FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293162191> ?p ?o ?g. }

• W4293162191 abstract "Abstract The antidiabetic action of traditional plants is mostly attributed to their antioxidant and anti-inflammatory properties. These plants are still having some secrets, making them an attractive source that allows for investigating new drugs or uncovering precise pharmacologic antidiabetic functions of their constituents. In diabetes, which is a lipid disease, long-term exposure of pancreatic islet beta cells to fatty acids (FAs) increases basal insulin release, reduces glucose-stimulated insulin secretion, causes islet beta cell inflammation, failure and apoptosis. Pancreatic islet beta cells express fatty acid binding protein 3 (FABP3) that receives long-chain FAs and traffics them throughout different cellular compartments to be metabolized and render their effects. Inhibition of this FABP3 may retard FA metabolism and protect islet beta cells. Since FAs interact with FABPs by their carboxylic group, some traditionally-known antidiabetic plants were reviewed in the present study, searching for their components that have common features of FABP ligands, namely carboxylic group and hydrophobic tail. Many of these carboxylic acids were computationally introduced into the ligand-binding pocket of FABP3 and some of them exhibited FABP3 ligand possibilities. Among others, the naturally occurring ferulic, cleomaldeic, caffeic, sinapic, hydroxycinnamic, 4-p-coumaroylquinic, quinoline-2-carboxylic, chlorogenic, 6-hydroxykynurenic, and rosmarinic acids in many plants are promising candidates for being FABP3-specific inhibitors. The study shed light on repurposing these phyto-carboxylic acids to function as FABP inhibitors. However, more in-depth biological and pharmacological studies to broaden the understanding of this function are needed." @default.
• W4293162191 created "2022-08-27" @default.
• W4293162191 creator A5025513986 @default.
• W4293162191 date "2022-08-26" @default.
• W4293162191 modified "2023-09-27" @default.
• W4293162191 title "Naturally-occurring carboxylic acids from traditional antidiabetic plants as potential pancreatic islet FABP3 inhibitors. A molecular docking–aided study" @default.
• W4293162191 cites W1174839022 @default.
• W4293162191 cites W13114764 @default.
• W4293162191 cites W1410665901 @default.
• W4293162191 cites W1480390900 @default.
• W4293162191 cites W1485082019 @default.
• W4293162191 cites W1556647562 @default.
• W4293162191 cites W1576950583 @default.
• W4293162191 cites W1672605608 @default.
• W4293162191 cites W1796726690 @default.
• W4293162191 cites W1872721533 @default.
• W4293162191 cites W1925840058 @default.
• W4293162191 cites W1953554152 @default.
• W4293162191 cites W1954830638 @default.
• W4293162191 cites W1966851729 @default.
• W4293162191 cites W1967103312 @default.
• W4293162191 cites W1968548517 @default.
• W4293162191 cites W1972168184 @default.
• W4293162191 cites W1973739905 @default.
• W4293162191 cites W1974457613 @default.
• W4293162191 cites W1975028084 @default.
• W4293162191 cites W1976161490 @default.
• W4293162191 cites W1978486320 @default.
• W4293162191 cites W1978751105 @default.
• W4293162191 cites W1979821638 @default.
• W4293162191 cites W1980321222 @default.
• W4293162191 cites W1980725298 @default.
• W4293162191 cites W1983525803 @default.
• W4293162191 cites W1986429259 @default.
• W4293162191 cites W1989949213 @default.
• W4293162191 cites W1992719447 @default.
• W4293162191 cites W1996476188 @default.
• W4293162191 cites W1997160312 @default.
• W4293162191 cites W1999597037 @default.
• W4293162191 cites W2000999406 @default.
• W4293162191 cites W2001083115 @default.
• W4293162191 cites W2003837139 @default.
• W4293162191 cites W2006204606 @default.
• W4293162191 cites W2007943381 @default.
• W4293162191 cites W2008351734 @default.
• W4293162191 cites W2009746612 @default.
• W4293162191 cites W2012123328 @default.
• W4293162191 cites W2013276134 @default.
• W4293162191 cites W2017081525 @default.
• W4293162191 cites W2020682428 @default.
• W4293162191 cites W2023098474 @default.
• W4293162191 cites W2027815046 @default.
• W4293162191 cites W2029486994 @default.
• W4293162191 cites W2039618147 @default.
• W4293162191 cites W2040358658 @default.
• W4293162191 cites W2042591688 @default.
• W4293162191 cites W2047550953 @default.
• W4293162191 cites W2047780133 @default.
• W4293162191 cites W2049921712 @default.
• W4293162191 cites W2050841989 @default.
• W4293162191 cites W2050927557 @default.
• W4293162191 cites W2051361465 @default.
• W4293162191 cites W2052378749 @default.
• W4293162191 cites W2052434029 @default.
• W4293162191 cites W2053120221 @default.
• W4293162191 cites W2060459047 @default.
• W4293162191 cites W2060952287 @default.
• W4293162191 cites W2062187201 @default.
• W4293162191 cites W2064482859 @default.
• W4293162191 cites W2065504943 @default.
• W4293162191 cites W2065914486 @default.
• W4293162191 cites W2067187286 @default.
• W4293162191 cites W2070237777 @default.
• W4293162191 cites W2071486660 @default.
• W4293162191 cites W2072759872 @default.
• W4293162191 cites W2073327039 @default.
• W4293162191 cites W2073739784 @default.
• W4293162191 cites W2074895860 @default.
• W4293162191 cites W2080012295 @default.
• W4293162191 cites W2086732410 @default.
• W4293162191 cites W2087286594 @default.
• W4293162191 cites W2087322848 @default.
• W4293162191 cites W2090608460 @default.
• W4293162191 cites W2091258310 @default.
• W4293162191 cites W2093563230 @default.
• W4293162191 cites W2103530895 @default.
• W4293162191 cites W2104213687 @default.
• W4293162191 cites W2104376530 @default.
• W4293162191 cites W2117242354 @default.
• W4293162191 cites W2117447523 @default.
• W4293162191 cites W2124847962 @default.
• W4293162191 cites W2132273751 @default.
• W4293162191 cites W2132537184 @default.
• W4293162191 cites W2135128485 @default.
• W4293162191 cites W2138698367 @default.
• W4293162191 cites W2142517328 @default.
• W4293162191 cites W2147073885 @default.
• W4293162191 cites W2147393987 @default.
• W4293162191 cites W2151356634 @default.
• W4293162191 cites W2160317880 @default.

• next