FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293105584> ?p ?o ?g. }

• W4293105584 endingPage "e0272835" @default.
• W4293105584 startingPage "e0272835" @default.
• W4293105584 abstract "Background Proteinuria results from kidney damage and can be a predictor of illness severity and mortality in the intensive care unit (ICU). However, the optimal timing of proteinuria measurements and the reference values remain undetermined. Our objective was to identify the patterns of proteinuria change associated with mortality in ICU patients with sepsis or shock. Methods This monocentric retrospective cohort study performed from April 2010 to April 2018 involved all ICU patients with sepsis or shock and at least two measurements of proteinuria from a 24h-urine collection during the first 10 days of ICU stay, the first of which was made within 48h after ICU admission. We identified proteinuria trajectories by a semi-parametric mixture model and analysed the association between the trajectories and the mortality at day 28 by Cox proportional-hazards model. Results A total of 3,344 measurements of proteinuria from 659 patients were analysed. Four proteinuria trajectories were identified. Trajectories 1, 2, 3 and 4 comprised 127, 421, 60 and 51 patients, and were characterized by a first proteinuria of 1.14 [0.66–1.55], 0.52 [0.26–0.91], 2.92 [2.38–3.84] and 2.58 [1.75–3.32] g/24h (p<0.001) and a mortality of 24.4%, 38%, 20% and 43% (p = 0.002), respectively. Trajectories 3 and 4 had a high first proteinuria (>2g/24h). Only, the proteinuria of trajectory 4 increased within 3 days following the first measurement and was associated with increased mortality at day 28 (hazard ratio: 2.36 95%CI [1.07–5.19], p = 0.03), regardless of acute renal failure. The factors associated with trajectory 4 were cancer (relative risk: 8.91 95%CI [2.09–38.02], p = 0.003) and use of inotropic drugs (relative risk: 0.17 95%CI [0.04–0.69], p = 0.01). Conclusion This exploratory study of ICU patients with sepsis or shock identified four proteinuria trajectories with distinct patterns of proteinuria change over time and mortality rates. These results provide novel insights into renal pathophysiology and may be helpful to investigate subphenotypes of kidney injury among ICU patients in future studies." @default.
• W4293105584 created "2022-08-26" @default.
• W4293105584 creator A5007115589 @default.
• W4293105584 creator A5010790844 @default.
• W4293105584 creator A5012986857 @default.
• W4293105584 creator A5013394355 @default.
• W4293105584 creator A5052274789 @default.
• W4293105584 creator A5060367738 @default.
• W4293105584 creator A5077019788 @default.
• W4293105584 creator A5080255683 @default.
• W4293105584 date "2022-08-24" @default.
• W4293105584 modified "2023-09-30" @default.
• W4293105584 title "Association between proteinuria trajectories and outcomes in critically ill patients with sepsis or shock" @default.
• W4293105584 cites W1499722362 @default.
• W4293105584 cites W1603503618 @default.
• W4293105584 cites W1965852591 @default.
• W4293105584 cites W1967635684 @default.
• W4293105584 cites W1970179271 @default.
• W4293105584 cites W1992451041 @default.
• W4293105584 cites W1994043844 @default.
• W4293105584 cites W2003500862 @default.
• W4293105584 cites W2017602861 @default.
• W4293105584 cites W2033958453 @default.
• W4293105584 cites W2060980473 @default.
• W4293105584 cites W2081845888 @default.
• W4293105584 cites W2083175765 @default.
• W4293105584 cites W2108451834 @default.
• W4293105584 cites W2110633224 @default.
• W4293105584 cites W2113760558 @default.
• W4293105584 cites W2133871449 @default.
• W4293105584 cites W2139791477 @default.
• W4293105584 cites W2161533677 @default.
• W4293105584 cites W2280404143 @default.
• W4293105584 cites W2427094903 @default.
• W4293105584 cites W2560560224 @default.
• W4293105584 cites W2581605534 @default.
• W4293105584 cites W3005747003 @default.
• W4293105584 cites W3133513134 @default.
• W4293105584 cites W3142804561 @default.
• W4293105584 cites W3149383690 @default.
• W4293105584 cites W3156000398 @default.
• W4293105584 cites W3177627853 @default.
• W4293105584 cites W4206671482 @default.
• W4293105584 cites W4206986507 @default.
• W4293105584 cites W4221129885 @default.
• W4293105584 cites W3129519311 @default.
• W4293105584 doi "https://doi.org/10.1371/journal.pone.0272835" @default.
• W4293105584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36001593" @default.
• W4293105584 hasPublicationYear "2022" @default.
• W4293105584 type Work @default.
• W4293105584 citedByCount "0" @default.
• W4293105584 crossrefType "journal-article" @default.
• W4293105584 hasAuthorship W4293105584A5007115589 @default.
• W4293105584 hasAuthorship W4293105584A5010790844 @default.
• W4293105584 hasAuthorship W4293105584A5012986857 @default.
• W4293105584 hasAuthorship W4293105584A5013394355 @default.
• W4293105584 hasAuthorship W4293105584A5052274789 @default.
• W4293105584 hasAuthorship W4293105584A5060367738 @default.
• W4293105584 hasAuthorship W4293105584A5077019788 @default.
• W4293105584 hasAuthorship W4293105584A5080255683 @default.
• W4293105584 hasBestOaLocation W42931055841 @default.
• W4293105584 hasConcept C126322002 @default.
• W4293105584 hasConcept C167135981 @default.
• W4293105584 hasConcept C177713679 @default.
• W4293105584 hasConcept C207103383 @default.
• W4293105584 hasConcept C2776376669 @default.
• W4293105584 hasConcept C2777628635 @default.
• W4293105584 hasConcept C2778384902 @default.
• W4293105584 hasConcept C2779561371 @default.
• W4293105584 hasConcept C2780091579 @default.
• W4293105584 hasConcept C2780472472 @default.
• W4293105584 hasConcept C2987404301 @default.
• W4293105584 hasConcept C44249647 @default.
• W4293105584 hasConcept C50382708 @default.
• W4293105584 hasConcept C71924100 @default.
• W4293105584 hasConceptScore W4293105584C126322002 @default.
• W4293105584 hasConceptScore W4293105584C167135981 @default.
• W4293105584 hasConceptScore W4293105584C177713679 @default.
• W4293105584 hasConceptScore W4293105584C207103383 @default.
• W4293105584 hasConceptScore W4293105584C2776376669 @default.
• W4293105584 hasConceptScore W4293105584C2777628635 @default.
• W4293105584 hasConceptScore W4293105584C2778384902 @default.
• W4293105584 hasConceptScore W4293105584C2779561371 @default.
• W4293105584 hasConceptScore W4293105584C2780091579 @default.
• W4293105584 hasConceptScore W4293105584C2780472472 @default.
• W4293105584 hasConceptScore W4293105584C2987404301 @default.
• W4293105584 hasConceptScore W4293105584C44249647 @default.
• W4293105584 hasConceptScore W4293105584C50382708 @default.
• W4293105584 hasConceptScore W4293105584C71924100 @default.
• W4293105584 hasIssue "8" @default.
• W4293105584 hasLocation W42931055841 @default.
• W4293105584 hasLocation W42931055842 @default.
• W4293105584 hasLocation W42931055843 @default.
• W4293105584 hasOpenAccess W4293105584 @default.
• W4293105584 hasPrimaryLocation W42931055841 @default.
• W4293105584 hasRelatedWork W1984304831 @default.
• W4293105584 hasRelatedWork W2020861620 @default.
• W4293105584 hasRelatedWork W2026094606 @default.

• next