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- W4293172203 abstract "Excessive loss of dopaminergic neurons leads to Parkinson’s disease (PD)Parkinson’s disease (PD), the most common neurodegenerative disorder characterized by the loss of nigrostriatal dopamine-producing neurons. Based on the epidemiological studies, agingAging is the greatest risk factor for developing PD. However, the correlation between age-related cellular mechanisms and the degeneration of dopaminergic neuronsDopaminergic neurons remain unclear. In order to elucidate the pathogenesis of PD, we generated genetically modified mice and measured both dopaminergic neuronal lossNeuronal loss and motor phenotype over an extended period of time. These PD model mice exhibited age-dependent locomotor impairments, including hindlimb defects and the number of dopaminergic neurons decreased in aged mice, contributing to locomotor dysfunction. We present evidence from our work on dopaminergic neurons of aged mice that demonstrate the markers including impaired proteolysis, mitochondriaMitochondria damage and inflammation, which increase with advancing age. We contend that aging exaggerated dopaminergic neurons vulnerable to degeneration in PD." @default.
- W4293172203 created "2022-08-27" @default.
- W4293172203 creator A5009187834 @default.
- W4293172203 creator A5014705038 @default.
- W4293172203 date "2022-01-01" @default.
- W4293172203 modified "2023-09-29" @default.
- W4293172203 title "Aging and Parkinson’s Disease: Pathological Insight on Model Mice" @default.
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- W4293172203 doi "https://doi.org/10.1007/978-981-16-7977-3_23" @default.
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