Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292984638> ?p ?o ?g. }
- W4292984638 abstract "Abstract Improving muscle function has great potential to improve the quality of life. To identify novel regulators of skeletal muscle metabolism and function, we performed a proteomic analysis of gastrocnemius muscle from 73 genetically distinct inbred mouse strains, and integrated the data with genomics and >300 molecular/phenotypic traits via quantitative trait loci mapping and correlation network analysis. These data identified thousands of associations between protein abundance and phenotypes and can be accessed online ( https://muscle.coffeeprot.com/ ) to identify regulators of muscle function. We used this resource to prioritize targets for a functional genomic screen in human bioengineered skeletal muscle. This identified several negative regulators of muscle function including UFC1, an E2 ligase for protein UFMylation. We show UFMylation is up-regulated in a mouse model of amyotrophic lateral sclerosis, a disease that involves muscle atrophy. Furthermore, in vivo knockdown of UFMylation increased contraction force, implicating its role as a negative regulator of skeletal muscle function." @default.
- W4292984638 created "2022-08-25" @default.
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- W4292984638 date "2022-08-22" @default.
- W4292984638 modified "2023-09-23" @default.
- W4292984638 title "Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function" @default.
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