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• W4292939394 endingPage "120904" @default.
• W4292939394 startingPage "120904" @default.
• W4292939394 abstract "Most of the published experiments about carbimazole (CMZ)-induced testicular injury are constructed in normal healthy animals, which lakes the translational identification. Despite metformin (MET) having advantageous effects on injured testicles, its impact on thyroid function is arguable. In the current levothyroxine (LT4)/CMZ model, Wistar rats were primed by LT4 for sixty days. CMZ was then given individually or simultaneously with different doses of MET, 100, 200, and 400 mg, daily for thirty days. Serum was assessed for thyroid profile panel, sex hormones, and gonadotropin levels. Testicular tissues were examined for steroidogenesis, spermatogenesis, inflammation, and apoptosis. Histopathology of thyroid and testes were examined, besides thyroidal nuclear factor (NF)-kB expression. MET in a dose-response manner improved the LT4/CMZ-induced testicular toxicity by increasing the steroidogenic acute regulatory protein (StAR), and 17-β-hydroxysteroid dehydrogenase (17βHSD) activities, the proliferating cell nuclear antigen (PCNA), sperm count and motility, sex hormones, and gonadotropin levels. MET-400 mg markedly decreased the elevated NF-kB expressions, tumour necrosis factor (TNF)-α, caspase-3, and BAX, and increased BCL-2. LT4/CMZ could be used as translational animal modelling. MET displayed a dose-dependent ameliorative effect on the LT4/CMZ model without significant harmful effects on thyroid functions. MET-testicular protective roles in diabetics with thyroidal diseases should be explored." @default.
• W4292939394 created "2022-08-24" @default.
• W4292939394 creator A5018246085 @default.
• W4292939394 creator A5043382938 @default.
• W4292939394 creator A5050486292 @default.
• W4292939394 creator A5057896372 @default.
• W4292939394 creator A5073074017 @default.
• W4292939394 creator A5085905317 @default.
• W4292939394 creator A5090288549 @default.
• W4292939394 date "2022-10-01" @default.
• W4292939394 modified "2023-09-27" @default.
• W4292939394 title "Metformin alleviates the dysregulated testicular steroidogenesis and spermatogenesis induced by carbimazole in levothyroxine-primed rats" @default.
• W4292939394 cites W1430832764 @default.
• W4292939394 cites W1965974783 @default.
• W4292939394 cites W1967194842 @default.
• W4292939394 cites W1969658536 @default.
• W4292939394 cites W1979100644 @default.
• W4292939394 cites W1979756450 @default.
• W4292939394 cites W1985199798 @default.
• W4292939394 cites W1986205831 @default.
• W4292939394 cites W1986512051 @default.
• W4292939394 cites W1987217742 @default.
• W4292939394 cites W1991883197 @default.
• W4292939394 cites W1994930939 @default.
• W4292939394 cites W1999767740 @default.
• W4292939394 cites W2004341421 @default.
• W4292939394 cites W2005227740 @default.
• W4292939394 cites W2008020567 @default.
• W4292939394 cites W2011793392 @default.
• W4292939394 cites W2012312748 @default.
• W4292939394 cites W2014783542 @default.
• W4292939394 cites W2015570339 @default.
• W4292939394 cites W2023568379 @default.
• W4292939394 cites W2025997558 @default.
• W4292939394 cites W2040509452 @default.
• W4292939394 cites W2045662303 @default.
• W4292939394 cites W2045861459 @default.
• W4292939394 cites W2047096573 @default.
• W4292939394 cites W2050447866 @default.
• W4292939394 cites W2058378922 @default.
• W4292939394 cites W2062852595 @default.
• W4292939394 cites W2064332932 @default.
• W4292939394 cites W2067852792 @default.
• W4292939394 cites W2069511021 @default.
• W4292939394 cites W2083172003 @default.
• W4292939394 cites W2084822472 @default.
• W4292939394 cites W2094051883 @default.
• W4292939394 cites W2094621870 @default.
• W4292939394 cites W2097644723 @default.
• W4292939394 cites W2098822179 @default.
• W4292939394 cites W2114648205 @default.
• W4292939394 cites W2119792925 @default.
• W4292939394 cites W2122254529 @default.
• W4292939394 cites W2128016220 @default.
• W4292939394 cites W2128296469 @default.
• W4292939394 cites W2129786180 @default.
• W4292939394 cites W2131093877 @default.
• W4292939394 cites W2134876608 @default.
• W4292939394 cites W2140112227 @default.
• W4292939394 cites W2145578763 @default.
• W4292939394 cites W2147625870 @default.
• W4292939394 cites W2153376795 @default.
• W4292939394 cites W2157302214 @default.
• W4292939394 cites W2164125044 @default.
• W4292939394 cites W2164577763 @default.
• W4292939394 cites W2164856298 @default.
• W4292939394 cites W2167817195 @default.
• W4292939394 cites W2171820243 @default.
• W4292939394 cites W2209286141 @default.
• W4292939394 cites W2318666698 @default.
• W4292939394 cites W2417801184 @default.
• W4292939394 cites W2474633195 @default.
• W4292939394 cites W2510904029 @default.
• W4292939394 cites W2611124498 @default.
• W4292939394 cites W2720137316 @default.
• W4292939394 cites W2737858988 @default.
• W4292939394 cites W2768819633 @default.
• W4292939394 cites W2791383766 @default.
• W4292939394 cites W2792411929 @default.
• W4292939394 cites W2792810242 @default.
• W4292939394 cites W2794346468 @default.
• W4292939394 cites W2888546777 @default.
• W4292939394 cites W2902422411 @default.
• W4292939394 cites W2902952748 @default.
• W4292939394 cites W2993542116 @default.
• W4292939394 cites W3004849737 @default.
• W4292939394 cites W3014703933 @default.
• W4292939394 cites W3015615378 @default.
• W4292939394 cites W3038042517 @default.
• W4292939394 cites W3038567581 @default.
• W4292939394 cites W3042013683 @default.
• W4292939394 cites W3043521650 @default.
• W4292939394 cites W3087387309 @default.
• W4292939394 cites W3105200265 @default.
• W4292939394 cites W31337204 @default.
• W4292939394 cites W3174684953 @default.
• W4292939394 cites W3191020894 @default.
• W4292939394 cites W4205283399 @default.

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