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• W4293113303 abstract "As patents for multiple sclerosis (MS) therapies expire, follow-on disease-modifying treatments (FO-DMTs) become available at reduced cost. Concerns exist that cheaper FO-DMTs are used simply to reduce healthcare costs. However, the well-being of people with MS should take priority.To identify best practices for FO-DMT development and use by agreeing on principles and consensus statements through appraisal of published evidence.Following a systematic review, we formulated five overarching principles and 13 consensus statements. Principles and statements were voted on by a multidisciplinary panel from 17 European countries, Argentina, Canada and the United States.All principles and statements were endorsed by >80% of panellists. In brief, FO-DMTs approved within highly regulated areas can be considered effective and safe as their reference products; FO-DMTs can be evaluated case by case and do not always require Phase III trials; long-term pharmacovigilance and transparency are needed; there is lack of evidence for multiple- and cross-switching among FO-DMTs; and education is needed to address remaining concerns.Published data support the use of FO-DMTs in MS. The consensus may aid shared decision-making. While our consensus focused on Europe, the results may contribute to enhanced quality standards for FO-DMTs use elsewhere." @default.
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• W4293113303 date "2022-08-24" @default.
• W4293113303 modified "2023-09-27" @default.
• W4293113303 title "Use of follow-on disease-modifying treatments for multiple sclerosis: Consensus recommendations" @default.
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• W4293113303 doi "https://doi.org/10.1177/13524585221116269" @default.
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