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• W4293199478 abstract "Abstract BACKGROUND Colletotrichum gloeosporioides causes anthracnose in a large number of crops. Synthetic fungicides are employed to prevent this disease, even though their effectiveness and safety is questionable. Thus, effective and innocuous antifungal compounds are proposed as natural alternatives against anthracnose. The hexane fraction of Vitex mollis pulp (HF‐VM) reduces anthracnose incidence in papaya fruit; however, the active compounds and antifungal mechanism of HF‐VM are unknown. The aims of this study were to characterize the activity of HF‐VM sub‐fractions (sHF 1 –sHF 7 ) against a thiabendazole‐resistant Colletotrichum gloeosporioides strain, identify the chemical components and investigate the mechanism of the most active sub‐fraction. RESULTS The sHF 3 showed the highest inhibitory activity against Colletotrichum gloeosporioides with a minimal inhibitory concentration (MIC) of 0.5 mg mL −1 , whereas thiabendazole (TBZ) had a MIC value higher than 2 mg mL −1 . The gas chromatography–mass spectrometry (GC–MS) analysis showed that the compounds in sHF 3 were methyl 4‐decenoate, caprylic acid, and 24‐methylencycloartanol. These compounds are rarely found in fruits and are reported for the first time on Vitex species. The purified 24‐methylencycloartanol was inactive (MIC > 0.5 mg mL −1 ). In contrast, the commercial standard of caprylic acid presented an elevated activity (MIC = 0.125 mg mL −1 ), indicating that this compound is the main one responsible for the antifungal properties of sHF 3 . Furthermore, the sHF 3 inhibited the spore germination and induced membrane disruption in both the spore and mycelium of Colletotrichum gloeosporioides . CONCLUSION Vitex mollis fruit is a novel source of antifungal caprylic acid that could be employed as a marker to prepare standardized extracts with antifungal properties. © 2022 Society of Chemical Industry." @default.
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• W4293199478 date "2022-09-14" @default.
• W4293199478 modified "2023-09-26" @default.
• W4293199478 title "Caprylic acid in <i>Vitex mollis</i> fruit and its inhibitory activity against a thiabendazole‐resistant <i>Colletotrichum gloeosporioides</i> strain" @default.
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• W4293199478 doi "https://doi.org/10.1002/ps.7149" @default.
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