Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293101046> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4293101046 abstract "Abstract Background: Multi-drug delivery system based on polymer carrier is emerging for alleviating dose-limiting toxicities of first-line cytotoxic anticancer drugs such as doxorubicin (DOX) for breast cancer chemotherapy. By co-loading the premium natural antioxidant salvianolic acid A (SAA) through colloidal self-assembly of amphiphilic copolymer, we herein developed CPMSD, a complex polymeric micellar system to overcome cardiotoxicity associated with DOX. Results: Optimal formulation was obtained by DOE study and CPMSD micelles were well constructed by using mPEG-PCL for entrapment at a drug-carrier mass ratio of 1:5 and DOX-SAA mass ratio of 1:4. Molecular dynamics simulation revealed the ratiometrical co-encapsulation of SAA into the hydrophobic cavity but DOX to ball-shaped surface of micelles due to hydrophilicity. Characterization study manifested favorable biopharmaceutical properties such as small and uniform particle size, fairly high drug loading capacity, as well as good colloidal stability and controlled drug release. CPMSD maintained anticancer efficacy of DOX and the action mechanism, which did not be affected by co-administering SAA. More to the point, it was of great benefit to systemic safety and cardio-protective effect against oxidative stress injuries associated with DOX in tumor-bearing mice. Conclusions: All the findings substantiated that CPMSD would be a promising multifunctional nanosystem of DOX for breast cancer chemotherapy." @default.
- W4293101046 created "2022-08-26" @default.
- W4293101046 creator A5016686730 @default.
- W4293101046 creator A5017257054 @default.
- W4293101046 creator A5021781633 @default.
- W4293101046 creator A5027974095 @default.
- W4293101046 creator A5030980863 @default.
- W4293101046 creator A5048956159 @default.
- W4293101046 creator A5049328355 @default.
- W4293101046 creator A5059085853 @default.
- W4293101046 date "2022-03-21" @default.
- W4293101046 modified "2023-09-26" @default.
- W4293101046 title "Nanomicelles co-loaded with doxorubicin and salvianolic acid A for breast cancer chemotherapy" @default.
- W4293101046 doi "https://doi.org/10.21203/rs.3.rs-1355560/v1" @default.
- W4293101046 hasPublicationYear "2022" @default.
- W4293101046 type Work @default.
- W4293101046 citedByCount "0" @default.
- W4293101046 crossrefType "posted-content" @default.
- W4293101046 hasAuthorship W4293101046A5016686730 @default.
- W4293101046 hasAuthorship W4293101046A5017257054 @default.
- W4293101046 hasAuthorship W4293101046A5021781633 @default.
- W4293101046 hasAuthorship W4293101046A5027974095 @default.
- W4293101046 hasAuthorship W4293101046A5030980863 @default.
- W4293101046 hasAuthorship W4293101046A5048956159 @default.
- W4293101046 hasAuthorship W4293101046A5049328355 @default.
- W4293101046 hasAuthorship W4293101046A5059085853 @default.
- W4293101046 hasBestOaLocation W42931010461 @default.
- W4293101046 hasConcept C11268172 @default.
- W4293101046 hasConcept C121608353 @default.
- W4293101046 hasConcept C126322002 @default.
- W4293101046 hasConcept C171250308 @default.
- W4293101046 hasConcept C178790620 @default.
- W4293101046 hasConcept C184651966 @default.
- W4293101046 hasConcept C185592680 @default.
- W4293101046 hasConcept C192562407 @default.
- W4293101046 hasConcept C2776694085 @default.
- W4293101046 hasConcept C2779820397 @default.
- W4293101046 hasConcept C2780035454 @default.
- W4293101046 hasConcept C2781303535 @default.
- W4293101046 hasConcept C530470458 @default.
- W4293101046 hasConcept C71924100 @default.
- W4293101046 hasConcept C98274493 @default.
- W4293101046 hasConceptScore W4293101046C11268172 @default.
- W4293101046 hasConceptScore W4293101046C121608353 @default.
- W4293101046 hasConceptScore W4293101046C126322002 @default.
- W4293101046 hasConceptScore W4293101046C171250308 @default.
- W4293101046 hasConceptScore W4293101046C178790620 @default.
- W4293101046 hasConceptScore W4293101046C184651966 @default.
- W4293101046 hasConceptScore W4293101046C185592680 @default.
- W4293101046 hasConceptScore W4293101046C192562407 @default.
- W4293101046 hasConceptScore W4293101046C2776694085 @default.
- W4293101046 hasConceptScore W4293101046C2779820397 @default.
- W4293101046 hasConceptScore W4293101046C2780035454 @default.
- W4293101046 hasConceptScore W4293101046C2781303535 @default.
- W4293101046 hasConceptScore W4293101046C530470458 @default.
- W4293101046 hasConceptScore W4293101046C71924100 @default.
- W4293101046 hasConceptScore W4293101046C98274493 @default.
- W4293101046 hasLocation W42931010461 @default.
- W4293101046 hasOpenAccess W4293101046 @default.
- W4293101046 hasPrimaryLocation W42931010461 @default.
- W4293101046 hasRelatedWork W104929262 @default.
- W4293101046 hasRelatedWork W1986424473 @default.
- W4293101046 hasRelatedWork W2027137539 @default.
- W4293101046 hasRelatedWork W2364880874 @default.
- W4293101046 hasRelatedWork W2746733615 @default.
- W4293101046 hasRelatedWork W2759100261 @default.
- W4293101046 hasRelatedWork W2811236823 @default.
- W4293101046 hasRelatedWork W2891443448 @default.
- W4293101046 hasRelatedWork W3097129225 @default.
- W4293101046 hasRelatedWork W4311376300 @default.
- W4293101046 isParatext "false" @default.
- W4293101046 isRetracted "false" @default.
- W4293101046 workType "article" @default.