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- W4293176211 startingPage "198" @default.
- W4293176211 abstract "Voltage-gated sodium and calcium channels (VGSCs and VGCCs) play an important role in the modulation of physiologically relevant processes in excitable cells that range from action potential generation to neurotransmission. Once their expression and/or function is altered in disease, specific pharmacological approaches become necessary to mitigate the negative consequences of such dysregulation. Several classes of small molecules have been developed with demonstrated effectiveness on VGSCs and VGCCs; however, off-target effects have also been described, limiting their use and spurring efforts to find more specific and safer molecules to target these channels. There are a great number of plants and herbal preparations that have been empirically used for the treatment of diseases in which VGSCs and VGCCs are involved. Some of these natural products have progressed to clinical trials, while others are under investigation for their action mechanisms on signaling pathways, including channels. In this review, we synthesize information from ~30 compounds derived from natural sources like plants and fungi and delineate their effects on VGSCs and VGCCs in human disease, particularly pain. [Figure: see text]." @default.
- W4293176211 created "2022-08-27" @default.
- W4293176211 creator A5012031138 @default.
- W4293176211 creator A5023972588 @default.
- W4293176211 creator A5029258341 @default.
- W4293176211 creator A5029295260 @default.
- W4293176211 date "2022-08-26" @default.
- W4293176211 modified "2023-10-17" @default.
- W4293176211 title "Plant and fungi derived analgesic natural products targeting voltage-gated sodium and calcium channels" @default.
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