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- W4293234387 abstract "The skin irritation and sensitization potential of the new transdermal patch of the Thiocolchicoside formulated with Dura 87-6908 was evaluated on the rabbits and guinea pig as per the standard guidelines of OECD. Skin irritation test was performed on the rabbits by applying the placebo patch for 72 hours and dermal reactions like edema, erythema were noted. No clinical signs or dermal reactions were observed in the rabbits. Sensitization potential was measure on the guinea pig and animal was challenged to transdermal therapeutic system of the Thiocolchicoside, negative control group while group exposed to CDNB produced the sensitization reactions. These findings proved that Thiocolchicoside does not produce any dermal toxicity, irritation and sensitization and hence it is safe for dermal use." @default.
- W4293234387 created "2022-08-27" @default.
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- W4293234387 date "2022-04-18" @default.
- W4293234387 modified "2023-10-16" @default.
- W4293234387 title "Evaluation of the dermal irritation and skin sensitization due to thiocolchicoside transdermal drug delivery system" @default.
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- W4293234387 doi "https://doi.org/10.53730/ijhs.v6ns3.6274" @default.
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