Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293230442> ?p ?o ?g. }
- W4293230442 abstract "Though the facilitating influence of stress on drug abuse is well documented, the mechanisms underlying this interaction have yet to be fully elucidated. The present study explores the neurobiological mechanisms underpinning the sensitized response to the psychomotor-stimulating effects of cocaine following chronic restraint stress (CRS), emphasizing the differential contribution of both subcompartments of the nucleus accumbens (NA), the core (NAcore) and shell (NAshell), to this phenomenon. Adult male Wistar rats were restrained for 2 h/day for 7 days and, 2 weeks after the last stress exposure (day 21), all animals were randomly assigned to behavioral, biochemical or neurochemical tests. Our results demonstrated that the enduring CRS-induced increase in psychostimulant response to cocaine was paralleled by an increase of extracellular dopamine levels in the NAcore, but not the NAshell, greater than that observed in the non-stress group. Furthermore, we found that CRS induced an impairment of glutamate homeostasis in the NAcore, but not the NAshell. Its hallmarks were increased basal extracellular glutamate concentrations driven by a CRS-induced downregulation of GLT-1, blunted glutamate levels in response to cocaine and postsynaptic structural remodeling in pre-stressed animals. In addition, ceftriaxone, a known GLT-1 enhancer, prevented the CRS-induced GLT-1 downregulation, increased basal extracellular glutamate concentrations and changes in structural plasticity in the NAcore as well as behavioral cross-sensitization to cocaine, emphasizing the biological importance of GLT-1 in the comorbidity between chronic stress exposure and drug abuse. A future perspective concerning the paramount relevance of the stress-induced disruption of glutamate homeostasis as a vulnerability factor to the development of stress and substance use disorders during early life or adulthood of descendants is provided." @default.
- W4293230442 created "2022-08-27" @default.
- W4293230442 creator A5006184933 @default.
- W4293230442 creator A5033182066 @default.
- W4293230442 creator A5046043329 @default.
- W4293230442 creator A5054608100 @default.
- W4293230442 creator A5055964153 @default.
- W4293230442 creator A5057034325 @default.
- W4293230442 creator A5063772450 @default.
- W4293230442 creator A5071019943 @default.
- W4293230442 creator A5074865815 @default.
- W4293230442 creator A5090191962 @default.
- W4293230442 date "2022-08-26" @default.
- W4293230442 modified "2023-10-06" @default.
- W4293230442 title "Impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress" @default.
- W4293230442 cites W1484549127 @default.
- W4293230442 cites W1511830919 @default.
- W4293230442 cites W1550555866 @default.
- W4293230442 cites W1567339226 @default.
- W4293230442 cites W1592375995 @default.
- W4293230442 cites W1632957190 @default.
- W4293230442 cites W1674080254 @default.
- W4293230442 cites W1727198338 @default.
- W4293230442 cites W1798313689 @default.
- W4293230442 cites W1820117428 @default.
- W4293230442 cites W1822992619 @default.
- W4293230442 cites W1825179960 @default.
- W4293230442 cites W1893085660 @default.
- W4293230442 cites W1902584234 @default.
- W4293230442 cites W1949928978 @default.
- W4293230442 cites W1956962234 @default.
- W4293230442 cites W1963790626 @default.
- W4293230442 cites W1968806338 @default.
- W4293230442 cites W1970874792 @default.
- W4293230442 cites W1972949334 @default.
- W4293230442 cites W1976097422 @default.
- W4293230442 cites W1977850361 @default.
- W4293230442 cites W1980574091 @default.
- W4293230442 cites W1981670902 @default.
- W4293230442 cites W1983553517 @default.
- W4293230442 cites W1987449042 @default.
- W4293230442 cites W1990500215 @default.
- W4293230442 cites W1997348318 @default.
- W4293230442 cites W1999830007 @default.
- W4293230442 cites W2000105160 @default.
- W4293230442 cites W2000825098 @default.
- W4293230442 cites W2001528712 @default.
- W4293230442 cites W2004000125 @default.
- W4293230442 cites W2007583443 @default.
- W4293230442 cites W2012746213 @default.
- W4293230442 cites W2012985830 @default.
- W4293230442 cites W2013956365 @default.
- W4293230442 cites W2018910959 @default.
- W4293230442 cites W2021594631 @default.
- W4293230442 cites W2022859201 @default.
- W4293230442 cites W2027940350 @default.
- W4293230442 cites W2027995181 @default.
- W4293230442 cites W2030957166 @default.
- W4293230442 cites W2036405095 @default.
- W4293230442 cites W2039071007 @default.
- W4293230442 cites W2043713804 @default.
- W4293230442 cites W2045127445 @default.
- W4293230442 cites W2045185962 @default.
- W4293230442 cites W2047950534 @default.
- W4293230442 cites W2048419985 @default.
- W4293230442 cites W2058073897 @default.
- W4293230442 cites W2059980385 @default.
- W4293230442 cites W2060236812 @default.
- W4293230442 cites W2061673365 @default.
- W4293230442 cites W2061811160 @default.
- W4293230442 cites W2066147083 @default.
- W4293230442 cites W2074070434 @default.
- W4293230442 cites W2075370186 @default.
- W4293230442 cites W2079326043 @default.
- W4293230442 cites W2084967673 @default.
- W4293230442 cites W2085091544 @default.
- W4293230442 cites W2090517702 @default.
- W4293230442 cites W2093716510 @default.
- W4293230442 cites W2095780210 @default.
- W4293230442 cites W2099347739 @default.
- W4293230442 cites W2110325210 @default.
- W4293230442 cites W2111938034 @default.
- W4293230442 cites W2114229060 @default.
- W4293230442 cites W2116342741 @default.
- W4293230442 cites W2120279490 @default.
- W4293230442 cites W2124427999 @default.
- W4293230442 cites W2160080372 @default.
- W4293230442 cites W2170250876 @default.
- W4293230442 cites W2175847813 @default.
- W4293230442 cites W2211535413 @default.
- W4293230442 cites W2231709936 @default.
- W4293230442 cites W2248682259 @default.
- W4293230442 cites W2280243664 @default.
- W4293230442 cites W2460802970 @default.
- W4293230442 cites W2501807363 @default.
- W4293230442 cites W2560568756 @default.
- W4293230442 cites W2590582580 @default.
- W4293230442 cites W2741605336 @default.
- W4293230442 cites W2808339677 @default.
- W4293230442 cites W2974116126 @default.