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- W4293093398 abstract "ABSTRACT Recent advances in the human microbiome characterization have revealed significant oral microbial detection in stools of dysbiotic patients. However, little is known about the potential interactions of these invasive oral microorganisms with commensal intestinal microbiota and host. In this proof of concept study, we propose a new model of oral to gut invasion by the combined use of an in vitro model simulating both the physicochemical and microbial (lumen and mucus-associated microbes) parameters of the human colon (M-ARCOL), a salivary enrichment protocol and whole metagenome shotgun sequencing. Oral invasion of the intestinal microbiota was simulated by injection of enriched saliva in the in vitro colon model inoculated with faecal sample from the same healthy adult donor. The mucosal compartment of M-ARCOL was able to retain the highest species richness levels over time, whilst it decreased in the luminal compartment. This study also showed that oral microorganisms preferably colonized the mucosal microenvironment, suggesting potential oral-to-intestinal mucosal competitions. This new model of oral-to-gut invasion can provide useful mechanistic insights into the role of oral microbiome in various disease processes." @default.
- W4293093398 created "2022-08-26" @default.
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- W4293093398 date "2022-10-19" @default.
- W4293093398 modified "2023-10-18" @default.
- W4293093398 title "<i>In vitro</i>modelling of oral microbial invasion in the human colon" @default.
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- W4293093398 doi "https://doi.org/10.1101/2022.10.17.512642" @default.
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