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- W4293172148 abstract "I discuss the historical background of the original proposals and modern versions of the selected theories of the molecular mechanisms of biological aging, i.e., the mutationMutation or genome instabilityGenome instability theory, the free radicalFree radical or oxidative stressOxidative stress theory, the mitochondrial theory, the error catastropheError catastrophe theory, the altered proteinAltered protein or protein homeostasis or proteostasisProteostasis theory, the dysdifferentiationDysdifferentiation or epigeneticEpigenetic theory, and the hyperfunctionHyperfunction theory, adding a brief comment on a recent popular theory of “epigenetic clock” in this revised version of my previous overview (Goto, Aging mechanisms. Longevity, metabolism and brain aging, Springer, Berlin, 2015). I have involved the development of some of the theories, which are therefore described in more detail than others. A discussion on the definition of aging and general comments on the aging theory are described. A most popular theory of aging, the free radical or oxidative theory, was proposed more than half a century ago but has recently faced severe criticisms to which I shall refer. So far, no single theory has been able to successfully explain the mechanism of biological aging. We are thus awaiting emergence of a new paradigm or an integration of the existing theories for better understanding of the mechanism." @default.
- W4293172148 created "2022-08-27" @default.
- W4293172148 creator A5048939598 @default.
- W4293172148 date "2022-01-01" @default.
- W4293172148 modified "2023-09-25" @default.
- W4293172148 title "An Unsolved Problem in Gerontology Yet: Molecular Mechanisms of Biological Aging—A Historical and Critical Overview" @default.
- W4293172148 cites W1485088846 @default.
- W4293172148 cites W1514296965 @default.
- W4293172148 cites W1515890326 @default.
- W4293172148 cites W1567614586 @default.
- W4293172148 cites W1580561229 @default.
- W4293172148 cites W1590553747 @default.
- W4293172148 cites W1697139149 @default.
- W4293172148 cites W1782287000 @default.
- W4293172148 cites W1831033366 @default.
- W4293172148 cites W1940436875 @default.
- W4293172148 cites W1963740353 @default.
- W4293172148 cites W1966429519 @default.
- W4293172148 cites W1966640763 @default.
- W4293172148 cites W1968297117 @default.
- W4293172148 cites W1972545676 @default.
- W4293172148 cites W1974047233 @default.
- W4293172148 cites W1978137073 @default.
- W4293172148 cites W1978489126 @default.
- W4293172148 cites W1980145665 @default.
- W4293172148 cites W1983387941 @default.
- W4293172148 cites W1987973250 @default.
- W4293172148 cites W1990040633 @default.
- W4293172148 cites W1991185361 @default.
- W4293172148 cites W1992091136 @default.
- W4293172148 cites W1994595131 @default.
- W4293172148 cites W1999493217 @default.
- W4293172148 cites W2001628753 @default.
- W4293172148 cites W2002176403 @default.
- W4293172148 cites W2002370374 @default.
- W4293172148 cites W2002899427 @default.
- W4293172148 cites W2004002095 @default.
- W4293172148 cites W2004112725 @default.
- W4293172148 cites W2006287843 @default.
- W4293172148 cites W2008329852 @default.
- W4293172148 cites W2011397216 @default.
- W4293172148 cites W2012675260 @default.
- W4293172148 cites W2014267717 @default.
- W4293172148 cites W2014320780 @default.
- W4293172148 cites W2014892893 @default.
- W4293172148 cites W2015607124 @default.
- W4293172148 cites W2021612469 @default.
- W4293172148 cites W2023897708 @default.
- W4293172148 cites W2024782183 @default.
- W4293172148 cites W2025133084 @default.
- W4293172148 cites W2027831836 @default.
- W4293172148 cites W2032057313 @default.
- W4293172148 cites W2034108516 @default.
- W4293172148 cites W2038510075 @default.
- W4293172148 cites W2039196160 @default.
- W4293172148 cites W2044287438 @default.
- W4293172148 cites W2044897807 @default.
- W4293172148 cites W2044982590 @default.
- W4293172148 cites W2050008896 @default.
- W4293172148 cites W2053450572 @default.
- W4293172148 cites W2053908717 @default.
- W4293172148 cites W2055761091 @default.
- W4293172148 cites W2056673369 @default.
- W4293172148 cites W2056751438 @default.
- W4293172148 cites W2057233739 @default.
- W4293172148 cites W2058484936 @default.
- W4293172148 cites W2059892363 @default.
- W4293172148 cites W2062776142 @default.
- W4293172148 cites W2062834833 @default.
- W4293172148 cites W2063770747 @default.
- W4293172148 cites W2063985582 @default.
- W4293172148 cites W2064853445 @default.
- W4293172148 cites W2066668773 @default.
- W4293172148 cites W2066775858 @default.
- W4293172148 cites W2068337326 @default.
- W4293172148 cites W2068909377 @default.
- W4293172148 cites W2069049877 @default.
- W4293172148 cites W2074303856 @default.
- W4293172148 cites W2074616759 @default.
- W4293172148 cites W2075308841 @default.
- W4293172148 cites W2076135478 @default.
- W4293172148 cites W2076830701 @default.
- W4293172148 cites W2078152795 @default.
- W4293172148 cites W2083718982 @default.
- W4293172148 cites W2085382072 @default.
- W4293172148 cites W2087249338 @default.
- W4293172148 cites W2087561593 @default.
- W4293172148 cites W2088611980 @default.
- W4293172148 cites W2089893520 @default.
- W4293172148 cites W2097647470 @default.
- W4293172148 cites W2098689751 @default.
- W4293172148 cites W2101760617 @default.
- W4293172148 cites W2105537673 @default.
- W4293172148 cites W2112365416 @default.
- W4293172148 cites W2114845975 @default.
- W4293172148 cites W2115708356 @default.
- W4293172148 cites W2117396891 @default.
- W4293172148 cites W2117517043 @default.