Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293105611> ?p ?o ?g. }
- W4293105611 endingPage "103" @default.
- W4293105611 startingPage "95" @default.
- W4293105611 abstract "Limited data on the role of pharmacotherapy for patients with locally advanced, recurrent, or metastatic vulvar cancer are available.This article aims to provide an overview of the current treatment options for patients with vulvar cancer. PubMed (MEDLINE), Embase, CENTRAL, Scopus, and Web of Science databases, as well as ClinicalTrials.gov were searched to review the current evidence as well as future perspectives on the role of pharmacotherapy in patients with vulvar carcinoma.There has been no consensus on the pharmacotherapy for patients with locally advanced, recurrent, or metastatic vulvar cancer. Concurrent platinum-based chemoradiation is the most widely used treatment modality for primary treatment or for neoadjuvant settings. Chemotherapy in metastatic disease is considered a palliative treatment. Anti-EGFR tyrosine kinase inhibitors seem to show promising anti-tumor activity in patients harboring EGFR alteration. Similarly, growing evidence supports the adoption of immune checkpoint inhibitors in both neoadjuvant and metastatic settings. Molecular and genomic profiling is advocated to identify target mutations. The PI3K/AKT/mTOR and HER/ErbB pathways might represent two intriguing treatment options. Treatments directed against HPV are discussed as well. Further evidence is warranted to identify the best treatment modalities for patients with locally advanced, recurrent, and metastatic disease." @default.
- W4293105611 created "2022-08-26" @default.
- W4293105611 creator A5010330527 @default.
- W4293105611 creator A5015473918 @default.
- W4293105611 creator A5052465045 @default.
- W4293105611 creator A5056705988 @default.
- W4293105611 creator A5070572496 @default.
- W4293105611 creator A5072059804 @default.
- W4293105611 creator A5077201041 @default.
- W4293105611 creator A5080869614 @default.
- W4293105611 creator A5085902439 @default.
- W4293105611 creator A5088920406 @default.
- W4293105611 date "2022-08-30" @default.
- W4293105611 modified "2023-10-13" @default.
- W4293105611 title "An update on current pharmacotherapy for vulvar cancer" @default.
- W4293105611 cites W1573587473 @default.
- W4293105611 cites W1978163677 @default.
- W4293105611 cites W1985904941 @default.
- W4293105611 cites W1991449390 @default.
- W4293105611 cites W2008018346 @default.
- W4293105611 cites W2012330784 @default.
- W4293105611 cites W2012908535 @default.
- W4293105611 cites W2027677325 @default.
- W4293105611 cites W2034822990 @default.
- W4293105611 cites W2036167265 @default.
- W4293105611 cites W2036754281 @default.
- W4293105611 cites W2037951950 @default.
- W4293105611 cites W2049075271 @default.
- W4293105611 cites W2058347788 @default.
- W4293105611 cites W2059958002 @default.
- W4293105611 cites W2064879556 @default.
- W4293105611 cites W2074094034 @default.
- W4293105611 cites W2077053376 @default.
- W4293105611 cites W2081423951 @default.
- W4293105611 cites W2084196799 @default.
- W4293105611 cites W2093426923 @default.
- W4293105611 cites W2097196133 @default.
- W4293105611 cites W2154131697 @default.
- W4293105611 cites W2157185756 @default.
- W4293105611 cites W2283305132 @default.
- W4293105611 cites W2322003257 @default.
- W4293105611 cites W2339068436 @default.
- W4293105611 cites W2507163373 @default.
- W4293105611 cites W2566050889 @default.
- W4293105611 cites W2584313480 @default.
- W4293105611 cites W2626965670 @default.
- W4293105611 cites W2728961991 @default.
- W4293105611 cites W2944759755 @default.
- W4293105611 cites W2972043635 @default.
- W4293105611 cites W2972117663 @default.
- W4293105611 cites W3021273396 @default.
- W4293105611 cites W3080678175 @default.
- W4293105611 cites W3101789168 @default.
- W4293105611 cites W3128527220 @default.
- W4293105611 cites W3138938629 @default.
- W4293105611 cites W3177272644 @default.
- W4293105611 cites W3177401909 @default.
- W4293105611 cites W3182562445 @default.
- W4293105611 cites W3185295522 @default.
- W4293105611 cites W3200231835 @default.
- W4293105611 cites W3205339194 @default.
- W4293105611 cites W3210216620 @default.
- W4293105611 cites W4200138043 @default.
- W4293105611 cites W4200362858 @default.
- W4293105611 cites W4212784899 @default.
- W4293105611 cites W4213209058 @default.
- W4293105611 cites W4220715466 @default.
- W4293105611 cites W4221054879 @default.
- W4293105611 cites W4224265119 @default.
- W4293105611 cites W4232618296 @default.
- W4293105611 doi "https://doi.org/10.1080/14656566.2022.2117608" @default.
- W4293105611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36002936" @default.
- W4293105611 hasPublicationYear "2022" @default.
- W4293105611 type Work @default.
- W4293105611 citedByCount "1" @default.
- W4293105611 crossrefType "journal-article" @default.
- W4293105611 hasAuthorship W4293105611A5010330527 @default.
- W4293105611 hasAuthorship W4293105611A5015473918 @default.
- W4293105611 hasAuthorship W4293105611A5052465045 @default.
- W4293105611 hasAuthorship W4293105611A5056705988 @default.
- W4293105611 hasAuthorship W4293105611A5070572496 @default.
- W4293105611 hasAuthorship W4293105611A5072059804 @default.
- W4293105611 hasAuthorship W4293105611A5077201041 @default.
- W4293105611 hasAuthorship W4293105611A5080869614 @default.
- W4293105611 hasAuthorship W4293105611A5085902439 @default.
- W4293105611 hasAuthorship W4293105611A5088920406 @default.
- W4293105611 hasConcept C126322002 @default.
- W4293105611 hasConcept C143998085 @default.
- W4293105611 hasConcept C2779134260 @default.
- W4293105611 hasConcept C500440147 @default.
- W4293105611 hasConcept C60644358 @default.
- W4293105611 hasConcept C71924100 @default.
- W4293105611 hasConcept C86803240 @default.
- W4293105611 hasConceptScore W4293105611C126322002 @default.
- W4293105611 hasConceptScore W4293105611C143998085 @default.
- W4293105611 hasConceptScore W4293105611C2779134260 @default.
- W4293105611 hasConceptScore W4293105611C500440147 @default.
- W4293105611 hasConceptScore W4293105611C60644358 @default.