Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293038799> ?p ?o ?g. }
- W4293038799 endingPage "101635" @default.
- W4293038799 startingPage "101635" @default.
- W4293038799 abstract "Focal cortical dysplasias (FCDs) are the most common cause of treatment-resistant epilepsy affecting the pediatric population. Most individuals with FCD have seizure onset within the first five years of life and the majority will develop epilepsy by the age of sixteen. Many cases of FCD are postulated to be the result of abnormal brain development in utero by germline or somatic gene mutations regulating neuronal growth and migration during corticogenesis. Other cases of FCD are thought to be related to infections during brain development, with other causes still not fully determined. Typical anti-seizure medications are oftentimes ineffective in FCD. In addition, surgical intervention is often unable to be successfully performed due to the involvement of eloquent areas of the brain or insufficient resection of the epileptogenic focus, posing a challenge for physicians. The genetic nature of FCDs provides an avenue for drug development with several genetic and molecular targets undergoing study over the last two decades, with the most widely studied target being mammalian target of rapamycin (mTOR). However, other molecular targets of FCD have been identified and provide a rich field of opportunity to expand current understanding and subsequentlydesign targeted molecular therapy to improve the lives of patients with FCDs. To better inform this area of ongoing research, we performed a narrative review of the molecular markers and potential therapeutic drugs for FCDs." @default.
- W4293038799 created "2022-08-25" @default.
- W4293038799 creator A5003039381 @default.
- W4293038799 creator A5003921537 @default.
- W4293038799 creator A5006153098 @default.
- W4293038799 creator A5018811288 @default.
- W4293038799 creator A5022524088 @default.
- W4293038799 creator A5025030707 @default.
- W4293038799 creator A5041093840 @default.
- W4293038799 creator A5048709528 @default.
- W4293038799 creator A5053360172 @default.
- W4293038799 creator A5054497006 @default.
- W4293038799 creator A5074835676 @default.
- W4293038799 date "2022-12-01" @default.
- W4293038799 modified "2023-10-15" @default.
- W4293038799 title "Focal cortical dysplasia as a cause of epilepsy: The current evidence of associated genes and future therapeutic treatments" @default.
- W4293038799 cites W133872609 @default.
- W4293038799 cites W1483653355 @default.
- W4293038799 cites W1548531944 @default.
- W4293038799 cites W1704190049 @default.
- W4293038799 cites W1894713270 @default.
- W4293038799 cites W1939528805 @default.
- W4293038799 cites W1968259409 @default.
- W4293038799 cites W1969085791 @default.
- W4293038799 cites W1969554336 @default.
- W4293038799 cites W1998171204 @default.
- W4293038799 cites W2008659068 @default.
- W4293038799 cites W2021196201 @default.
- W4293038799 cites W2035268776 @default.
- W4293038799 cites W2035495486 @default.
- W4293038799 cites W2044955720 @default.
- W4293038799 cites W2058433756 @default.
- W4293038799 cites W2059707668 @default.
- W4293038799 cites W2066522177 @default.
- W4293038799 cites W2068390139 @default.
- W4293038799 cites W2084459267 @default.
- W4293038799 cites W2094147302 @default.
- W4293038799 cites W2094539571 @default.
- W4293038799 cites W2097625706 @default.
- W4293038799 cites W2099747794 @default.
- W4293038799 cites W2105727230 @default.
- W4293038799 cites W2119856985 @default.
- W4293038799 cites W2127801604 @default.
- W4293038799 cites W2129393918 @default.
- W4293038799 cites W2164826250 @default.
- W4293038799 cites W2164890061 @default.
- W4293038799 cites W2164930173 @default.
- W4293038799 cites W2268666612 @default.
- W4293038799 cites W2329321343 @default.
- W4293038799 cites W2347029403 @default.
- W4293038799 cites W2413290533 @default.
- W4293038799 cites W2542664757 @default.
- W4293038799 cites W2553184579 @default.
- W4293038799 cites W2579298745 @default.
- W4293038799 cites W2582025421 @default.
- W4293038799 cites W2588142332 @default.
- W4293038799 cites W2606262357 @default.
- W4293038799 cites W2766827112 @default.
- W4293038799 cites W2777756804 @default.
- W4293038799 cites W2779833283 @default.
- W4293038799 cites W2790570242 @default.
- W4293038799 cites W2791322140 @default.
- W4293038799 cites W2796081888 @default.
- W4293038799 cites W2801607485 @default.
- W4293038799 cites W2802211669 @default.
- W4293038799 cites W2905663987 @default.
- W4293038799 cites W2944157527 @default.
- W4293038799 cites W2966760373 @default.
- W4293038799 cites W2969667716 @default.
- W4293038799 cites W2980725598 @default.
- W4293038799 cites W3007821824 @default.
- W4293038799 cites W3103090997 @default.
- W4293038799 cites W3157829993 @default.
- W4293038799 cites W3202734787 @default.
- W4293038799 cites W4280564909 @default.
- W4293038799 doi "https://doi.org/10.1016/j.inat.2022.101635" @default.
- W4293038799 hasPublicationYear "2022" @default.
- W4293038799 type Work @default.
- W4293038799 citedByCount "2" @default.
- W4293038799 countsByYear W42930387992023 @default.
- W4293038799 crossrefType "journal-article" @default.
- W4293038799 hasAuthorship W4293038799A5003039381 @default.
- W4293038799 hasAuthorship W4293038799A5003921537 @default.
- W4293038799 hasAuthorship W4293038799A5006153098 @default.
- W4293038799 hasAuthorship W4293038799A5018811288 @default.
- W4293038799 hasAuthorship W4293038799A5022524088 @default.
- W4293038799 hasAuthorship W4293038799A5025030707 @default.
- W4293038799 hasAuthorship W4293038799A5041093840 @default.
- W4293038799 hasAuthorship W4293038799A5048709528 @default.
- W4293038799 hasAuthorship W4293038799A5053360172 @default.
- W4293038799 hasAuthorship W4293038799A5054497006 @default.
- W4293038799 hasAuthorship W4293038799A5074835676 @default.
- W4293038799 hasBestOaLocation W42930387993 @default.
- W4293038799 hasConcept C104317684 @default.
- W4293038799 hasConcept C108619961 @default.
- W4293038799 hasConcept C118552586 @default.
- W4293038799 hasConcept C145103041 @default.
- W4293038799 hasConcept C169760540 @default.