FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292941483> ?p ?o ?g. }

• W4292941483 endingPage "136" @default.
• W4292941483 startingPage "128" @default.
• W4292941483 abstract "Nitric oxide (NO) is a fascinating signalling molecule implicated in a plethora of biological functions, especially at the synaptic level. Exploring neurotransmission in the hippocampus could be instrumental in the individuation of putative targets for nitric-oxide mediated neuromodulation, especially in terms of the potential repercussions on fundamental processes i.e. synaptic plasticity and excitability-related phenomena. Among these targets, endovanilloid signalling constitutes an object of study since Transient Receptors Vanilloid type 1 (TRPV1) channels possess a NO-sensitive gate modulating its activation. Also, NO has been referred to as a mediator for numerous endocannabinoid effects. Notwithstanding, the linkage between TRPV1 and NO systems in neuromodulation still remains elusive. To this end, we aim at investigating the involvement of TRPV1 in nitric oxide-mediated influence on hippocampal processes. Electrophysiological whole-cell recordings in CA1 pyramidal neurons were applied to evaluate excitatory neurotransmission in rat brain slices. Indeed, miniature excitatory postsynaptic currents (mEPSCs) were analysed upon pharmacological manipulation of TRPV1 and NO signalling pathways. In detail, only the administration of the specific TRPV1 exogenous agonist - capsaicin - reduced the frequency and amplitude of mEPSC similarly to the inhibitor of neuronal nitric oxide synthase (nNOS), 7-nitroindazole (7NI). In contrast, capsazepine, TRPV1 antagonist, does not influence excitatory transmission. The combined TRPV1 activation and nNOS blockade confirm the presence of a putative common mechanism. When we administered the endovanilloid-endocannabinoid ligand, i.e. anandamide, we unveiled a potentiation of neurotransmission that was selectively reverted by 7NI. Our data suggest that nitric oxide influences TRPV1 hippocampal signalling since these channels are not constitutively active, but can be on-demand activated to modulate excitation in CA1 pyramidal neurons, and that this effect is linked to nitric oxide production." @default.
• W4292941483 created "2022-08-24" @default.
• W4292941483 creator A5002018004 @default.
• W4292941483 creator A5030942293 @default.
• W4292941483 creator A5045085140 @default.
• W4292941483 creator A5050536895 @default.
• W4292941483 creator A5085448299 @default.
• W4292941483 creator A5091227500 @default.
• W4292941483 date "2022-10-01" @default.
• W4292941483 modified "2023-09-23" @default.
• W4292941483 title "TRPV1 channels in nitric oxide-mediated signalling: insight on excitatory transmission in rat CA1 pyramidal neurons" @default.
• W4292941483 cites W1569255175 @default.
• W4292941483 cites W1972858136 @default.
• W4292941483 cites W1973150838 @default.
• W4292941483 cites W1975732344 @default.
• W4292941483 cites W1977223788 @default.
• W4292941483 cites W1978648371 @default.
• W4292941483 cites W1982604009 @default.
• W4292941483 cites W1982946237 @default.
• W4292941483 cites W1991818986 @default.
• W4292941483 cites W1994714777 @default.
• W4292941483 cites W2006401652 @default.
• W4292941483 cites W2010864051 @default.
• W4292941483 cites W2019659882 @default.
• W4292941483 cites W2028727710 @default.
• W4292941483 cites W2042320851 @default.
• W4292941483 cites W2050519455 @default.
• W4292941483 cites W2052559631 @default.
• W4292941483 cites W2053251168 @default.
• W4292941483 cites W2065489888 @default.
• W4292941483 cites W2082117294 @default.
• W4292941483 cites W2083925864 @default.
• W4292941483 cites W2084784577 @default.
• W4292941483 cites W2085802434 @default.
• W4292941483 cites W2089362566 @default.
• W4292941483 cites W2098481087 @default.
• W4292941483 cites W2099661683 @default.
• W4292941483 cites W2101814309 @default.
• W4292941483 cites W2129597960 @default.
• W4292941483 cites W2141870183 @default.
• W4292941483 cites W2145521476 @default.
• W4292941483 cites W2168499817 @default.
• W4292941483 cites W2205385855 @default.
• W4292941483 cites W2259674144 @default.
• W4292941483 cites W2606716659 @default.
• W4292941483 cites W2737261996 @default.
• W4292941483 cites W2770890085 @default.
• W4292941483 cites W2789404284 @default.
• W4292941483 cites W2797699950 @default.
• W4292941483 cites W2830054004 @default.
• W4292941483 cites W2989686260 @default.
• W4292941483 cites W2999291880 @default.
• W4292941483 cites W3003927600 @default.
• W4292941483 cites W3004444550 @default.
• W4292941483 cites W3085147824 @default.
• W4292941483 cites W3125970254 @default.
• W4292941483 cites W3172213311 @default.
• W4292941483 cites W3216436760 @default.
• W4292941483 cites W4224221371 @default.
• W4292941483 cites W874389951 @default.
• W4292941483 cites W944531411 @default.
• W4292941483 doi "https://doi.org/10.1016/j.freeradbiomed.2022.08.025" @default.
• W4292941483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36029909" @default.
• W4292941483 hasPublicationYear "2022" @default.
• W4292941483 type Work @default.
• W4292941483 citedByCount "5" @default.
• W4292941483 countsByYear W42929414832022 @default.
• W4292941483 countsByYear W42929414832023 @default.
• W4292941483 crossrefType "journal-article" @default.
• W4292941483 hasAuthorship W4292941483A5002018004 @default.
• W4292941483 hasAuthorship W4292941483A5030942293 @default.
• W4292941483 hasAuthorship W4292941483A5045085140 @default.
• W4292941483 hasAuthorship W4292941483A5050536895 @default.
• W4292941483 hasAuthorship W4292941483A5085448299 @default.
• W4292941483 hasAuthorship W4292941483A5091227500 @default.
• W4292941483 hasConcept C112592302 @default.
• W4292941483 hasConcept C155164980 @default.
• W4292941483 hasConcept C160145004 @default.
• W4292941483 hasConcept C169760540 @default.
• W4292941483 hasConcept C170493617 @default.
• W4292941483 hasConcept C17077164 @default.
• W4292941483 hasConcept C178790620 @default.
• W4292941483 hasConcept C185592680 @default.
• W4292941483 hasConcept C200170125 @default.
• W4292941483 hasConcept C25274449 @default.
• W4292941483 hasConcept C2780375056 @default.
• W4292941483 hasConcept C46721173 @default.
• W4292941483 hasConcept C519581460 @default.
• W4292941483 hasConcept C529278444 @default.
• W4292941483 hasConcept C55493867 @default.
• W4292941483 hasConcept C86803240 @default.
• W4292941483 hasConcept C98229152 @default.
• W4292941483 hasConceptScore W4292941483C112592302 @default.
• W4292941483 hasConceptScore W4292941483C155164980 @default.
• W4292941483 hasConceptScore W4292941483C160145004 @default.
• W4292941483 hasConceptScore W4292941483C169760540 @default.
• W4292941483 hasConceptScore W4292941483C170493617 @default.
• W4292941483 hasConceptScore W4292941483C17077164 @default.

• next