FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293066073> ?p ?o ?g. }

• W4293066073 endingPage "115211" @default.
• W4293066073 startingPage "115211" @default.
• W4293066073 abstract "Western diet (WD), high in sugar and fat, promotes obesity and associated chronic low-grade pro-inflammatory environment, leading to impaired immune function, reprogramming of innate and adaptive immune cells, and development of chronic degenerative diseases, including cardiovascular disease. Increased concentrations of circulating and tissue ceramides contribute to inflammation and cellular dysfunction common in immune metabolic and cardiometabolic disease. Therefore, ceramide-lowering interventions have been considered as strategies to improve adipose tissue health. Here, we report the ability of omega-3 polyunsaturated fatty acids (n-3PUFA) to attenuate inflammatory phenotypes promoted by WD, through ceramide-dependent pathways. Using an animal model, we show that enrichment of WD diet with n-3PUFA, reduced the expression of ceramide synthase 2 (CerS2), and lowered the concentration of long-chain ceramides (C23-C26) in plasma and adipose tissues. N-3PUFA also increased prevalence of the anti-inflammatory CD4+Foxp3+ and CD4+Foxp3+CD25+ Treg subtypes in lymphoid organs. The CerS inhibitor FTY720 mirrored the effect of n-3PUFA. Treatment of animal and human T cells with ceramide C24 in vitro, reduced CD4+Foxp3+ Treg polarisation and IL-10 production, and increased IL-17, while it decreased Erk and Akt phosphorylation downstream of T cell antigen receptors (TCR). These findings suggest that molecular mechanisms mediating the adverse effect of ceramides on regulatory T lymphocytes, progress through reduced TCR signalling. Our findings suggest that nutritional enrichment of WD with fish oil n-3PUFA can partially mitigate its detrimental effects, potentially improving the low-grade inflammation associated with immune metabolic disease. Compared to pharmacological interventions, n-3PUFA offer a simpler approach that can be accommodated as lifestyle choice." @default.
• W4293066073 created "2022-08-26" @default.
• W4293066073 creator A5005286924 @default.
• W4293066073 creator A5017745884 @default.
• W4293066073 creator A5037386450 @default.
• W4293066073 creator A5049174055 @default.
• W4293066073 creator A5055750185 @default.
• W4293066073 creator A5059268177 @default.
• W4293066073 creator A5061100202 @default.
• W4293066073 creator A5074658559 @default.
• W4293066073 creator A5085486910 @default.
• W4293066073 date "2022-10-01" @default.
• W4293066073 modified "2023-10-18" @default.
• W4293066073 title "Omega-3 polyunsaturated fatty acids reverse the impact of western diets on regulatory T cell responses through averting ceramide-mediated pathways" @default.
• W4293066073 cites W1807395491 @default.
• W4293066073 cites W1964667115 @default.
• W4293066073 cites W1991229004 @default.
• W4293066073 cites W1992633379 @default.
• W4293066073 cites W1995126002 @default.
• W4293066073 cites W1996050364 @default.
• W4293066073 cites W2034385545 @default.
• W4293066073 cites W2041254182 @default.
• W4293066073 cites W2048034267 @default.
• W4293066073 cites W2050324752 @default.
• W4293066073 cites W2066892631 @default.
• W4293066073 cites W2068514754 @default.
• W4293066073 cites W2071127617 @default.
• W4293066073 cites W2082387724 @default.
• W4293066073 cites W2086410640 @default.
• W4293066073 cites W2099540110 @default.
• W4293066073 cites W2104540250 @default.
• W4293066073 cites W2126594622 @default.
• W4293066073 cites W2159423422 @default.
• W4293066073 cites W2196263649 @default.
• W4293066073 cites W2239663419 @default.
• W4293066073 cites W2254934739 @default.
• W4293066073 cites W2332517313 @default.
• W4293066073 cites W2586506766 @default.
• W4293066073 cites W2601525990 @default.
• W4293066073 cites W2768617092 @default.
• W4293066073 cites W2777469091 @default.
• W4293066073 cites W2800478653 @default.
• W4293066073 cites W2884429253 @default.
• W4293066073 cites W2885871437 @default.
• W4293066073 cites W2908494188 @default.
• W4293066073 cites W2979902447 @default.
• W4293066073 cites W2991099207 @default.
• W4293066073 cites W2997752058 @default.
• W4293066073 cites W3008009973 @default.
• W4293066073 cites W3036087803 @default.
• W4293066073 cites W3049659910 @default.
• W4293066073 cites W3088459900 @default.
• W4293066073 cites W3095580505 @default.
• W4293066073 cites W3096830064 @default.
• W4293066073 cites W3120909848 @default.
• W4293066073 cites W3129536170 @default.
• W4293066073 cites W3133931637 @default.
• W4293066073 cites W3135536140 @default.
• W4293066073 cites W3153394236 @default.
• W4293066073 cites W3161982197 @default.
• W4293066073 cites W3181180049 @default.
• W4293066073 cites W3198668715 @default.
• W4293066073 cites W3201681642 @default.
• W4293066073 cites W3202078153 @default.
• W4293066073 cites W3214329251 @default.
• W4293066073 cites W4210582716 @default.
• W4293066073 cites W4213340657 @default.
• W4293066073 cites W4213454227 @default.
• W4293066073 cites W4220999033 @default.
• W4293066073 cites W4242539867 @default.
• W4293066073 cites W813983228 @default.
• W4293066073 doi "https://doi.org/10.1016/j.bcp.2022.115211" @default.
• W4293066073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35985403" @default.
• W4293066073 hasPublicationYear "2022" @default.
• W4293066073 type Work @default.
• W4293066073 citedByCount "3" @default.
• W4293066073 countsByYear W42930660732023 @default.
• W4293066073 crossrefType "journal-article" @default.
• W4293066073 hasAuthorship W4293066073A5005286924 @default.
• W4293066073 hasAuthorship W4293066073A5017745884 @default.
• W4293066073 hasAuthorship W4293066073A5037386450 @default.
• W4293066073 hasAuthorship W4293066073A5049174055 @default.
• W4293066073 hasAuthorship W4293066073A5055750185 @default.
• W4293066073 hasAuthorship W4293066073A5059268177 @default.
• W4293066073 hasAuthorship W4293066073A5061100202 @default.
• W4293066073 hasAuthorship W4293066073A5074658559 @default.
• W4293066073 hasAuthorship W4293066073A5085486910 @default.
• W4293066073 hasBestOaLocation W42930660731 @default.
• W4293066073 hasConcept C126322002 @default.
• W4293066073 hasConcept C134018914 @default.
• W4293066073 hasConcept C171089720 @default.
• W4293066073 hasConcept C180899940 @default.
• W4293066073 hasConcept C190283241 @default.
• W4293066073 hasConcept C19038510 @default.
• W4293066073 hasConcept C203014093 @default.
• W4293066073 hasConcept C2776090121 @default.
• W4293066073 hasConcept C2776914184 @default.
• W4293066073 hasConcept C2777851122 @default.

• next