FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293211074> ?p ?o ?g. }

• W4293211074 endingPage "14" @default.
• W4293211074 startingPage "1" @default.
• W4293211074 abstract "Airway inflammation in asthma is managed with anti-inflammatory steroids such as dexamethasone (DEX). However, about 20% of asthmatics do not respond to this therapy and are classified as steroid-resistant. Currently, no effective therapy is available for steroid-resistant asthma. This work therefore evaluated the effect of a plant sterol, stigmasterol (STIG), and stigmasterol-dexamethasone combination (STIG+DEX) in LPS-ovalbumin-induced steroid-resistant asthma in Guinea pigs. To do this, the effect of drugs on inflammatory features such as airway hyperreactivity and histopathology of lung tissue was evaluated. Additionally, the possible pathway of drug action was assessed by measuring events such neutrophil levels, oxidative and nitrative stress, and histone deacetylase 2 (HDAC2) and interleukin 17 (IL-17) levels. STIG alone did not affect inflammatory features, although it caused some changes in the molecular events associated with steroid-resistant asthma. However, STIG+DEX caused significant modulation of inflammatory features by protecting against destruction of lung tissue. The modulation of inflammatory features was associated with significant inhibition of neutrophilia and oxidative and nitrative stress, decrease in HDAC2, and increase in IL-17 levels that are usually associated with steroid-resistant asthma. Our findings show that although STIG and DEX individually do not protect against steroid-resistant asthma, their coadministration results in significant modulation of inflammatory features and the associated molecular events that lead to steroid-resistant asthma." @default.
• W4293211074 created "2022-08-27" @default.
• W4293211074 creator A5001264445 @default.
• W4293211074 creator A5016674314 @default.
• W4293211074 creator A5030614775 @default.
• W4293211074 creator A5043613568 @default.
• W4293211074 creator A5059093145 @default.
• W4293211074 creator A5084955736 @default.
• W4293211074 date "2022-08-24" @default.
• W4293211074 modified "2023-10-17" @default.
• W4293211074 title "Coadministration of Stigmasterol and Dexamethasone (STIG+DEX) Modulates Steroid-Resistant Asthma" @default.
• W4293211074 cites W1500937540 @default.
• W4293211074 cites W1573518848 @default.
• W4293211074 cites W1750690213 @default.
• W4293211074 cites W1837564390 @default.
• W4293211074 cites W1954930651 @default.
• W4293211074 cites W1974024043 @default.
• W4293211074 cites W1976194871 @default.
• W4293211074 cites W1980105210 @default.
• W4293211074 cites W1982179711 @default.
• W4293211074 cites W2006370393 @default.
• W4293211074 cites W2027675155 @default.
• W4293211074 cites W2034575413 @default.
• W4293211074 cites W2039640602 @default.
• W4293211074 cites W2040252933 @default.
• W4293211074 cites W2052463028 @default.
• W4293211074 cites W2057930810 @default.
• W4293211074 cites W2081774119 @default.
• W4293211074 cites W2083606023 @default.
• W4293211074 cites W2087025400 @default.
• W4293211074 cites W2095618234 @default.
• W4293211074 cites W2096795975 @default.
• W4293211074 cites W2116519763 @default.
• W4293211074 cites W2128399547 @default.
• W4293211074 cites W2130337837 @default.
• W4293211074 cites W2133001264 @default.
• W4293211074 cites W2139901384 @default.
• W4293211074 cites W2141611143 @default.
• W4293211074 cites W2153866915 @default.
• W4293211074 cites W2156720570 @default.
• W4293211074 cites W2156761725 @default.
• W4293211074 cites W2346919977 @default.
• W4293211074 cites W2471332471 @default.
• W4293211074 cites W2528730307 @default.
• W4293211074 cites W2563471914 @default.
• W4293211074 cites W2598548669 @default.
• W4293211074 cites W2610255728 @default.
• W4293211074 cites W2614095148 @default.
• W4293211074 cites W2620241325 @default.
• W4293211074 cites W2743335049 @default.
• W4293211074 cites W2765307644 @default.
• W4293211074 cites W2805886339 @default.
• W4293211074 cites W2884682472 @default.
• W4293211074 cites W4312694073 @default.
• W4293211074 doi "https://doi.org/10.1155/2022/2222270" @default.
• W4293211074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36060927" @default.
• W4293211074 hasPublicationYear "2022" @default.
• W4293211074 type Work @default.
• W4293211074 citedByCount "1" @default.
• W4293211074 countsByYear W42932110742023 @default.
• W4293211074 crossrefType "journal-article" @default.
• W4293211074 hasAuthorship W4293211074A5001264445 @default.
• W4293211074 hasAuthorship W4293211074A5016674314 @default.
• W4293211074 hasAuthorship W4293211074A5030614775 @default.
• W4293211074 hasAuthorship W4293211074A5043613568 @default.
• W4293211074 hasAuthorship W4293211074A5059093145 @default.
• W4293211074 hasAuthorship W4293211074A5084955736 @default.
• W4293211074 hasBestOaLocation W42932110741 @default.
• W4293211074 hasConcept C126322002 @default.
• W4293211074 hasConcept C134018914 @default.
• W4293211074 hasConcept C203014093 @default.
• W4293211074 hasConcept C2776042228 @default.
• W4293211074 hasConcept C2776151105 @default.
• W4293211074 hasConcept C2780401358 @default.
• W4293211074 hasConcept C2780902042 @default.
• W4293211074 hasConcept C71315377 @default.
• W4293211074 hasConcept C71924100 @default.
• W4293211074 hasConcept C98274493 @default.
• W4293211074 hasConceptScore W4293211074C126322002 @default.
• W4293211074 hasConceptScore W4293211074C134018914 @default.
• W4293211074 hasConceptScore W4293211074C203014093 @default.
• W4293211074 hasConceptScore W4293211074C2776042228 @default.
• W4293211074 hasConceptScore W4293211074C2776151105 @default.
• W4293211074 hasConceptScore W4293211074C2780401358 @default.
• W4293211074 hasConceptScore W4293211074C2780902042 @default.
• W4293211074 hasConceptScore W4293211074C71315377 @default.
• W4293211074 hasConceptScore W4293211074C71924100 @default.
• W4293211074 hasConceptScore W4293211074C98274493 @default.
• W4293211074 hasLocation W42932110741 @default.
• W4293211074 hasLocation W42932110742 @default.
• W4293211074 hasLocation W42932110743 @default.
• W4293211074 hasLocation W42932110744 @default.
• W4293211074 hasOpenAccess W4293211074 @default.
• W4293211074 hasPrimaryLocation W42932110741 @default.
• W4293211074 hasRelatedWork W1982434602 @default.
• W4293211074 hasRelatedWork W2094844283 @default.
• W4293211074 hasRelatedWork W2354241142 @default.
• W4293211074 hasRelatedWork W2365729717 @default.

• next