Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293030271> ?p ?o ?g. }
- W4293030271 endingPage "9424" @default.
- W4293030271 startingPage "9424" @default.
- W4293030271 abstract "Diabetic macular edema (DME) and neovascular age-related macular degeneration (nAMD) are common retinal vascular diseases responsible for most blindness in the working-age and older population in developed countries. Currently, anti-VEGF agents that block VEGF family ligands, including ranibizumab, bevacizumab (off-label use), brolucizumab, and aflibercept, are the first-line treatment for nAMD and DME. However, due to the complex pathophysiological background of nAMD and DME, non-response, resistance during anti-VEGF therapy, and relapses of the disease are still observed. Moreover, frequent injections are a psychological and economic burden for patients, leading to inadequate adhesion to therapy and a higher risk of complications. Therefore, therapeutic methods are strongly needed to develop and improve, allowing for more satisfactory disease management and lower treatment burden. Currently, the Ang/Tie-2 pathway is a promising therapeutic target for retinal vascular diseases. Faricimab is the first bispecific monoclonal antibody for intravitreal use that can neutralize VEGF and Ang-2. Due to the prolonged activity, faricimab allows extending the interval between successive injections up to three or four months in nAMD and DME patients, which can be a significant benefit for patients and an alternative to implanted drug delivery systems." @default.
- W4293030271 created "2022-08-25" @default.
- W4293030271 creator A5001014754 @default.
- W4293030271 creator A5029950731 @default.
- W4293030271 creator A5074096671 @default.
- W4293030271 date "2022-08-20" @default.
- W4293030271 modified "2023-09-30" @default.
- W4293030271 title "Aflibercept versus Faricimab in the Treatment of Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema: A Review" @default.
- W4293030271 cites W1693988505 @default.
- W4293030271 cites W1836811186 @default.
- W4293030271 cites W1968189763 @default.
- W4293030271 cites W1970614272 @default.
- W4293030271 cites W1973953770 @default.
- W4293030271 cites W1981427921 @default.
- W4293030271 cites W1983943345 @default.
- W4293030271 cites W19857607 @default.
- W4293030271 cites W1991311930 @default.
- W4293030271 cites W1996571556 @default.
- W4293030271 cites W1996870435 @default.
- W4293030271 cites W2000757618 @default.
- W4293030271 cites W2004117352 @default.
- W4293030271 cites W2022878833 @default.
- W4293030271 cites W2026490523 @default.
- W4293030271 cites W2029406931 @default.
- W4293030271 cites W2029761910 @default.
- W4293030271 cites W2030729823 @default.
- W4293030271 cites W2033508973 @default.
- W4293030271 cites W2036984054 @default.
- W4293030271 cites W2051869883 @default.
- W4293030271 cites W2061182836 @default.
- W4293030271 cites W2067626374 @default.
- W4293030271 cites W2079713841 @default.
- W4293030271 cites W2081243348 @default.
- W4293030271 cites W2091906459 @default.
- W4293030271 cites W2100423457 @default.
- W4293030271 cites W2102463203 @default.
- W4293030271 cites W2109751424 @default.
- W4293030271 cites W2127203013 @default.
- W4293030271 cites W2128154767 @default.
- W4293030271 cites W2138787512 @default.
- W4293030271 cites W2148994564 @default.
- W4293030271 cites W2154711032 @default.
- W4293030271 cites W2156799887 @default.
- W4293030271 cites W2160226180 @default.
- W4293030271 cites W2160870679 @default.
- W4293030271 cites W2164724870 @default.
- W4293030271 cites W2169250157 @default.
- W4293030271 cites W2176476431 @default.
- W4293030271 cites W2280898237 @default.
- W4293030271 cites W2313838053 @default.
- W4293030271 cites W2325753945 @default.
- W4293030271 cites W2409181047 @default.
- W4293030271 cites W2414094623 @default.
- W4293030271 cites W2418164887 @default.
- W4293030271 cites W2493003848 @default.
- W4293030271 cites W2531065411 @default.
- W4293030271 cites W2552818781 @default.
- W4293030271 cites W2601396686 @default.
- W4293030271 cites W2606133995 @default.
- W4293030271 cites W2618325173 @default.
- W4293030271 cites W2622276884 @default.
- W4293030271 cites W2737102054 @default.
- W4293030271 cites W2739373612 @default.
- W4293030271 cites W2802868810 @default.
- W4293030271 cites W2809489644 @default.
- W4293030271 cites W2896203330 @default.
- W4293030271 cites W2900925102 @default.
- W4293030271 cites W2901751092 @default.
- W4293030271 cites W2909025572 @default.
- W4293030271 cites W2913311753 @default.
- W4293030271 cites W2916516108 @default.
- W4293030271 cites W2924771381 @default.
- W4293030271 cites W2943087164 @default.
- W4293030271 cites W2973134420 @default.
- W4293030271 cites W2973365668 @default.
- W4293030271 cites W2973705051 @default.
- W4293030271 cites W2974604782 @default.
- W4293030271 cites W2975999340 @default.
- W4293030271 cites W2980512479 @default.
- W4293030271 cites W2988706549 @default.
- W4293030271 cites W2996071128 @default.
- W4293030271 cites W3015569704 @default.
- W4293030271 cites W3046457241 @default.
- W4293030271 cites W3046726202 @default.
- W4293030271 cites W3047624827 @default.
- W4293030271 cites W3093321395 @default.
- W4293030271 cites W3095930907 @default.
- W4293030271 cites W3104598671 @default.
- W4293030271 cites W3121972677 @default.
- W4293030271 cites W3122249516 @default.
- W4293030271 cites W3127111365 @default.
- W4293030271 cites W3161004646 @default.
- W4293030271 cites W3165031219 @default.
- W4293030271 cites W3165134660 @default.
- W4293030271 cites W3171624526 @default.
- W4293030271 cites W3173934490 @default.
- W4293030271 cites W3178002518 @default.
- W4293030271 cites W3180085485 @default.