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- W4293013191 abstract "Summary The expression of MHCII by intestinal epithelial cells (IEC) determines the severity of intestinal immunopathological reactions. However, the function of MHCII on IEC under homeostatic conditions remains elusive. Here we report that MHCII expression on IECs is a hallmark of an adaptive wave of homeostatic intestinal immune responses to commensal segmented filamentous bacteria (SFB). Focusing on SFB-driven responses, we describe the expression pattern of MHCII and the associated antigen processing machinery among IEC subpopulations along with the cellular network that regulates MHCII induction. Furthermore, we show that SFB induce the accumulation of SFB-specific intraepithelial lymphocytes (IELs) that originate from conventional CD4 + T-cells. Importantly, induced IELs are dependent on the epithelial MHCII. Finally, we demonstrate that both epithelial MHCII and the IEL functionality regulate the epithelial turnover. This study describes the organization of a commensal-targeted, IEL-driven immune response that is controlled by IEC antigen presentation and ultimately regulates IEC turnover." @default.
- W4293013191 created "2022-08-25" @default.
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- W4293013191 date "2022-08-22" @default.
- W4293013191 modified "2023-10-18" @default.
- W4293013191 title "Epithelial antigen presentation controls commensal-specific intraepithelial T-cells in the gut" @default.
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- W4293013191 doi "https://doi.org/10.1101/2022.08.21.504672" @default.
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