FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293101543> ?p ?o ?g. }

• W4293101543 abstract "Abstract We seek to demonstrate whether therapeutic efficacy can be improved by combination of repeated intravenous administration and local transplantation of human induced pluripotential stem cell derived MSCs (hiPSC-MSCs). In this study, mice model of hind-limb ischemia is established by ligation of left femoral artery. hiPSC-MSCs (5 × 10 5 ) is intravenously administrated immediately after induction of hind limb ischemia with or without following intravenous administration of hiPSC-MSCs every week or every 3 days. Intramuscular transplantation of hiPSC-MSCs (3 × 10 6 ) is performed one week after induction of hind-limb ischemia. We compare the therapeutic efficacy and cell survival of intramuscular transplantation of hiPSC-MSCs with or without a single or repeated intravenous administration of hiPSC-MSCs. Repeated intravenous administration of hiPSC-MSCs can increase splenic regulatory T cells (Tregs) activation, decrease splenic natural killer (NK) cells expression, promote the polarization of M2 macrophages in the ischemic area and improved blood perfusion in the ischemic limbs. The improved therapeutic efficacy of MSC-based therapy is due to both increased engraftment of intramuscular transplanted hiPSC-MSCs and intravenous infused hiPSC-MSCs. In conclusion, our study support a combination of repeated systemic infusion and local transplantation of hiPSC-MSCs for cardiovascular disease." @default.
• W4293101543 created "2022-08-26" @default.
• W4293101543 creator A5000501514 @default.
• W4293101543 creator A5005228021 @default.
• W4293101543 creator A5021138454 @default.
• W4293101543 creator A5022586449 @default.
• W4293101543 creator A5025616864 @default.
• W4293101543 creator A5029785454 @default.
• W4293101543 creator A5037224266 @default.
• W4293101543 creator A5063355741 @default.
• W4293101543 creator A5070183551 @default.
• W4293101543 creator A5091047233 @default.
• W4293101543 date "2022-08-25" @default.
• W4293101543 modified "2023-10-18" @default.
• W4293101543 title "Repeated intravenous administration of hiPSC-MSCs enhance the efficacy of cell-based therapy in tissue regeneration" @default.
• W4293101543 cites W1899596267 @default.
• W4293101543 cites W1987612095 @default.
• W4293101543 cites W2000912956 @default.
• W4293101543 cites W2052004719 @default.
• W4293101543 cites W2262286634 @default.
• W4293101543 cites W2268790843 @default.
• W4293101543 cites W2313158924 @default.
• W4293101543 cites W2465894853 @default.
• W4293101543 cites W2571952474 @default.
• W4293101543 cites W2724115405 @default.
• W4293101543 cites W2735275855 @default.
• W4293101543 cites W2792964988 @default.
• W4293101543 cites W2801567408 @default.
• W4293101543 cites W2808158796 @default.
• W4293101543 cites W2891892708 @default.
• W4293101543 cites W2921802289 @default.
• W4293101543 cites W2923295100 @default.
• W4293101543 cites W2940383594 @default.
• W4293101543 cites W2969042755 @default.
• W4293101543 cites W2980803080 @default.
• W4293101543 cites W2990005866 @default.
• W4293101543 cites W2999879304 @default.
• W4293101543 cites W3030645235 @default.
• W4293101543 cites W3031388738 @default.
• W4293101543 cites W3043861550 @default.
• W4293101543 cites W3089177938 @default.
• W4293101543 cites W3172324115 @default.
• W4293101543 doi "https://doi.org/10.1038/s42003-022-03833-8" @default.
• W4293101543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36008710" @default.
• W4293101543 hasPublicationYear "2022" @default.
• W4293101543 type Work @default.
• W4293101543 citedByCount "3" @default.
• W4293101543 countsByYear W42931015432022 @default.
• W4293101543 countsByYear W42931015432023 @default.
• W4293101543 crossrefType "journal-article" @default.
• W4293101543 hasAuthorship W4293101543A5000501514 @default.
• W4293101543 hasAuthorship W4293101543A5005228021 @default.
• W4293101543 hasAuthorship W4293101543A5021138454 @default.
• W4293101543 hasAuthorship W4293101543A5022586449 @default.
• W4293101543 hasAuthorship W4293101543A5025616864 @default.
• W4293101543 hasAuthorship W4293101543A5029785454 @default.
• W4293101543 hasAuthorship W4293101543A5037224266 @default.
• W4293101543 hasAuthorship W4293101543A5063355741 @default.
• W4293101543 hasAuthorship W4293101543A5070183551 @default.
• W4293101543 hasAuthorship W4293101543A5091047233 @default.
• W4293101543 hasBestOaLocation W42931015431 @default.
• W4293101543 hasConcept C126322002 @default.
• W4293101543 hasConcept C141071460 @default.
• W4293101543 hasConcept C142724271 @default.
• W4293101543 hasConcept C150903083 @default.
• W4293101543 hasConcept C164705383 @default.
• W4293101543 hasConcept C179437574 @default.
• W4293101543 hasConcept C198826908 @default.
• W4293101543 hasConcept C207001950 @default.
• W4293101543 hasConcept C25938499 @default.
• W4293101543 hasConcept C2911091166 @default.
• W4293101543 hasConcept C42219234 @default.
• W4293101543 hasConcept C51738704 @default.
• W4293101543 hasConcept C541997718 @default.
• W4293101543 hasConcept C71924100 @default.
• W4293101543 hasConcept C86803240 @default.
• W4293101543 hasConcept C98274493 @default.
• W4293101543 hasConceptScore W4293101543C126322002 @default.
• W4293101543 hasConceptScore W4293101543C141071460 @default.
• W4293101543 hasConceptScore W4293101543C142724271 @default.
• W4293101543 hasConceptScore W4293101543C150903083 @default.
• W4293101543 hasConceptScore W4293101543C164705383 @default.
• W4293101543 hasConceptScore W4293101543C179437574 @default.
• W4293101543 hasConceptScore W4293101543C198826908 @default.
• W4293101543 hasConceptScore W4293101543C207001950 @default.
• W4293101543 hasConceptScore W4293101543C25938499 @default.
• W4293101543 hasConceptScore W4293101543C2911091166 @default.
• W4293101543 hasConceptScore W4293101543C42219234 @default.
• W4293101543 hasConceptScore W4293101543C51738704 @default.
• W4293101543 hasConceptScore W4293101543C541997718 @default.
• W4293101543 hasConceptScore W4293101543C71924100 @default.
• W4293101543 hasConceptScore W4293101543C86803240 @default.
• W4293101543 hasConceptScore W4293101543C98274493 @default.
• W4293101543 hasIssue "1" @default.
• W4293101543 hasLocation W42931015431 @default.
• W4293101543 hasLocation W42931015432 @default.
• W4293101543 hasLocation W42931015433 @default.
• W4293101543 hasLocation W42931015434 @default.
• W4293101543 hasOpenAccess W4293101543 @default.
• W4293101543 hasPrimaryLocation W42931015431 @default.

• next