362 hasRelatedWork W2750511493 @default.
• W4292865362 hasRelatedWork W2951751247 @default.

• next