FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292876985> ?p ?o ?g. }

• W4292876985 endingPage "138788" @default.
• W4292876985 startingPage "138788" @default.
• W4292876985 abstract "Spinal cord injury (SCI) is a terrible injury of the central nervous system for which there is no ideal treatment in clinic so far. The spinal cord biomimetic scaffolds which mimic the shape and structure of native spinal cord tissue, could effectively promote the repair of SCI. However, current biomimetic scaffolds do not mimic the biological functions, especially the electrical conductivity, of spinal cord tissue, which largely limits the therapeutic effect of SCI. In this study, we have developed novel conductive hydrogels based on gelatin methacrylate (GelMA), hyaluronic acid methacrylate (HAMA) and poly(3,4-ethylenedioxythiophene): sulfonated lignin (PEDOT:LS). The incorporation of PEDOT:LS into GelMA/HAMA hydrogel matrix significantly improved the conductivity of the hydrogels. By precisely regulating the light curing time, the conductive hydrogels showed mechanical properties similar to native spinal cord tissues. Then, the conductive biomimetic scaffolds were fabricated by 3D bioprinting, and the neural stem cells (NSCs) encapsulated in the scaffolds exhibited good survival rate (higher than 90%). Compared to the non-conductive scaffolds reported, the conductive scaffolds remarkably promoted neuronal differentiation of NSCs in vitro. In a rat spinal cord complete transection model, the conductive biomimetic scaffold dramatically promoted the recovery of hindlimb motor function. Immunofluorescence staining results further showed that the conductive biomimetic scaffold effectively promoted the regeneration of neurons at the injury site, reduced the deposition of glial scar, and promoted nerve axon regeneration and myelination. Overall, the 3D bioprinting of the conductive spinal cord biomimetic scaffolds developed in this work represents a promising approach for the stem cell-based treatment of SCI." @default.
• W4292876985 created "2022-08-24" @default.
• W4292876985 creator A5008812639 @default.
• W4292876985 creator A5044901407 @default.
• W4292876985 creator A5053325532 @default.
• W4292876985 creator A5065933032 @default.
• W4292876985 creator A5086859444 @default.
• W4292876985 date "2023-01-01" @default.
• W4292876985 modified "2023-10-16" @default.
• W4292876985 title "3D bioprinted conductive spinal cord biomimetic scaffolds for promoting neuronal differentiation of neural stem cells and repairing of spinal cord injury" @default.
• W4292876985 cites W1935012038 @default.
• W4292876985 cites W1981481147 @default.
• W4292876985 cites W1985006454 @default.
• W4292876985 cites W2045143966 @default.
• W4292876985 cites W2056737276 @default.
• W4292876985 cites W2098737512 @default.
• W4292876985 cites W2107514110 @default.
• W4292876985 cites W2129471941 @default.
• W4292876985 cites W2152163452 @default.
• W4292876985 cites W2155569675 @default.
• W4292876985 cites W2206917580 @default.
• W4292876985 cites W2343740468 @default.
• W4292876985 cites W2554824091 @default.
• W4292876985 cites W2582829385 @default.
• W4292876985 cites W2802189972 @default.
• W4292876985 cites W2804065022 @default.
• W4292876985 cites W2887331259 @default.
• W4292876985 cites W2888183927 @default.
• W4292876985 cites W2895422828 @default.
• W4292876985 cites W2902168385 @default.
• W4292876985 cites W2902666346 @default.
• W4292876985 cites W2905083102 @default.
• W4292876985 cites W2908359749 @default.
• W4292876985 cites W2912790513 @default.
• W4292876985 cites W2914099446 @default.
• W4292876985 cites W2915547407 @default.
• W4292876985 cites W2934689771 @default.
• W4292876985 cites W2944997993 @default.
• W4292876985 cites W2947742621 @default.
• W4292876985 cites W2964989439 @default.
• W4292876985 cites W2983517140 @default.
• W4292876985 cites W2989039410 @default.
• W4292876985 cites W3006443690 @default.
• W4292876985 cites W3088574300 @default.
• W4292876985 cites W3103802885 @default.
• W4292876985 cites W3104511537 @default.
• W4292876985 cites W3110821710 @default.
• W4292876985 cites W3112169826 @default.
• W4292876985 cites W3121528889 @default.
• W4292876985 cites W3146426336 @default.
• W4292876985 cites W3167880361 @default.
• W4292876985 cites W3177609066 @default.
• W4292876985 cites W3184836033 @default.
• W4292876985 cites W3205004203 @default.
• W4292876985 cites W3208319694 @default.
• W4292876985 cites W4200576944 @default.
• W4292876985 cites W4224987903 @default.
• W4292876985 cites W48639200 @default.
• W4292876985 doi "https://doi.org/10.1016/j.cej.2022.138788" @default.
• W4292876985 hasPublicationYear "2023" @default.
• W4292876985 type Work @default.
• W4292876985 citedByCount "17" @default.
• W4292876985 countsByYear W42928769852023 @default.
• W4292876985 crossrefType "journal-article" @default.
• W4292876985 hasAuthorship W4292876985A5008812639 @default.
• W4292876985 hasAuthorship W4292876985A5044901407 @default.
• W4292876985 hasAuthorship W4292876985A5053325532 @default.
• W4292876985 hasAuthorship W4292876985A5065933032 @default.
• W4292876985 hasAuthorship W4292876985A5086859444 @default.
• W4292876985 hasConcept C108586683 @default.
• W4292876985 hasConcept C136229726 @default.
• W4292876985 hasConcept C136834591 @default.
• W4292876985 hasConcept C169760540 @default.
• W4292876985 hasConcept C171056886 @default.
• W4292876985 hasConcept C185592680 @default.
• W4292876985 hasConcept C187761678 @default.
• W4292876985 hasConcept C188027245 @default.
• W4292876985 hasConcept C192562407 @default.
• W4292876985 hasConcept C2778334475 @default.
• W4292876985 hasConcept C2780775167 @default.
• W4292876985 hasConcept C28328180 @default.
• W4292876985 hasConcept C49892992 @default.
• W4292876985 hasConcept C71924100 @default.
• W4292876985 hasConcept C86803240 @default.
• W4292876985 hasConcept C89429830 @default.
• W4292876985 hasConcept C95444343 @default.
• W4292876985 hasConceptScore W4292876985C108586683 @default.
• W4292876985 hasConceptScore W4292876985C136229726 @default.
• W4292876985 hasConceptScore W4292876985C136834591 @default.
• W4292876985 hasConceptScore W4292876985C169760540 @default.
• W4292876985 hasConceptScore W4292876985C171056886 @default.
• W4292876985 hasConceptScore W4292876985C185592680 @default.
• W4292876985 hasConceptScore W4292876985C187761678 @default.
• W4292876985 hasConceptScore W4292876985C188027245 @default.
• W4292876985 hasConceptScore W4292876985C192562407 @default.
• W4292876985 hasConceptScore W4292876985C2778334475 @default.
• W4292876985 hasConceptScore W4292876985C2780775167 @default.
• W4292876985 hasConceptScore W4292876985C28328180 @default.

• next