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- W4293071197 endingPage "106661" @default.
- W4293071197 startingPage "106661" @default.
- W4293071197 abstract "Visceral leishmaniasis or Kala-azar is a vector-borne disease caused by an intracellular parasite of the genus leishmania. In India, Amphotericin B (AmB) is a first-line medication for treating leishmaniasis. After a large-scale resistance to pentavalent antimony therapy developed in Bihar state, it was rediscovered as an effective treatment for Leishmania donovani infection. AmB which binds to the ergosterol of protozoan cells causes a change in membrane integrity resulting in ions leakage, and ultimately leading to cell death. The treatment effect of liposomal AmB can be seen more quickly than deoxycholate AmB because, it has some toxic effects, but liposomal AmB is significantly less toxic. Evidence from studies suggested that ABLC (Abelcet) and ABCD (Amphotec) are as effective as l-AmB but Liposomal form (Ambisome) is a more widely accepted treatment option than conventional ones. Nevertheless, the world needs some way more efficient antileishmanial drugs that are less toxic and less expensive for people living with parasitic infections caused by Leishmania. So, academics, researchers, and sponsors need to focus on finding such drugs. This review provides a summary of the chemical, pharmacokinetic, drug-target interactions, stability, dose efficacy, and many other characteristics of the AmB and their various formulations. We have also highlighted the clinically significant aspects of PKDL and VL co-infection with HIV/TB." @default.
- W4293071197 created "2022-08-26" @default.
- W4293071197 creator A5012744982 @default.
- W4293071197 creator A5014965845 @default.
- W4293071197 creator A5019444392 @default.
- W4293071197 creator A5026482953 @default.
- W4293071197 creator A5060251393 @default.
- W4293071197 creator A5060333127 @default.
- W4293071197 date "2022-11-01" @default.
- W4293071197 modified "2023-09-29" @default.
- W4293071197 title "Amphotericin B: A drug of choice for Visceral Leishmaniasis" @default.
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