Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293182783> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4293182783 endingPage "23" @default.
- W4293182783 startingPage "17" @default.
- W4293182783 abstract "Background: Urea derivatives showed good analgesic activity compared to diclofenac sodium. The addition of the allyl group to the thiourea and 4-tertiary-butylbenzoyl chlorideis expected to provide a better analgesic effect. Objective: The research aimed to synthesize 1-allyl-3-(4-tertiary-Butylbenzoyl) Thiourea and determine its analgesic activity in mice (Mus musculus). Methods: The synthesis was carried out by a modified Schotten-Baumann reaction, via nucleophilic substitution reaction of allylthiourea on 4-tertiary-butylbenzoyl chloride. A writhing test was performed to observe analgesic activity in the test compound. Confirmation of the structure of pure 1-allyl-3-(4-tertiary-Butylbenzoyl) Thiourea was obtained through UV, IR, 1H-NMR, and 13C-NMR data. Results: The compound showed better pain inhibition activity compared to diclofenac sodium, with ED5019,018 mg/kg BW. Conclusion: The compound 1-allyl-3-(4-tertiary-butylbenzoyl) thiourea showed better analgesic activity than diclofenac sodium." @default.
- W4293182783 created "2022-08-27" @default.
- W4293182783 creator A5000464099 @default.
- W4293182783 creator A5016392065 @default.
- W4293182783 creator A5062578848 @default.
- W4293182783 date "2022-04-26" @default.
- W4293182783 modified "2023-09-30" @default.
- W4293182783 title "Synthesis and Activity Test of 1-Allyl-3-(4-tertiary-Butylbenzoyl) Thioureaas a Candidate of an Analgesic Drug" @default.
- W4293182783 doi "https://doi.org/10.20473/jfiki.v9i12022.17-23" @default.
- W4293182783 hasPublicationYear "2022" @default.
- W4293182783 type Work @default.
- W4293182783 citedByCount "0" @default.
- W4293182783 crossrefType "journal-article" @default.
- W4293182783 hasAuthorship W4293182783A5000464099 @default.
- W4293182783 hasAuthorship W4293182783A5016392065 @default.
- W4293182783 hasAuthorship W4293182783A5062578848 @default.
- W4293182783 hasBestOaLocation W42931827831 @default.
- W4293182783 hasConcept C135731615 @default.
- W4293182783 hasConcept C178790620 @default.
- W4293182783 hasConcept C185592680 @default.
- W4293182783 hasConcept C2779826273 @default.
- W4293182783 hasConcept C2780365088 @default.
- W4293182783 hasConcept C2780538656 @default.
- W4293182783 hasConcept C2780820201 @default.
- W4293182783 hasConcept C2908765736 @default.
- W4293182783 hasConcept C43617362 @default.
- W4293182783 hasConcept C55493867 @default.
- W4293182783 hasConcept C71924100 @default.
- W4293182783 hasConcept C98274493 @default.
- W4293182783 hasConceptScore W4293182783C135731615 @default.
- W4293182783 hasConceptScore W4293182783C178790620 @default.
- W4293182783 hasConceptScore W4293182783C185592680 @default.
- W4293182783 hasConceptScore W4293182783C2779826273 @default.
- W4293182783 hasConceptScore W4293182783C2780365088 @default.
- W4293182783 hasConceptScore W4293182783C2780538656 @default.
- W4293182783 hasConceptScore W4293182783C2780820201 @default.
- W4293182783 hasConceptScore W4293182783C2908765736 @default.
- W4293182783 hasConceptScore W4293182783C43617362 @default.
- W4293182783 hasConceptScore W4293182783C55493867 @default.
- W4293182783 hasConceptScore W4293182783C71924100 @default.
- W4293182783 hasConceptScore W4293182783C98274493 @default.
- W4293182783 hasIssue "1" @default.
- W4293182783 hasLocation W42931827831 @default.
- W4293182783 hasLocation W42931827832 @default.
- W4293182783 hasOpenAccess W4293182783 @default.
- W4293182783 hasPrimaryLocation W42931827831 @default.
- W4293182783 hasRelatedWork W1988068904 @default.
- W4293182783 hasRelatedWork W2042117819 @default.
- W4293182783 hasRelatedWork W2049131783 @default.
- W4293182783 hasRelatedWork W2102548330 @default.
- W4293182783 hasRelatedWork W2153096616 @default.
- W4293182783 hasRelatedWork W2353344284 @default.
- W4293182783 hasRelatedWork W2953038696 @default.
- W4293182783 hasRelatedWork W3195914969 @default.
- W4293182783 hasRelatedWork W4293182783 @default.
- W4293182783 hasRelatedWork W2182844372 @default.
- W4293182783 hasVolume "9" @default.
- W4293182783 isParatext "false" @default.
- W4293182783 isRetracted "false" @default.
- W4293182783 workType "article" @default.