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- W4293221147 endingPage "784" @default.
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- W4293221147 abstract "In the case of many bacteria, such as Escherichia coli, the composition of lipid molecules, termed the lipidome, temporally adapts to different environmental conditions and thus modifies membrane properties to permit growth and survival. Details of the relationship between the environment and lipidome composition are lacking, particularly for growing cultures under either favourable or under stress conditions. Here, we highlight compositional lipidome changes by describing the dynamics of molecular species throughout culture-growth phases. We show a steady cyclopropanation of fatty acyl chains, which acts as a driver for lipid diversity. There is a bias for the cyclopropanation of shorter fatty acyl chains (FA 16:1) over longer ones (FA 18:1), which likely reflects a thermodynamic phenomenon. Additionally, we observe a nearly two-fold increase in saturated fatty acyl chains in response to the presence of ampicillin and chloramphenicol, with consequences for membrane fluidity and elasticity, and ultimately bacterial stress tolerance. Our study provides the detailed quantitative lipidome composition of three E. coli strains across culture-growth phases and at the level of the fatty acyl chains and provides a general reference for phospholipid composition changes in response to perturbations. Thus, lipidome diversity is largely transient and the consequence of lipid synthesis and cyclopropanation." @default.
- W4293221147 created "2022-08-27" @default.
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- W4293221147 date "2022-08-24" @default.
- W4293221147 modified "2023-10-05" @default.
- W4293221147 title "Transient Complexity of E. coli Lipidome Is Explained by Fatty Acyl Synthesis and Cyclopropanation" @default.
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- W4293221147 doi "https://doi.org/10.3390/metabo12090784" @default.
- W4293221147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36144187" @default.
- W4293221147 hasPublicationYear "2022" @default.
- W4293221147 type Work @default.