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- W4293111637 endingPage "189" @default.
- W4293111637 startingPage "165" @default.
- W4293111637 abstract "Contraception is one of the ways of controlling population growth; however, contraceptive methods used today are not available to many individuals due to sociological, financial, or educational limitations. Immunocontraception may provide alternative to the current contraceptive methods due to its reversibility and the fact that most of the developing countries where population growth is highest have service infrastructure for delivery of disease vaccines into which contraceptive vaccines could be incorporated. Historically, immunization of female mice or humans with either sperm or their extracts led to the production of anti-sperm antibodies (ASA) and infertility. However, these studies had a drawback of the presence of several proteins that were shared by other somatic cells. It is critical that antibodies developed by contraceptive vaccine based on sperm-specific proteins should not react with any other somatic cells. Candidate immunogens should either have a fertility-related function that can be blocked by antibody or be located on the sperm surface for ASA to affect sperm motility in the oviduct, uterus, cervix, or vagina. Many sperm antigens identified have potential; however, no single protein fulfills all the criteria necessary for a human vaccine. Therefore, some researchers have opted for construction of multi-antigen vaccines as a mechanism to overcome the limitations of a single molecule. There is also a new idea to engineer monoclonal antibody-based multipurpose prevention technology (MPT) products to address serious problems in female reproductive health, such as highly prevalent sexually transmitted infections and unplanned pregnancies." @default.
- W4293111637 created "2022-08-26" @default.
- W4293111637 creator A5010660159 @default.
- W4293111637 date "2022-01-01" @default.
- W4293111637 modified "2023-09-24" @default.
- W4293111637 title "Development of Immunocontraceptives in Female" @default.
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