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- W4293211965 abstract "The reaction medium plays a key role in organic synthesis and pharmaceutical research. There are many opinions on choosing the best condition, including cost and environmental implications, but the main requirement is that they have the necessary interaction with solvents to cause dissolution, precipitation, stabilization, or instability. For this purpose, in this article synthesis of the thiazole ring was made under various reaction conditions. So new compounds 2-(isoquinolin-5-ylimino)-3-phenylthiazolidin-4-one (1), (4-amino-3-phenylthiazol-2(3H)-ylidene) isoquinolin-5-amine (2), (4-amino-3-phenylthiazol-2(3H)-ylidene) isoquinolin-5-amine (3) were synthesized from the reaction between thiourea derivative and monochloroacetic acid, diethyloxalate and chloro acetonitrile. For this synthesizes were created in various reaction conditions, using different bases (sodium acetate/sodyum etoksit/ triethylamine or pyridine) and solvents (1,4-dioxane, toluene, acetic acid, ethanol, tetrahydrofuran, dimethyl formamide). At the end of these reactions, the best efficiency was obtained with the one-pot reaction using THF/DMF, Et3N. The structures of all novel compounds reported herein were established using FT-IR, 1H NMR, and 13C NMR spectra as well as elemental analysis technique." @default.
- W4293211965 created "2022-08-27" @default.
- W4293211965 creator A5056774755 @default.
- W4293211965 date "2022-08-31" @default.
- W4293211965 modified "2023-10-18" @default.
- W4293211965 title "Synthesis and Characterization of Thiazole Compounds in the Presence of Various Reagents, Catalysts and Solvents" @default.
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- W4293211965 doi "https://doi.org/10.16984/saufenbilder.950016" @default.
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