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- W4293150208 abstract "Abstract Purpose To explore the value of umbilical artery cord blood glucose (UACBG) in predicting hypoglycemia in gestational diabetes mellitus (GDM) and other at-risk newborns, and to provide a cut-off UACBG value for predicting hypoglycemia occurrence. Methods In this prospective study, we enrolled at-risk infants delivered vaginally, including neonates born to mothers with GDM, premature, macrosomia, and low birth weight. We separated the infants into GDM group and other at-risk group. All subjects underwent UACBG measurement during delivery. Neonatal peripheral blood glucose measurement was performed at 0.5 h and 2 h after birth. The predictive performance of UACBG for neonatal hypoglycemia was assessed using receiver operating characteristic curve (ROC), area under curve (AUC), sensitivity and specificity. Results 916 newborns were included, 538 in GDM group and 378 in other at-risk group. For hypoglycemia prediction within 2 h, the best cut-off of UACBG was 4.150 mmol/L, yielding an AUC of 0.688 (95% CI 0.625–0.751). UACBG had a better performance at 0.5 h (AUC 0.757; 95% CI 0.690–0.824). In detail, the AUC was 0.703 in GDM group (95% CI 0.594–0.811), with the optimal cut-off of 4.550 mmol/L. In other at-risk group, the AUC was 0.797(95% CI 0.716–0.877), and the best threshold was 4.350 mmol/L. No significant differences were observed between GDM group and other at-risk group in AUC at 0.5 h, 2 h and within 2 h. Conclusions UACBG may be an efficient, non-invasive approach to predicting neonatal hypoglycemia within 2 h after birth." @default.
- W4293150208 created "2022-08-27" @default.
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- W4293150208 date "2022-08-26" @default.
- W4293150208 modified "2023-09-27" @default.
- W4293150208 title "Umbilical Artery Cord Blood Glucose Predicted neonatal hypoglycemia in Gestational Diabetes Mellitus and Other at-risk Newborns after Vaginal Delivery" @default.
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- W4293150208 doi "https://doi.org/10.21203/rs.3.rs-1958011/v1" @default.
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