Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292865496> ?p ?o ?g. }
- W4292865496 abstract "Aims: Inflammation-driven endothelitis seems to be a hallmark of acute heart failure (AHF) and cardiogenic shock (CS). Endocan, a soluble proteoglycan secreted by the activated endothelium, contributes to inflammation and endothelial dysfunction, but has been scarcely explored in human AHF. We aimed to evaluate serum (S-Endocan) and urinary endocan (U-Endocan) profiles in AHF and CS patients and to correlate them with biomarkers/parameters of inflammation, endothelial activation, cardiovascular dysfunction and prognosis. Methods: Blood and spot urine were collected from patients with AHF ( n = 23) or CS ( n = 25) at days 1–2 (admission), 3-4 and 5-8 and from controls (blood donors, n = 22) at a single time point. S-Endocan, U-Endocan, serum IL-1β, IL-6, tumour necrosis factor-α (S-TNF-α), intercellular adhesion molecule-1 (S-ICAM-1), vascular cell adhesion molecule-1 (S-VCAM-1) and E-selectin were determined by ELISA or multiplex immunoassays. Serum C-reactive protein (S-CRP), plasma B-type natriuretic peptide (P-BNP) and high-sensitivity troponin I (P-hs-trop I), lactate, urea, creatinine and urinary proteins, as well as prognostic scores (APACHE II, SAPS II) and echocardiographic left ventricular ejection fraction (LVEF) were also evaluated. Results: Admission S-Endocan was higher in both patient groups, with CS presenting greater values than AHF (AHF and CS vs. Controls, p < 0.001; CS vs . AHF, p < 0.01). Admission U-Endocan was only higher in CS patients ( p < 0.01 vs . Controls). At admission, S-VCAM-1, S-IL-6 and S-TNF-α were also higher in both patient groups but there were no differences in S-E-selectin and S-IL-1β among the groups, nor in P-BNP, S-CRP or renal function between AHF and CS. Neither endocan nor other endothelial and inflammatory markers were reduced during hospitalization ( p > 0.05). S-Endocan positively correlated with S-VCAM-1, S-IL-6, S-CRP, APACHE II and SAPS II scores and was positively associated with P-BNP in multivariate analyses. Admission S-Endocan raised in line with LVEF impairment ( p = 0.008 for linear trend). Conclusion: Admission endocan significantly increases across AHF spectrum. The lack of reduction in endothelial and inflammatory markers throughout hospitalization suggests a perpetuation of endothelial dysfunction and inflammation. S-Endocan appears to be a biomarker of endothelitis and a putative therapeutic target in AHF and CS, given its association with LVEF impairment and P-BNP and its positive correlation with prognostic scores." @default.
- W4292865496 created "2022-08-24" @default.
- W4292865496 creator A5004366382 @default.
- W4292865496 creator A5006309645 @default.
- W4292865496 creator A5008967853 @default.
- W4292865496 creator A5013148932 @default.
- W4292865496 creator A5016473165 @default.
- W4292865496 creator A5017617232 @default.
- W4292865496 creator A5036923124 @default.
- W4292865496 creator A5039718670 @default.
- W4292865496 creator A5039879434 @default.
- W4292865496 creator A5044163428 @default.
- W4292865496 creator A5060767599 @default.
- W4292865496 creator A5062264742 @default.
- W4292865496 creator A5067607991 @default.
- W4292865496 creator A5070297265 @default.
- W4292865496 creator A5084089641 @default.
- W4292865496 date "2022-08-11" @default.
- W4292865496 modified "2023-10-18" @default.
- W4292865496 title "Endothelitis profile in acute heart failure and cardiogenic shock patients: Endocan as a potential novel biomarker and putative therapeutic target" @default.
- W4292865496 cites W123651476 @default.
- W4292865496 cites W1484146179 @default.
- W4292865496 cites W1975402385 @default.
- W4292865496 cites W1984353641 @default.
- W4292865496 cites W2002762030 @default.
- W4292865496 cites W2002877406 @default.
- W4292865496 cites W2007591654 @default.
- W4292865496 cites W2017967250 @default.
- W4292865496 cites W2018065665 @default.
- W4292865496 cites W2021448917 @default.
- W4292865496 cites W2028148874 @default.
- W4292865496 cites W2030812638 @default.
- W4292865496 cites W2049978396 @default.
- W4292865496 cites W2056299656 @default.
- W4292865496 cites W2066249273 @default.
- W4292865496 cites W2075122399 @default.
- W4292865496 cites W2075978162 @default.
- W4292865496 cites W2076066950 @default.
- W4292865496 cites W2080231335 @default.
- W4292865496 cites W2089659929 @default.
- W4292865496 cites W2092417794 @default.
- W4292865496 cites W2103701188 @default.
- W4292865496 cites W2113698123 @default.
- W4292865496 cites W2113835063 @default.
- W4292865496 cites W2119254117 @default.
- W4292865496 cites W2122622124 @default.
- W4292865496 cites W2123950519 @default.
- W4292865496 cites W2125772724 @default.
- W4292865496 cites W2138385114 @default.
- W4292865496 cites W2147895125 @default.
- W4292865496 cites W2155018999 @default.
- W4292865496 cites W2155965977 @default.
- W4292865496 cites W2160224740 @default.
- W4292865496 cites W2164846898 @default.
- W4292865496 cites W2166504467 @default.
- W4292865496 cites W2167760816 @default.
- W4292865496 cites W2189764970 @default.
- W4292865496 cites W2275954339 @default.
- W4292865496 cites W2472746779 @default.
- W4292865496 cites W2551717479 @default.
- W4292865496 cites W2557404996 @default.
- W4292865496 cites W2563162818 @default.
- W4292865496 cites W2577668070 @default.
- W4292865496 cites W2606825442 @default.
- W4292865496 cites W2607031541 @default.
- W4292865496 cites W2610130212 @default.
- W4292865496 cites W2611341068 @default.
- W4292865496 cites W2618504747 @default.
- W4292865496 cites W2620823929 @default.
- W4292865496 cites W2727919258 @default.
- W4292865496 cites W2759135478 @default.
- W4292865496 cites W2768040328 @default.
- W4292865496 cites W2770851640 @default.
- W4292865496 cites W2771547616 @default.
- W4292865496 cites W2777204537 @default.
- W4292865496 cites W2792937010 @default.
- W4292865496 cites W2800947392 @default.
- W4292865496 cites W2809541034 @default.
- W4292865496 cites W2883526230 @default.
- W4292865496 cites W2898336414 @default.
- W4292865496 cites W2899841238 @default.
- W4292865496 cites W2902380100 @default.
- W4292865496 cites W2913705661 @default.
- W4292865496 cites W2916506247 @default.
- W4292865496 cites W2933429013 @default.
- W4292865496 cites W2937704642 @default.
- W4292865496 cites W2938241955 @default.
- W4292865496 cites W2945001498 @default.
- W4292865496 cites W2947972779 @default.
- W4292865496 cites W2954844613 @default.
- W4292865496 cites W2955729578 @default.
- W4292865496 cites W2963728831 @default.
- W4292865496 cites W2964727817 @default.
- W4292865496 cites W2965966084 @default.
- W4292865496 cites W2983748684 @default.
- W4292865496 cites W2990828435 @default.
- W4292865496 cites W3003995118 @default.
- W4292865496 cites W3045270715 @default.
- W4292865496 cites W3118783530 @default.
- W4292865496 cites W3127576695 @default.