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- W4293231181 abstract "Introduction: Previous studies also showed a higher IUI success rate after slow-release insemination instead of bolus injection. Aim of the study: To examine whether a modified slow-release insemination (SRI) increases the clinical pregnancy rate (CPR) after intrauterine insemination with partner semen (IUI-P) and donor semen (IUI-D) Methods: We studied the data of an ongoing prospective cohort study. During the period of July 2011 until December 2018, data from 2565 IUI-Ps in 989 women and 1995 IUI-Ds in 606 women were collected prospectively. As from January 2016 (period 2), the insemination procedure was performed by midwives instead of medical doctors. Instead of bolus injection of sperm a slow-release IUI was performed. Instead of ordinary logistic regression analysis we used a cluster-weighted generalized estimating equations (GEEs) for statistical analysis. Results of two periods (2011-2015 and 2016-2018) were examined for both homologous and donor inseminations. Results: Clinical pregnancy rates (presence of fetal heart beat at 7-8 weeks of gestation) ollowing IUI-P increased significantly from 9.0 % (period 1) to 13.4 % (period 2) (p = 0.001). In case of donor inseminations, clinical pregnancy rates increased from 16.5 % to 20.8 % (p = 0.088), a non-significant increase. Conclusion: The CPR after modified slow-release inseminations increased significantly after IUI with homologous semen. After using donor sperm the CPR increased from 16.6 % to 20.8 % per cycle with donor semen, a non-significant increase. Although our results were analysed in a prospective cohort study, a prospective randomised trial is needed to confirm our findings. We also have to examine whether our better results can be explained by the slow-release IUI, the patient-centred approach or both." @default.
- W4293231181 created "2022-08-27" @default.
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- W4293231181 date "2022-03-01" @default.
- W4293231181 modified "2023-09-30" @default.
- W4293231181 title "371 Improving iui success after modified slow-release insemination: a prospective cohort study" @default.
- W4293231181 doi "https://doi.org/10.1016/j.ejogrb.2021.11.161" @default.
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