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- W4292868049 endingPage "919" @default.
- W4292868049 startingPage "906" @default.
- W4292868049 abstract "While vaccines remain at the forefront of global healthcare responses, pioneering therapeutics against SARS-CoV-2 are expected to fill the gaps for waning immunity. Rapid development and approval of orally available direct-acting antivirals targeting crucial SARS-CoV-2 proteins marked the beginning of the era of small-molecule drugs for COVID-19. In that regard, the papain-like protease (PLpro) can be considered a major SARS-CoV-2 therapeutic target due to its dual biological role in suppressing host innate immune responses and in ensuring viral replication. Here, we summarize the challenges of targeting PLpro and innovative early-stage PLpro-specific small molecules. We propose that state-of-the-art computer-aided drug design (CADD) methodologies will play a critical role in the discovery of PLpro compounds as a novel class of COVID-19 drugs." @default.
- W4292868049 created "2022-08-24" @default.
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- W4292868049 date "2022-11-01" @default.
- W4292868049 modified "2023-09-30" @default.
- W4292868049 title "Targeting SARS-CoV-2 papain-like protease in the postvaccine era" @default.
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- W4292868049 cites W2784270883 @default.
- W4292868049 cites W2794774007 @default.
- W4292868049 cites W2912171584 @default.
- W4292868049 cites W2920995682 @default.
- W4292868049 cites W2921262115 @default.
- W4292868049 cites W2937307539 @default.
- W4292868049 cites W2940537888 @default.
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- W4292868049 cites W3006759222 @default.
- W4292868049 cites W3015608194 @default.
- W4292868049 cites W3020300207 @default.
- W4292868049 cites W3024964904 @default.
- W4292868049 cites W3035265089 @default.
- W4292868049 cites W3039523373 @default.
- W4292868049 cites W3046218096 @default.
- W4292868049 cites W3046992885 @default.
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- W4292868049 doi "https://doi.org/10.1016/j.tips.2022.08.008" @default.
- W4292868049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36114026" @default.
- W4292868049 hasPublicationYear "2022" @default.
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