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- W4293060724 abstract "Abstract Background: Cancer cells' stem cell capabilities are thought to have a role in the beginning and development of pancreatic ductal adenocarcinoma (PDAC). The Wnt/β -catenin signalling pathway is an important regulator of cancer cell stemness. Methods: In this article, through a small range of genetic screening, we found GATA Binding Protein 6 (GATA6), It belongs to a family of transcription factors that attach to the (A/T)GATA(A/G) consensus pattern to stimulate or repress gene expression. It was discovered to be overexpressed in certain PDAC patients with a good prognosis. The biological activities of GATA6 in pancreatic cancer, however, are unknown. In current investigations, we used western blotting assays, qPCR assays, Dual-luciferase reporter assays and Chromatin immunoprecipitation assays in combination with various cytological experiments to explore the molecular mechanisms involved. Results: Overexpression of GATA6 suppresses pancreatic cancer cell development both in vitro & in vivo by affecting stemness & downregulating the expression of stemness-related markers CD133, ALDH, CD44, & SOX-9, according to the findings. GATA6 upregulates the expression of stemness-related genes by inhibiting Wnt/β-catenin signalling & suppressing β-catenin nuclear translocation. Conclusion: GATA6 inhibits the stemness features of PDAC cells via the Wnt/β-catenin signalling pathway, according to this study. As a result, it might be a viable therapeutic target for cancer therapy." @default.
- W4293060724 created "2022-08-25" @default.
- W4293060724 creator A5052237442 @default.
- W4293060724 creator A5076073719 @default.
- W4293060724 date "2022-06-29" @default.
- W4293060724 modified "2023-10-16" @default.
- W4293060724 title "GATA6 impairs pancreatic cancer cells stemness by modulating Wnt/β-catenin signaling" @default.
- W4293060724 doi "https://doi.org/10.21203/rs.3.rs-1772791/v1" @default.
- W4293060724 hasPublicationYear "2022" @default.
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