Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293217302> ?p ?o ?g. }
- W4293217302 endingPage "5860" @default.
- W4293217302 startingPage "5860" @default.
- W4293217302 abstract "Polyelectrolyte complexes (PECs), based on partially deacetylated chitin nanowhiskers (CNWs) and anionic polysaccharides, are characterized by their variability of properties (particle size, ζ-potential, and pH-sensitivity) depending on the preparation conditions, thereby allowing the development of polymeric nanoplatforms with a sustained release profile for active pharmaceutical substances. This study is focused on the development of hydrogels based on PECs of CNWs and sodium alginate (ALG) for potential vaginal administration that provide controlled pH-dependent antibiotic release in an acidic vaginal environment, as well as prolonged pharmacological action due to both the sustained drug release profile and the mucoadhesive properties of the polysaccharides. The desired hydrogels were formed as a result of both electrostatic interactions between CNWs and ALG (PEC formation), and the subsequent molecular entanglement of ALG chains, and the formation of additional hydrogen bonds. Metronidazole (MET) delivery systems with the desired properties were obtained at pH 5.5 and an CNW:ALG ratio of 1:2. The MET-CNW-ALG microparticles in the hydrogel composition had an apparent hydrodynamic diameter of approximately 1.7 µm and a ζ-potential of -43 mV. In vitro release studies showed a prolonged pH-sensitive drug release from the designed hydrogels; 37 and 67% of MET were released within 24 h at pH 7.4 and pH 4.5, respectively. The introduction of CNWs into the MET-ALG system not only prolonged the drug release, but also increased the mucoadhesive properties by about 1.3 times. Thus, novel CNW-ALG hydrogels are promising carriers for pH sensitive drug delivery carriers." @default.
- W4293217302 created "2022-08-27" @default.
- W4293217302 creator A5002802866 @default.
- W4293217302 creator A5039548532 @default.
- W4293217302 creator A5051627045 @default.
- W4293217302 creator A5084413044 @default.
- W4293217302 date "2022-08-25" @default.
- W4293217302 modified "2023-09-30" @default.
- W4293217302 title "pH-Sensitive Drug Delivery System Based on Chitin Nanowhiskers–Sodium Alginate Polyelectrolyte Complex" @default.
- W4293217302 cites W1963681285 @default.
- W4293217302 cites W1968484005 @default.
- W4293217302 cites W1976928264 @default.
- W4293217302 cites W2011308189 @default.
- W4293217302 cites W2040810538 @default.
- W4293217302 cites W2044853520 @default.
- W4293217302 cites W2045246594 @default.
- W4293217302 cites W2050885387 @default.
- W4293217302 cites W2058674497 @default.
- W4293217302 cites W2060037006 @default.
- W4293217302 cites W2067862842 @default.
- W4293217302 cites W2074782448 @default.
- W4293217302 cites W2075801777 @default.
- W4293217302 cites W2075843603 @default.
- W4293217302 cites W2086514756 @default.
- W4293217302 cites W2107042528 @default.
- W4293217302 cites W2132789515 @default.
- W4293217302 cites W2154400283 @default.
- W4293217302 cites W2328984514 @default.
- W4293217302 cites W2567538099 @default.
- W4293217302 cites W2580185994 @default.
- W4293217302 cites W2596287086 @default.
- W4293217302 cites W2767194483 @default.
- W4293217302 cites W2790608253 @default.
- W4293217302 cites W2810943981 @default.
- W4293217302 cites W2889444173 @default.
- W4293217302 cites W2895466432 @default.
- W4293217302 cites W2897075077 @default.
- W4293217302 cites W2913283575 @default.
- W4293217302 cites W2961770569 @default.
- W4293217302 cites W2963031695 @default.
- W4293217302 cites W3010291755 @default.
- W4293217302 cites W3014426136 @default.
- W4293217302 cites W3037672632 @default.
- W4293217302 cites W3049350155 @default.
- W4293217302 cites W3080913464 @default.
- W4293217302 cites W3081687669 @default.
- W4293217302 cites W3084885329 @default.
- W4293217302 cites W3116729428 @default.
- W4293217302 cites W3120507162 @default.
- W4293217302 cites W3121164577 @default.
- W4293217302 cites W3127946820 @default.
- W4293217302 cites W3132257088 @default.
- W4293217302 cites W3161212227 @default.
- W4293217302 cites W3164815556 @default.
- W4293217302 cites W3209556540 @default.
- W4293217302 cites W4283739732 @default.
- W4293217302 doi "https://doi.org/10.3390/ma15175860" @default.
- W4293217302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36079241" @default.
- W4293217302 hasPublicationYear "2022" @default.
- W4293217302 type Work @default.
- W4293217302 citedByCount "7" @default.
- W4293217302 countsByYear W42932173022022 @default.
- W4293217302 countsByYear W42932173022023 @default.
- W4293217302 crossrefType "journal-article" @default.
- W4293217302 hasAuthorship W4293217302A5002802866 @default.
- W4293217302 hasAuthorship W4293217302A5039548532 @default.
- W4293217302 hasAuthorship W4293217302A5051627045 @default.
- W4293217302 hasAuthorship W4293217302A5084413044 @default.
- W4293217302 hasBestOaLocation W42932173021 @default.
- W4293217302 hasConcept C100817775 @default.
- W4293217302 hasConcept C108586683 @default.
- W4293217302 hasConcept C127413603 @default.
- W4293217302 hasConcept C13245373 @default.
- W4293217302 hasConcept C153356533 @default.
- W4293217302 hasConcept C163588942 @default.
- W4293217302 hasConcept C171250308 @default.
- W4293217302 hasConcept C178790620 @default.
- W4293217302 hasConcept C185592680 @default.
- W4293217302 hasConcept C188027245 @default.
- W4293217302 hasConcept C192562407 @default.
- W4293217302 hasConcept C2779732960 @default.
- W4293217302 hasConcept C2779820397 @default.
- W4293217302 hasConcept C2781088250 @default.
- W4293217302 hasConcept C42360764 @default.
- W4293217302 hasConcept C521977710 @default.
- W4293217302 hasConceptScore W4293217302C100817775 @default.
- W4293217302 hasConceptScore W4293217302C108586683 @default.
- W4293217302 hasConceptScore W4293217302C127413603 @default.
- W4293217302 hasConceptScore W4293217302C13245373 @default.
- W4293217302 hasConceptScore W4293217302C153356533 @default.
- W4293217302 hasConceptScore W4293217302C163588942 @default.
- W4293217302 hasConceptScore W4293217302C171250308 @default.
- W4293217302 hasConceptScore W4293217302C178790620 @default.
- W4293217302 hasConceptScore W4293217302C185592680 @default.
- W4293217302 hasConceptScore W4293217302C188027245 @default.
- W4293217302 hasConceptScore W4293217302C192562407 @default.
- W4293217302 hasConceptScore W4293217302C2779732960 @default.
- W4293217302 hasConceptScore W4293217302C2779820397 @default.