Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293200751> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4293200751 endingPage "102893" @default.
- W4293200751 startingPage "102893" @default.
- W4293200751 abstract "Orally administered dimethyl fumarate (DMF) presents gastrointestinal adverse effects, such as pain and diarrhea, in addition to flushing and lymphopenia. Solid lipid nanoparticles (SLNs) with DMF were developed for subcutaneous administration. DMF-incorporated SLNs and free DMF were tested in mice induced with experimental autoimmune encephalomyelitis (EAE). Preventive treatment of free or incorporated DMF were able to reduce the EAE clinical scores, increase the weight of the animals, reduce the lesion area (demyelination and infiltration), reduce microglial fluorescence intensity and reduce the number of microglial cells and astrocytes, when compared to untreated EAE animals. Groups that received DMF had reduced numbers of T cells, B cells and natural killer (NK) cells in the blood, when compared to the non-induced group. DMF incorporated in SLNs was as effective as free DMF in reducing the clinical scores of the animals, but with reduced administrations when given subcutaneously. In addition, SLN-DMF preventive treatment partially prevented a reduction in the percentages of T and B cells, in the blood, when compared to preventive treatment with free DMF (oral), which suggests reduction of lymphopenia." @default.
- W4293200751 created "2022-08-27" @default.
- W4293200751 creator A5028633204 @default.
- W4293200751 creator A5040841530 @default.
- W4293200751 creator A5047084308 @default.
- W4293200751 creator A5066343970 @default.
- W4293200751 creator A5068995319 @default.
- W4293200751 creator A5089857638 @default.
- W4293200751 creator A5091001873 @default.
- W4293200751 date "2022-10-01" @default.
- W4293200751 modified "2023-10-06" @default.
- W4293200751 title "Comparative effectiveness of preventive treatment with dimethyl fumarate-loaded solid lipid nanoparticles and oral dimethyl fumarate in a mouse model of multiple sclerosis" @default.
- W4293200751 cites W1904083131 @default.
- W4293200751 cites W1978094617 @default.
- W4293200751 cites W1999768705 @default.
- W4293200751 cites W2019206211 @default.
- W4293200751 cites W2022905263 @default.
- W4293200751 cites W2027129171 @default.
- W4293200751 cites W2069907950 @default.
- W4293200751 cites W2093009907 @default.
- W4293200751 cites W2134494454 @default.
- W4293200751 cites W2143310289 @default.
- W4293200751 cites W2147779121 @default.
- W4293200751 cites W2150195459 @default.
- W4293200751 cites W2314741982 @default.
- W4293200751 cites W2756864941 @default.
- W4293200751 cites W2758514257 @default.
- W4293200751 cites W2759263875 @default.
- W4293200751 cites W2913644063 @default.
- W4293200751 cites W2999849218 @default.
- W4293200751 doi "https://doi.org/10.1016/j.jaut.2022.102893" @default.
- W4293200751 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36029715" @default.
- W4293200751 hasPublicationYear "2022" @default.
- W4293200751 type Work @default.
- W4293200751 citedByCount "0" @default.
- W4293200751 crossrefType "journal-article" @default.
- W4293200751 hasAuthorship W4293200751A5028633204 @default.
- W4293200751 hasAuthorship W4293200751A5040841530 @default.
- W4293200751 hasAuthorship W4293200751A5047084308 @default.
- W4293200751 hasAuthorship W4293200751A5066343970 @default.
- W4293200751 hasAuthorship W4293200751A5068995319 @default.
- W4293200751 hasAuthorship W4293200751A5089857638 @default.
- W4293200751 hasAuthorship W4293200751A5091001873 @default.
- W4293200751 hasConcept C126322002 @default.
- W4293200751 hasConcept C142724271 @default.
- W4293200751 hasConcept C197934379 @default.
- W4293200751 hasConcept C199529486 @default.
- W4293200751 hasConcept C203014093 @default.
- W4293200751 hasConcept C2776390293 @default.
- W4293200751 hasConcept C2776819417 @default.
- W4293200751 hasConcept C2777899865 @default.
- W4293200751 hasConcept C2778486448 @default.
- W4293200751 hasConcept C2779802037 @default.
- W4293200751 hasConcept C2780035454 @default.
- W4293200751 hasConcept C2780640218 @default.
- W4293200751 hasConcept C2781156865 @default.
- W4293200751 hasConcept C71924100 @default.
- W4293200751 hasConcept C90924648 @default.
- W4293200751 hasConcept C98274493 @default.
- W4293200751 hasConceptScore W4293200751C126322002 @default.
- W4293200751 hasConceptScore W4293200751C142724271 @default.
- W4293200751 hasConceptScore W4293200751C197934379 @default.
- W4293200751 hasConceptScore W4293200751C199529486 @default.
- W4293200751 hasConceptScore W4293200751C203014093 @default.
- W4293200751 hasConceptScore W4293200751C2776390293 @default.
- W4293200751 hasConceptScore W4293200751C2776819417 @default.
- W4293200751 hasConceptScore W4293200751C2777899865 @default.
- W4293200751 hasConceptScore W4293200751C2778486448 @default.
- W4293200751 hasConceptScore W4293200751C2779802037 @default.
- W4293200751 hasConceptScore W4293200751C2780035454 @default.
- W4293200751 hasConceptScore W4293200751C2780640218 @default.
- W4293200751 hasConceptScore W4293200751C2781156865 @default.
- W4293200751 hasConceptScore W4293200751C71924100 @default.
- W4293200751 hasConceptScore W4293200751C90924648 @default.
- W4293200751 hasConceptScore W4293200751C98274493 @default.
- W4293200751 hasLocation W42932007511 @default.
- W4293200751 hasLocation W42932007512 @default.
- W4293200751 hasOpenAccess W4293200751 @default.
- W4293200751 hasPrimaryLocation W42932007511 @default.
- W4293200751 hasRelatedWork W1983080093 @default.
- W4293200751 hasRelatedWork W2042881484 @default.
- W4293200751 hasRelatedWork W2092421291 @default.
- W4293200751 hasRelatedWork W2099318703 @default.
- W4293200751 hasRelatedWork W2395309609 @default.
- W4293200751 hasRelatedWork W2489033283 @default.
- W4293200751 hasRelatedWork W2990802025 @default.
- W4293200751 hasRelatedWork W3210293628 @default.
- W4293200751 hasRelatedWork W4238741551 @default.
- W4293200751 hasRelatedWork W1935049211 @default.
- W4293200751 hasVolume "132" @default.
- W4293200751 isParatext "false" @default.
- W4293200751 isRetracted "false" @default.
- W4293200751 workType "article" @default.