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- W4293219195 endingPage "5843" @default.
- W4293219195 startingPage "5843" @default.
- W4293219195 abstract "Aggressive invasiveness is a common feature of malignant gliomas, despite their high level of tumor heterogeneity and possible diverse cell origins. Therefore, it is important to explore new therapeutic methods. In this study, we evaluated and compared the effects of graphene (GN) and reduced graphene oxides (rGOs) on a highly invasive and neoplastic cell line, U87. The surface functional groups of the GN and rGO flakes were characterized by X-ray photoelectron spectroscopy. The antitumor activity of these flakes was obtained by using the neutral red assay and their anti-migratory activity was determined using the wound healing assay. Further, we investigated the mRNA and protein expression levels of important cell adhesion molecules involved in migration and invasiveness. The rGO flakes, particularly rGO/ATS and rGO/TUD, were found highly toxic. The migration potential of both U87 and Hs5 cells decreased, especially after rGO/TUD treatment. A post-treatment decrease in mobility and FAK expression was observed in U87 cells treated with rGO/ATS and rGO/TUD flakes. The rGO/TUD treatment also reduced β-catenin expression in U87 cells. Our results suggest that rGO flakes reduce the migration and invasiveness of U87 tumor cells and can, thus, be used as potential antitumor agents." @default.
- W4293219195 created "2022-08-27" @default.
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- W4293219195 date "2022-08-24" @default.
- W4293219195 modified "2023-09-26" @default.
- W4293219195 title "Reduced Graphene Oxide Modulates the FAK-Dependent Signaling Pathway in Glioblastoma Multiforme Cells In Vitro" @default.
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- W4293219195 doi "https://doi.org/10.3390/ma15175843" @default.
- W4293219195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36079225" @default.
- W4293219195 hasPublicationYear "2022" @default.
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