Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293171182> ?p ?o ?g. }
- W4293171182 endingPage "2000" @default.
- W4293171182 startingPage "1982" @default.
- W4293171182 abstract "ATPase family AAA-domain containing protein 3A (ATAD3A) is a nuclear encoded mitochondrial membrane protein that spans inner and outer membrane, and it has been shown to regulate mitochondrial dynamics and cholesterol metabolism. Since the mitochondrial functions have been implicated for osteogenic differentiation, a role of ATAD3A in skeletal development has been investigated.Mesenchyme-specific ATAD3 knockout mice displayed severe defects in skeletal development. Additionally, osteoblast-specific deletion of ATAD3 in mice caused significant reduction in bone mass, while cartilage-specific ATAD3 knockout mice did not show any significant phenotypes. Consistent with these in vivo findings, ATAD3A knockdown impaired mitochondrial morphology and function in calvarial pre-osteoblast cultures, which, in turn, suppressed osteogenic differentiation in vitro.The current findings suggest that ATAD3A plays a crucial role in mitochondria homeostasis, which is required for osteogenic differentiation during skeletal development." @default.
- W4293171182 created "2022-08-27" @default.
- W4293171182 creator A5024566101 @default.
- W4293171182 creator A5048055715 @default.
- W4293171182 date "2022-09-10" @default.
- W4293171182 modified "2023-10-12" @default.
- W4293171182 title "Deletion of <scp>ATAD3A</scp> inhibits osteogenesis by impairing mitochondria structure and function in pre‐osteoblast" @default.
- W4293171182 cites W179761311 @default.
- W4293171182 cites W1901404250 @default.
- W4293171182 cites W1982778013 @default.
- W4293171182 cites W1985185038 @default.
- W4293171182 cites W1985990508 @default.
- W4293171182 cites W1988725811 @default.
- W4293171182 cites W1990630983 @default.
- W4293171182 cites W1994737927 @default.
- W4293171182 cites W2007841700 @default.
- W4293171182 cites W2014324845 @default.
- W4293171182 cites W2014716069 @default.
- W4293171182 cites W2018560344 @default.
- W4293171182 cites W2031529753 @default.
- W4293171182 cites W2043305070 @default.
- W4293171182 cites W2073239775 @default.
- W4293171182 cites W2076627274 @default.
- W4293171182 cites W2077307563 @default.
- W4293171182 cites W2085544097 @default.
- W4293171182 cites W2091734792 @default.
- W4293171182 cites W2121708869 @default.
- W4293171182 cites W2133445929 @default.
- W4293171182 cites W2138736783 @default.
- W4293171182 cites W2142046597 @default.
- W4293171182 cites W2150013759 @default.
- W4293171182 cites W2163665758 @default.
- W4293171182 cites W2178164954 @default.
- W4293171182 cites W2182559934 @default.
- W4293171182 cites W2326274978 @default.
- W4293171182 cites W2407494057 @default.
- W4293171182 cites W2520289738 @default.
- W4293171182 cites W2607778027 @default.
- W4293171182 cites W2619794108 @default.
- W4293171182 cites W2736706431 @default.
- W4293171182 cites W2754142482 @default.
- W4293171182 cites W2756212562 @default.
- W4293171182 cites W2807984492 @default.
- W4293171182 cites W28261790 @default.
- W4293171182 cites W2886392733 @default.
- W4293171182 cites W2946174271 @default.
- W4293171182 cites W3084130987 @default.
- W4293171182 cites W4200074010 @default.
- W4293171182 cites W4255492705 @default.
- W4293171182 doi "https://doi.org/10.1002/dvdy.528" @default.
- W4293171182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36000457" @default.
- W4293171182 hasPublicationYear "2022" @default.
- W4293171182 type Work @default.
- W4293171182 citedByCount "1" @default.
- W4293171182 countsByYear W42931711822023 @default.
- W4293171182 crossrefType "journal-article" @default.
- W4293171182 hasAuthorship W4293171182A5024566101 @default.
- W4293171182 hasAuthorship W4293171182A5048055715 @default.
- W4293171182 hasConcept C104317684 @default.
- W4293171182 hasConcept C127716648 @default.
- W4293171182 hasConcept C134018914 @default.
- W4293171182 hasConcept C170493617 @default.
- W4293171182 hasConcept C173396325 @default.
- W4293171182 hasConcept C182704531 @default.
- W4293171182 hasConcept C198826908 @default.
- W4293171182 hasConcept C202751555 @default.
- W4293171182 hasConcept C2776340970 @default.
- W4293171182 hasConcept C2778260815 @default.
- W4293171182 hasConcept C2779959927 @default.
- W4293171182 hasConcept C28859421 @default.
- W4293171182 hasConcept C55493867 @default.
- W4293171182 hasConcept C75385678 @default.
- W4293171182 hasConcept C86803240 @default.
- W4293171182 hasConcept C95444343 @default.
- W4293171182 hasConceptScore W4293171182C104317684 @default.
- W4293171182 hasConceptScore W4293171182C127716648 @default.
- W4293171182 hasConceptScore W4293171182C134018914 @default.
- W4293171182 hasConceptScore W4293171182C170493617 @default.
- W4293171182 hasConceptScore W4293171182C173396325 @default.
- W4293171182 hasConceptScore W4293171182C182704531 @default.
- W4293171182 hasConceptScore W4293171182C198826908 @default.
- W4293171182 hasConceptScore W4293171182C202751555 @default.
- W4293171182 hasConceptScore W4293171182C2776340970 @default.
- W4293171182 hasConceptScore W4293171182C2778260815 @default.
- W4293171182 hasConceptScore W4293171182C2779959927 @default.
- W4293171182 hasConceptScore W4293171182C28859421 @default.
- W4293171182 hasConceptScore W4293171182C55493867 @default.
- W4293171182 hasConceptScore W4293171182C75385678 @default.
- W4293171182 hasConceptScore W4293171182C86803240 @default.
- W4293171182 hasConceptScore W4293171182C95444343 @default.
- W4293171182 hasIssue "12" @default.
- W4293171182 hasLocation W42931711821 @default.
- W4293171182 hasLocation W42931711822 @default.
- W4293171182 hasOpenAccess W4293171182 @default.
- W4293171182 hasPrimaryLocation W42931711821 @default.
- W4293171182 hasRelatedWork W1489148714 @default.
- W4293171182 hasRelatedWork W1980760536 @default.
- W4293171182 hasRelatedWork W1983177105 @default.