FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293206775> ?p ?o ?g. }

• W4293206775 endingPage "5458" @default.
• W4293206775 startingPage "5458" @default.
• W4293206775 abstract "Different aspects of intra-tumor heterogeneity (ITH), which are associated with the development of cancer and its response to treatment, have postulated prognostic value. Here we searched for potential association between phenotypic ITH analyzed by mass spectrometry imaging (MSI) and prognosis of head and neck cancer. The study involved tissue specimens resected from 77 patients with locally advanced oral squamous cell carcinoma, including 37 patients where matched samples of primary tumor and synchronous lymph node metastases were analyzed. A 3-year follow-up was available for all patients which enabled their separation into two groups: with no evidence of disease (NED, n = 41) and with progressive disease (PD, n = 36). After on-tissue trypsin digestion, peptide maps of all cancer regions were segmented using an unsupervised approach to reveal their intrinsic heterogeneity. We found that intra-tumor similarity of spectra was higher in the PD group and diversity of clusters identified during image segmentation was higher in the NED group, which indicated a higher level of ITH in patients with more favorable outcomes. Signature of molecular components that correlated with long-term outcomes could be associated with proteins involved in the immune functions. Furthermore, a positive correlation between ITH and histopathological lymphocytic host response was observed. Hence, we proposed that a higher level of ITH revealed by MSI in cancers with a better prognosis could reflect the presence of heterotypic components of tumor microenvironment such as infiltrating immune cells enhancing the response to the treatment." @default.
• W4293206775 created "2022-08-27" @default.
• W4293206775 creator A5009908756 @default.
• W4293206775 creator A5017612940 @default.
• W4293206775 creator A5032794040 @default.
• W4293206775 creator A5037979882 @default.
• W4293206775 creator A5043567122 @default.
• W4293206775 creator A5049923289 @default.
• W4293206775 creator A5050285030 @default.
• W4293206775 date "2022-08-25" @default.
• W4293206775 modified "2023-10-18" @default.
• W4293206775 title "Prognostic Value of Molecular Intratumor Heterogeneity in Primary Oral Cancer and Its Lymph Node Metastases Assessed by Mass Spectrometry Imaging" @default.
• W4293206775 cites W1585283825 @default.
• W4293206775 cites W1595906092 @default.
• W4293206775 cites W1957776961 @default.
• W4293206775 cites W1965011257 @default.
• W4293206775 cites W1967304777 @default.
• W4293206775 cites W1973419840 @default.
• W4293206775 cites W1976648974 @default.
• W4293206775 cites W1984566266 @default.
• W4293206775 cites W1987012261 @default.
• W4293206775 cites W2000345621 @default.
• W4293206775 cites W2023560061 @default.
• W4293206775 cites W2059383728 @default.
• W4293206775 cites W2062831861 @default.
• W4293206775 cites W2067256262 @default.
• W4293206775 cites W2087189381 @default.
• W4293206775 cites W2093734206 @default.
• W4293206775 cites W2105509337 @default.
• W4293206775 cites W2117692326 @default.
• W4293206775 cites W2135398071 @default.
• W4293206775 cites W2162871445 @default.
• W4293206775 cites W2182664595 @default.
• W4293206775 cites W2292534871 @default.
• W4293206775 cites W2292706359 @default.
• W4293206775 cites W2314168325 @default.
• W4293206775 cites W2537132940 @default.
• W4293206775 cites W2565715699 @default.
• W4293206775 cites W2585937913 @default.
• W4293206775 cites W2768627165 @default.
• W4293206775 cites W2792467729 @default.
• W4293206775 cites W2793226176 @default.
• W4293206775 cites W2898653554 @default.
• W4293206775 cites W2899760200 @default.
• W4293206775 cites W2920849031 @default.
• W4293206775 cites W2922223147 @default.
• W4293206775 cites W2968072769 @default.
• W4293206775 cites W2970294817 @default.
• W4293206775 cites W2971761467 @default.
• W4293206775 cites W2982699219 @default.
• W4293206775 cites W2996016044 @default.
• W4293206775 cites W3121642246 @default.
• W4293206775 cites W3128646645 @default.
• W4293206775 cites W3142571537 @default.
• W4293206775 cites W3165458352 @default.
• W4293206775 cites W3198150887 @default.
• W4293206775 cites W4233578221 @default.
• W4293206775 doi "https://doi.org/10.3390/molecules27175458" @default.
• W4293206775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36080226" @default.
• W4293206775 hasPublicationYear "2022" @default.
• W4293206775 type Work @default.
• W4293206775 citedByCount "1" @default.
• W4293206775 countsByYear W42932067752023 @default.
• W4293206775 crossrefType "journal-article" @default.
• W4293206775 hasAuthorship W4293206775A5009908756 @default.
• W4293206775 hasAuthorship W4293206775A5017612940 @default.
• W4293206775 hasAuthorship W4293206775A5032794040 @default.
• W4293206775 hasAuthorship W4293206775A5037979882 @default.
• W4293206775 hasAuthorship W4293206775A5043567122 @default.
• W4293206775 hasAuthorship W4293206775A5049923289 @default.
• W4293206775 hasAuthorship W4293206775A5050285030 @default.
• W4293206775 hasBestOaLocation W42932067751 @default.
• W4293206775 hasConcept C121608353 @default.
• W4293206775 hasConcept C126322002 @default.
• W4293206775 hasConcept C142724271 @default.
• W4293206775 hasConcept C143998085 @default.
• W4293206775 hasConcept C162356407 @default.
• W4293206775 hasConcept C185592680 @default.
• W4293206775 hasConcept C203014093 @default.
• W4293206775 hasConcept C24066741 @default.
• W4293206775 hasConcept C2776107976 @default.
• W4293206775 hasConcept C2776530083 @default.
• W4293206775 hasConcept C2776833033 @default.
• W4293206775 hasConcept C2779013556 @default.
• W4293206775 hasConcept C2780283643 @default.
• W4293206775 hasConcept C2780849966 @default.
• W4293206775 hasConcept C43617362 @default.
• W4293206775 hasConcept C502942594 @default.
• W4293206775 hasConcept C71924100 @default.
• W4293206775 hasConcept C8891405 @default.
• W4293206775 hasConceptScore W4293206775C121608353 @default.
• W4293206775 hasConceptScore W4293206775C126322002 @default.
• W4293206775 hasConceptScore W4293206775C142724271 @default.
• W4293206775 hasConceptScore W4293206775C143998085 @default.
• W4293206775 hasConceptScore W4293206775C162356407 @default.
• W4293206775 hasConceptScore W4293206775C185592680 @default.
• W4293206775 hasConceptScore W4293206775C203014093 @default.
• W4293206775 hasConceptScore W4293206775C24066741 @default.

• next