FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293200185> ?p ?o ?g. }

• W4293200185 abstract "ABSTRACT SULF1 and SULF2 are oncogenic in a number of human malignancies, including head and neck squamous cell carcinoma (HNSC). The function of these two heparan sulfate editing enzymes was previously considered largely redundant but the biology of cancer suggests differences that we explore in our RNAseq and RNAScope studies of HNSC and in a pan cancer analysis using the TCGA and CPTAC (proteomics) data. Our studies document a consistent upregulation of SULF1 and SULF2 in HNSC which is associated with poor survival outcomes. SULF2 expression increases in multiple malignancies but less consistently than SULF1, which uniformly increases in the tumor tissues and negatively impacts survival in several types of cancer. Meanwhile, SULF1 showed low expression in cancer cell lines and a scRNAseq study of HNSC shows that SULF1 is not supplied by epithelial tumor cells, like SULF2, but is secreted by cancer associated fibroblasts. Our RNAScope and PDX analysis of the HNSC tissues fully confirm the stromal source of SULF1 and explain the uniform impact of this enzyme on the biology of multiple malignancies. In summary, the SULF1 enzyme, supplied by a subset of cancer associated fibroblasts, is upregulated and negatively impacts HNSC survival at an early stage of the disease progression while the SULF2 enzyme, supplied by tumor cells, impacts survival at later stages of HNSC. This paradigm is common to multiple malignancies and suggests a potential for diagnostic and therapeutic targeting of the heparan sulfatases in cancer diseases." @default.
• W4293200185 created "2022-08-27" @default.
• W4293200185 creator A5017160110 @default.
• W4293200185 creator A5031771992 @default.
• W4293200185 creator A5032223922 @default.
• W4293200185 creator A5043819422 @default.
• W4293200185 creator A5052943309 @default.
• W4293200185 creator A5058613940 @default.
• W4293200185 creator A5072196170 @default.
• W4293200185 creator A5073225210 @default.
• W4293200185 creator A5081929979 @default.
• W4293200185 creator A5090941234 @default.
• W4293200185 date "2022-08-26" @default.
• W4293200185 modified "2023-09-25" @default.
• W4293200185 title "Extracellular heparan 6-O-endosulfatases SULF1 and SULF2 in HNSC and other malignancies" @default.
• W4293200185 cites W1561538460 @default.
• W4293200185 cites W1975510007 @default.
• W4293200185 cites W1996795546 @default.
• W4293200185 cites W2016927165 @default.
• W4293200185 cites W2018242510 @default.
• W4293200185 cites W2019777638 @default.
• W4293200185 cites W2028938330 @default.
• W4293200185 cites W2041091423 @default.
• W4293200185 cites W2048358455 @default.
• W4293200185 cites W2054732153 @default.
• W4293200185 cites W2068007920 @default.
• W4293200185 cites W2074523891 @default.
• W4293200185 cites W2103526670 @default.
• W4293200185 cites W2108326699 @default.
• W4293200185 cites W2115721453 @default.
• W4293200185 cites W2126052429 @default.
• W4293200185 cites W2150561062 @default.
• W4293200185 cites W2151232299 @default.
• W4293200185 cites W2171199340 @default.
• W4293200185 cites W2275907046 @default.
• W4293200185 cites W2282071016 @default.
• W4293200185 cites W2320446052 @default.
• W4293200185 cites W2329674354 @default.
• W4293200185 cites W2507992840 @default.
• W4293200185 cites W2509844356 @default.
• W4293200185 cites W2547242076 @default.
• W4293200185 cites W2605919928 @default.
• W4293200185 cites W2611271374 @default.
• W4293200185 cites W2771542157 @default.
• W4293200185 cites W2795989238 @default.
• W4293200185 cites W2898292625 @default.
• W4293200185 cites W2899066274 @default.
• W4293200185 cites W2899204048 @default.
• W4293200185 cites W3020832878 @default.
• W4293200185 cites W3026934713 @default.
• W4293200185 cites W3109455351 @default.
• W4293200185 cites W3119265982 @default.
• W4293200185 cites W3119576751 @default.
• W4293200185 cites W3119681293 @default.
• W4293200185 cites W3136150112 @default.
• W4293200185 cites W3159221384 @default.
• W4293200185 cites W3186893239 @default.
• W4293200185 cites W3198094729 @default.
• W4293200185 cites W3199455993 @default.
• W4293200185 cites W3214208097 @default.
• W4293200185 cites W4211206272 @default.
• W4293200185 cites W4220657135 @default.
• W4293200185 cites W4221029688 @default.
• W4293200185 doi "https://doi.org/10.1101/2022.08.25.505356" @default.
• W4293200185 hasPublicationYear "2022" @default.
• W4293200185 type Work @default.
• W4293200185 citedByCount "1" @default.
• W4293200185 countsByYear W42932001852022 @default.
• W4293200185 crossrefType "posted-content" @default.
• W4293200185 hasAuthorship W4293200185A5017160110 @default.
• W4293200185 hasAuthorship W4293200185A5031771992 @default.
• W4293200185 hasAuthorship W4293200185A5032223922 @default.
• W4293200185 hasAuthorship W4293200185A5043819422 @default.
• W4293200185 hasAuthorship W4293200185A5052943309 @default.
• W4293200185 hasAuthorship W4293200185A5058613940 @default.
• W4293200185 hasAuthorship W4293200185A5072196170 @default.
• W4293200185 hasAuthorship W4293200185A5073225210 @default.
• W4293200185 hasAuthorship W4293200185A5081929979 @default.
• W4293200185 hasAuthorship W4293200185A5090941234 @default.
• W4293200185 hasBestOaLocation W42932001851 @default.
• W4293200185 hasConcept C104317684 @default.
• W4293200185 hasConcept C121608353 @default.
• W4293200185 hasConcept C127561419 @default.
• W4293200185 hasConcept C16930146 @default.
• W4293200185 hasConcept C502942594 @default.
• W4293200185 hasConcept C54355233 @default.
• W4293200185 hasConcept C55493867 @default.
• W4293200185 hasConcept C81885089 @default.
• W4293200185 hasConcept C86803240 @default.
• W4293200185 hasConcept C96232424 @default.
• W4293200185 hasConceptScore W4293200185C104317684 @default.
• W4293200185 hasConceptScore W4293200185C121608353 @default.
• W4293200185 hasConceptScore W4293200185C127561419 @default.
• W4293200185 hasConceptScore W4293200185C16930146 @default.
• W4293200185 hasConceptScore W4293200185C502942594 @default.
• W4293200185 hasConceptScore W4293200185C54355233 @default.
• W4293200185 hasConceptScore W4293200185C55493867 @default.
• W4293200185 hasConceptScore W4293200185C81885089 @default.
• W4293200185 hasConceptScore W4293200185C86803240 @default.
• W4293200185 hasConceptScore W4293200185C96232424 @default.

• next