FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293088660> ?p ?o ?g. }

• W4293088660 abstract "Entamoeba histolytica (E. histolytica) is an anaerobic parasite that causes Amoebiasis in the intestine or extraintestinal, with immunology, genetics, and environmental variables all playing a part in the disease's development, but its molecular mechanism is unknown. One of the primary obstacles in understanding the etiology of Amoebiasis will be identifying the genetics profiling that controls the Amoebiasis network. By examining the gene expression profile of Amoebiasis and comparing it with healthy controls, we could identify differentially expressed genes (DEGs). DEGs were used to build the Amoebiasis protein interaction network and calculated its network topological properties. We discovered nine key hub genes (KHGs): JUN, PTGS2, FCGR3A, MNDA, CYBB, EGR1, CCL2, TLR8, and LRRK2 genes. The genes JUN and EGR1 were transcriptional factors (TFs) and up-regulated, others down-regulated. hsa-miR-155-5p, hsa-miR-101-3p, hsa-miR-124-3p, hsa-miR-26b-5p, and hsa-miR-16-5p are also among the essential miRNAs that have been demonstrated to be targeted by KHGs. These KHGs were primarily enriched in the IL-17 signaling pathway, TNF signaling pathway, NOD-like receptor signaling pathway, and Toll-like receptor signaling pathway. miRNAs were grouped in various pathways, focusing on the TGF-β signaling pathway, human immunodeficiency virus 1 infection, insulin signaling pathway, signaling pathways regulating pluripotency of stem cells, etc. Amoebiasis KHGs (JUN, PTGS2, CCL2, and MNDA) and their associated miRNAs are the primary targets for therapeutic methods and possible biomarkers. Furthermore, we identified drugs for genes JUN, PTGS2, FCGR3A, CCL2, and LRRK2. KHGs, on the other hand, required experimental validation to prove their efficacy." @default.
• W4293088660 created "2022-08-26" @default.
• W4293088660 creator A5057137716 @default.
• W4293088660 creator A5058384780 @default.
• W4293088660 creator A5078315190 @default.
• W4293088660 creator A5079746535 @default.
• W4293088660 creator A5088751855 @default.
• W4293088660 date "2022-10-01" @default.
• W4293088660 modified "2023-10-14" @default.
• W4293088660 title "Entamoeba histolytica HM-1: IMSS gene expression profiling identifies key hub genes, potential biomarkers, and pathways in Amoebiasis infection: a systematic network meta-analysis" @default.
• W4293088660 cites W1966402834 @default.
• W4293088660 cites W1968830433 @default.
• W4293088660 cites W1969824500 @default.
• W4293088660 cites W1979858376 @default.
• W4293088660 cites W1982925953 @default.
• W4293088660 cites W1983131031 @default.
• W4293088660 cites W2006738360 @default.
• W4293088660 cites W2007597725 @default.
• W4293088660 cites W2014503546 @default.
• W4293088660 cites W2016432437 @default.
• W4293088660 cites W2024375726 @default.
• W4293088660 cites W2035005770 @default.
• W4293088660 cites W2062267695 @default.
• W4293088660 cites W2067299927 @default.
• W4293088660 cites W2069007188 @default.
• W4293088660 cites W2074433251 @default.
• W4293088660 cites W2075223145 @default.
• W4293088660 cites W2075804353 @default.
• W4293088660 cites W2087118469 @default.
• W4293088660 cites W2089923844 @default.
• W4293088660 cites W2095213694 @default.
• W4293088660 cites W2097908478 @default.
• W4293088660 cites W2102375472 @default.
• W4293088660 cites W2104824886 @default.
• W4293088660 cites W2106608030 @default.
• W4293088660 cites W2109225342 @default.
• W4293088660 cites W2109543073 @default.
• W4293088660 cites W2110065044 @default.
• W4293088660 cites W2113878188 @default.
• W4293088660 cites W2116634113 @default.
• W4293088660 cites W2124954099 @default.
• W4293088660 cites W2134730661 @default.
• W4293088660 cites W2136847875 @default.
• W4293088660 cites W2144526849 @default.
• W4293088660 cites W2146512944 @default.
• W4293088660 cites W2149026447 @default.
• W4293088660 cites W2158217645 @default.
• W4293088660 cites W2159675211 @default.
• W4293088660 cites W2160886349 @default.
• W4293088660 cites W2161738112 @default.
• W4293088660 cites W2162465757 @default.
• W4293088660 cites W2166301662 @default.
• W4293088660 cites W2170291048 @default.
• W4293088660 cites W2206568619 @default.
• W4293088660 cites W2243075419 @default.
• W4293088660 cites W2289023840 @default.
• W4293088660 cites W2311370038 @default.
• W4293088660 cites W2316505461 @default.
• W4293088660 cites W2325011840 @default.
• W4293088660 cites W2419539547 @default.
• W4293088660 cites W2552231036 @default.
• W4293088660 cites W2558742480 @default.
• W4293088660 cites W2575368573 @default.
• W4293088660 cites W2768016303 @default.
• W4293088660 cites W2772870108 @default.
• W4293088660 cites W2782454362 @default.
• W4293088660 cites W2802480364 @default.
• W4293088660 cites W2900569176 @default.
• W4293088660 cites W2903032927 @default.
• W4293088660 cites W2916567288 @default.
• W4293088660 cites W2951254340 @default.
• W4293088660 cites W2967927701 @default.
• W4293088660 cites W2974697447 @default.
• W4293088660 cites W2975808274 @default.
• W4293088660 cites W2985896705 @default.
• W4293088660 cites W2987179243 @default.
• W4293088660 cites W2990368503 @default.
• W4293088660 cites W3000049308 @default.
• W4293088660 cites W3012030421 @default.
• W4293088660 cites W3107626709 @default.
• W4293088660 cites W3148907786 @default.
• W4293088660 cites W3200900997 @default.
• W4293088660 cites W3217336457 @default.
• W4293088660 cites W4210976667 @default.
• W4293088660 cites W4211257403 @default.
• W4293088660 cites W4220686562 @default.
• W4293088660 cites W4223484815 @default.
• W4293088660 cites W4237038612 @default.
• W4293088660 cites W4254687493 @default.
• W4293088660 doi "https://doi.org/10.1042/bsr20220191" @default.
• W4293088660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36004808" @default.
• W4293088660 hasPublicationYear "2022" @default.
• W4293088660 type Work @default.
• W4293088660 citedByCount "4" @default.
• W4293088660 countsByYear W42930886602022 @default.
• W4293088660 countsByYear W42930886602023 @default.
• W4293088660 crossrefType "journal-article" @default.
• W4293088660 hasAuthorship W4293088660A5057137716 @default.
• W4293088660 hasAuthorship W4293088660A5058384780 @default.
• W4293088660 hasAuthorship W4293088660A5078315190 @default.

• next