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- W4293096198 abstract "We have read with great interest the article by Aujla et al. 1 Aujla S. Aloe C. Vannitamby A. et al. PD-L1 copy number loss in NSCLC associates with reduced PD-L1 tumor staining and a cold immunophenotype. J Thorac Oncol. 2022; 17: 675-687 Abstract Full Text Full Text PDF PubMed Scopus (6) Google Scholar In this research, they found a high positive association between programmed death-ligand 1 (PD-L1) copy number variants (CNV) and expression in lung cancer samples and concluded that the PD-L1 CNV could be exploited as a biomarker for immunotherapy. Indeed, as the authors mentioned, the PD-L1 CNV detection requires fewer biopsy specimens than immunohistochemistry. Another superiority is that the spatial heterogeneity of PD-L1 CNV in different tumor sites (the primary tumor or surrounding lymph nodes) is very low. Therefore, the authors suggested that measurement of PD-L1 CNV may be superior to immunohistochemistry, the currently accepted standard method. Response to “Non-Tumor Cells in Tumor Specimens Impair the Accuracy of qPCR in the Detection of PD-L1 CNV and mRNA Expression”Journal of Thoracic OncologyVol. 17Issue 9PreviewWe appreciate the comments from Zhang et al. regarding our recently published article entitled “Programmed Death-Ligand 1 Copy Number Loss in NSCLC Associates With Reduced Programmed Death-Ligand 1 Tumor Staining and a Cold Immunophenotype.” In our study, tumor tissue obtained from patients with NSCLC undergoing resection surgery was macrodissected to enrich for tumorous material, with a minimum of at least 50% tumor content confirmed by a pathologist. We then used the snap-frozen tumor biopsies to determine the programmed death-ligand 1 (PD-L1) copy number levels by quantitative polymerase chain reaction, in which we found that tumors with a low PD-L1 copy number display reduced PD-L1 mRNA expression, reduced PD-L1 tumor cell staining, and an immunologic cold phenotype. Full-Text PDF" @default.
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- W4293096198 date "2022-09-01" @default.
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- W4293096198 title "Nontumor cells in Tumor Specimens Impair the Accuracy of Quantitative Polymerase Chain Reaction in the Detection of Programmed Death-Ligand 1 Copy Number Variant and mRNA Expression" @default.
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- W4293096198 doi "https://doi.org/10.1016/j.jtho.2022.02.012" @default.
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