Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293081942> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4293081942 endingPage "260" @default.
- W4293081942 startingPage "253" @default.
- W4293081942 abstract "Objective: In a chromatographic cycle, the adsorption process is a critical unit operation that has a significant impact on downstream processes and, ultimately, the quality of the final products. The development of a rapid method to determine the endpoints of adsorption processes in a large-scale manufacturing is of substantial importance for herbal medicine (HM) manufacturers. Methods: In this study, the adsorption of saponins on a macroporous resin column chromatograph, a critical unit operation in Panax notoginseng (Burkill) F.H.Chen injection manufacturing, was considered as an example. The evaluation results of in-line ultraviolet and visible spectra combined with various multivariate analysis methods, including the moving block standard deviation (MBSD), difference between the moving block average and the target spectrum (DMBA-TS), soft-independent modeling of class analogy (SIMCA), and partial least-squares discriminant analysis (PLS-DA), were compared. Results: MBSD was unsuitable for adsorption processes. The relative standard errors of prediction between the predicted and experimental endpoints were 13.2%, 4.67%, and 5.71% using DMBA-TS, SIMCA, and PLS-DA, respectively. Conclusions: Among the considered analysis methods, SIMCA and PLS-DA were more effective for endpoint determination. The results of this study provide a more comprehensive overview of the effectiveness of various multivariate analysis methods to facilitate the selection of the most suitable method. This study was also conducive to address the issues of the in-line detection of adsorption endpoints to guide practical HM manufacturing. Graphical abstract: http://links.lww.com/AHM/A23" @default.
- W4293081942 created "2022-08-26" @default.
- W4293081942 creator A5006503848 @default.
- W4293081942 creator A5080652074 @default.
- W4293081942 date "2022-08-22" @default.
- W4293081942 modified "2023-10-14" @default.
- W4293081942 title "In-line spectroscopy combined with multivariate analysis methods for endpoint determination in column chromatographic adsorption processes for herbal medicine" @default.
- W4293081942 cites W1605136424 @default.
- W4293081942 cites W1829954655 @default.
- W4293081942 cites W1978262380 @default.
- W4293081942 cites W1985830194 @default.
- W4293081942 cites W2012410852 @default.
- W4293081942 cites W2012896260 @default.
- W4293081942 cites W2016319585 @default.
- W4293081942 cites W2028440296 @default.
- W4293081942 cites W2053486228 @default.
- W4293081942 cites W2063145959 @default.
- W4293081942 cites W2079775628 @default.
- W4293081942 cites W2080588640 @default.
- W4293081942 cites W2083188733 @default.
- W4293081942 cites W2089468765 @default.
- W4293081942 cites W2089884272 @default.
- W4293081942 cites W2091340910 @default.
- W4293081942 cites W2102449451 @default.
- W4293081942 cites W2118235454 @default.
- W4293081942 cites W2405032563 @default.
- W4293081942 cites W2534383270 @default.
- W4293081942 cites W2559120492 @default.
- W4293081942 cites W3004968439 @default.
- W4293081942 cites W3082305506 @default.
- W4293081942 cites W3096263378 @default.
- W4293081942 cites W3098734001 @default.
- W4293081942 cites W3111543892 @default.
- W4293081942 cites W3118473084 @default.
- W4293081942 doi "https://doi.org/10.1097/hm9.0000000000000035" @default.
- W4293081942 hasPublicationYear "2022" @default.
- W4293081942 type Work @default.
- W4293081942 citedByCount "2" @default.
- W4293081942 countsByYear W42930819422023 @default.
- W4293081942 crossrefType "journal-article" @default.
- W4293081942 hasAuthorship W4293081942A5006503848 @default.
- W4293081942 hasAuthorship W4293081942A5080652074 @default.
- W4293081942 hasBestOaLocation W42930819421 @default.
- W4293081942 hasConcept C105795698 @default.
- W4293081942 hasConcept C150394285 @default.
- W4293081942 hasConcept C161584116 @default.
- W4293081942 hasConcept C178790620 @default.
- W4293081942 hasConcept C185592680 @default.
- W4293081942 hasConcept C22354355 @default.
- W4293081942 hasConcept C33923547 @default.
- W4293081942 hasConcept C43617362 @default.
- W4293081942 hasConceptScore W4293081942C105795698 @default.
- W4293081942 hasConceptScore W4293081942C150394285 @default.
- W4293081942 hasConceptScore W4293081942C161584116 @default.
- W4293081942 hasConceptScore W4293081942C178790620 @default.
- W4293081942 hasConceptScore W4293081942C185592680 @default.
- W4293081942 hasConceptScore W4293081942C22354355 @default.
- W4293081942 hasConceptScore W4293081942C33923547 @default.
- W4293081942 hasConceptScore W4293081942C43617362 @default.
- W4293081942 hasIssue "4" @default.
- W4293081942 hasLocation W42930819421 @default.
- W4293081942 hasLocation W42930819422 @default.
- W4293081942 hasOpenAccess W4293081942 @default.
- W4293081942 hasPrimaryLocation W42930819421 @default.
- W4293081942 hasRelatedWork W1830627004 @default.
- W4293081942 hasRelatedWork W1973269398 @default.
- W4293081942 hasRelatedWork W1997546438 @default.
- W4293081942 hasRelatedWork W2022426482 @default.
- W4293081942 hasRelatedWork W2024801457 @default.
- W4293081942 hasRelatedWork W2038817326 @default.
- W4293081942 hasRelatedWork W2069325908 @default.
- W4293081942 hasRelatedWork W2169885886 @default.
- W4293081942 hasRelatedWork W2361916370 @default.
- W4293081942 hasRelatedWork W2566861829 @default.
- W4293081942 hasVolume "2" @default.
- W4293081942 isParatext "false" @default.
- W4293081942 isRetracted "false" @default.
- W4293081942 workType "article" @default.